Skip to main content

Research Repository

Advanced Search

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

Barlow, Peter G.; Svoboda, Pavel; Mackellar, Annie; Nash, Anthony A.; York, Ian A.; Pohl, Jan; Davidson, Donald J.; Donis, Ruben O.

Authors

Pavel Svoboda

Annie Mackellar

Anthony A. Nash

Ian A. York

Jan Pohl

Donald J. Davidson

Ruben O. Donis



Abstract

The extensive world-wide morbidity and mortality caused by influenza A viruses highlights the need for new insights into the host immune response and novel treatment approaches. Cationic Host Defense Peptides (CHDP, also known as antimicrobial peptides), which include cathelicidins and defensins, are key components of the innate immune system that are upregulated during infection and inflammation. Cathelicidins have immunomodulatory and anti-viral effects, but their impact on influenza virus infection has not been previously assessed. We therefore evaluated the effect of cathelicidin peptides on disease caused by influenza A virus in mice. The human cathelicidin, LL-37, and the murine cathelicidin, mCRAMP, demonstrated significant anti-viral activity in vivo, reducing disease severity and viral replication in infected mice to a similar extent as the well-characterized influenza virus-specific antiviral drug zanamivir. In vitro and in vivo experiments suggested that the peptides may act directly on the influenza virion rather than via receptor-based mechanisms. Influenza virus-infected mice treated with LL-37 had lower concentrations of pro-inflammatory cytokines in the lung than did infected animals that had not been treated with cathelicidin peptides. These data suggest that treatment of influenza-infected individuals with cathelicidin-derived therapeutics, or modulation of endogenous cathelicidin production may provide significant protection against disease.

Journal Article Type Article
Acceptance Date Sep 1, 2011
Online Publication Date Oct 21, 2011
Publication Date Oct 21, 2011
Deposit Date Mar 27, 2012
Publicly Available Date Mar 27, 2012
Journal PLoS One
Print ISSN 1932-6203
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 6
Issue 10
Article Number e25333
DOI https://doi.org/10.1371/journal.pone.0025333
Keywords General Biochemistry, Genetics and Molecular Biology; General Agricultural and Biological Sciences; General Medicine
Public URL http://researchrepository.napier.ac.uk/id/eprint/5170
Publisher URL http://dx.doi.org/10.1371/journal.pone.0025333
Contract Date Mar 27, 2012

Files

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37 (463 Kb)
PDF

Publisher Licence URL
https://creativecommons.org/licenses/publicdomain

Copyright Statement
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.





You might also like



Downloadable Citations