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NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy

Fox, Sarah; Wilkinson, Tom S.; Wheatley, Paul S.; Xiao, Bo; Morris, Russell E.; Sutherland, Alistair; Simpson, A. John; Barlow, Peter G.; Butler, Anthony R.; Megson, Ian L.; Rossi, Adriano G

Authors

Sarah Fox

Tom S. Wilkinson

Paul S. Wheatley

Bo Xiao

Russell E. Morris

Alistair Sutherland

A. John Simpson

Anthony R. Butler

Ian L. Megson

Adriano G Rossi



Abstract

Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchangedzeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchangedzeolitematerial at a 50 wt.% composition in a polytetrafluoroethylene polymer. Further to our published data showing the anti-thrombotic effects of a similar NO-loadedzeolite, this study demonstrates the anti-bacterial properties of NO-releasing zeolites against clinically relevant strains of bacteria, namely Gram-negative Pseudomonas aeruginosa and Gram-positive methicillin-sensitive and methicillin-resistant Staphylococcus aureus and Clostridium difficile. Thus our study highlights the potential of NO-loadedzeolites as biocompatible medical device coatings with anti-infective properties

Journal Article Type Article
Publication Date 2010-04
Deposit Date Mar 27, 2012
Print ISSN 1742-7061
Electronic ISSN 1878-7568
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 6
Issue 4
Pages 1515-1521
DOI https://doi.org/10.1016/j.actbio.2009.10.038
Keywords Nitric oxide; Zeolite; Anti-bacterial; Biocompatibility; Infection
Public URL http://researchrepository.napier.ac.uk/id/eprint/5172
Publisher URL http://dx.doi.org/10.1016/j.actbio.2009.10.038