Skip to main content

Research Repository

Advanced Search

Antiviral potential of cathelicidins

Barlow, Peter G; Findlay, Emily Gwyer; Currie, Silke M; Davidson, Donald J

Authors

Emily Gwyer Findlay

Silke M Currie

Donald J Davidson



Abstract

The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host defenses against viral infections has started to offer potential for novel therapeutic strategies. An area of current research interest is in understanding the roles played by naturally occurring cationic host defense peptides, such as the cathelicidins, in these innate antiviral host defenses across different species. This research also has the potential to inform the design of novel synthetic antiviral peptide analogs and/or provide rationale for therapies aimed at boosting the natural production of these peptides. In this review, we will discuss our knowledge of the antiviral activities of cathelicidins, an important family of cationic host defense peptides, and consider the implications for novel antiviral therapeutic approaches.

Journal Article Type Review
Acceptance Date Dec 13, 2013
Online Publication Date Dec 13, 2013
Publication Date 2014-01
Deposit Date Jul 14, 2014
Journal Future Microbiology
Print ISSN 1746-0913
Electronic ISSN 1746-0921
Publisher Future Medicine
Peer Reviewed Peer Reviewed
Volume 9
Issue 1
Pages 55-73
DOI https://doi.org/10.2217/fmb.13.135
Keywords Adenovirus; antimicrobial peptide; cationic host defense peptide; herpes simplex virus; HIV; Influenza; innateimmunity; respiratory syncytial virus; vaccinia virus; virus
Public URL http://researchrepository.napier.ac.uk/id/eprint/6911
Publisher URL http://dx.doi.org/10.2217/fmb.13.135