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Outputs (12)

Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling (2024)
Preprint / Working Paper
Elsharkasi, M., Villani, B., Wells, G., & Kerr, F. Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling

As a gate-keeper of anti-oxidant, anti-inflammatory and xenobiotic cell protection mechanisms, the transcription factor Nrf2 has been implicated as a promising therapeutic target for several neurodegenerative diseases, leading to the development of N... Read More about Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling.

β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting (2024)
Journal Article
Baghestani, S., Haldin, C., Kosijer, P., Alam, C. M., & Toivola, D. M. (2024). β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting. American Journal of Physiology - Cell Physiology, 327(2), C462-C476. https://doi.org/10.1152/ajpcell.00123.2024

Islet β-cell dysfunction is an underlying factor for type I diabetes (T1D) development. Insulin sensing and secretion are tightly regulated in β-cells at multiple subcellular levels. The epithelial intermediate filament (IF) protein keratin (K) 8 is... Read More about β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting.

Beyond the Advanced Therapies Skills Training Network: An Instrumental Case Study of Life Sciences Skills Development for Biomedical Science Graduates in Scotland (2023)
Journal Article
Garden, C. L. P. (2023). Beyond the Advanced Therapies Skills Training Network: An Instrumental Case Study of Life Sciences Skills Development for Biomedical Science Graduates in Scotland. British Journal of Biomedical Science, 80, Article 11654. https://doi.org/10.3389/bjbs.2023.11654

Biomedical sciences graduates are employed in a variety of different settings and form a significant part of the Life Sciences sector workforce in Scotland. Their degrees should equip them with the skills and knowledge to not only enter the workplace... Read More about Beyond the Advanced Therapies Skills Training Network: An Instrumental Case Study of Life Sciences Skills Development for Biomedical Science Graduates in Scotland.

Antimicrobial resistance of Neisseria Gonorrhoeae in Lesotho (2023)
Presentation / Conference Contribution
Maduna, L. D., Taole, M., Mothobi, I., Makuebu, M., Mosehle, T., Nyangu, I., Motanteli, K., & Peters, R. (2023, July). Antimicrobial resistance of Neisseria Gonorrhoeae in Lesotho. Poster presented at Asia-Pacific Congress of Clinical Microbiology and Infection (APCCMI), Seoul, Korea

Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq (2023)
Journal Article
Stokes, T., Cen, H. H., Kapranov, P., Gallagher, I. J., Pitsillides, A. A., Volmar, C., Kraus, W. E., Johnson, J. D., Phillips, S. M., Wahlestedt, C., & Timmons, J. A. (2023). Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq. Advanced Genetics, 4(2), Article 2200024. https://doi.org/10.1002/ggn2.202200024

Sequencing the human genome empowers translational medicine, facilitating transcriptome-wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short-read RNA sequenc... Read More about Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq.

Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer (2022)
Presentation / Conference Contribution
Bruce, I., Pang, L., Poole, A., & Fraser, J. (2022, November). Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer. Poster presented at Society for Endocrinology BES 2022, Harrogate

Neuroendocrine castrate resistant prostate cancer (NE-CRPC) is a lethal CRPC subtype that arises as prostate cancer cells transdifferentiate to neuroendocrine cells, evading the potent selective pressure of androgen deprivation therapies (ADT). Curre... Read More about Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer.

Using immersive tech to enrich healthcare education (2022)
Digital Artefact
McKenzie, C., Skinner, J., & Poole, A. Using immersive tech to enrich healthcare education. [Article]

As virtual reality technology has become more affordable and user friendly, it opens opportunities to enhance teaching of clinical skills. Here’s how one team brings VR into the classroom

“MedChemVR”: a virtual reality game to enhance medicinal chemistry education (2021)
Journal Article
Abuhammad, A., Falah, J., Alfalah, S. F. M., Abu-Tarboush, M., Tarawneh, R. T., Drikakis, D., & Charissis, V. (2021). “MedChemVR”: a virtual reality game to enhance medicinal chemistry education. Multimodal Technologies and Interaction, 5(3), Article 10. https://doi.org/10.3390/mti5030010

Medicinal chemistry (MC) is an indispensable component of the pharmacy curriculum. The pharmacists’ unique knowledge of a medicine’s chemistry enhances their understanding of the pharmacological activity, manufacturing, storage, use, supply, and hand... Read More about “MedChemVR”: a virtual reality game to enhance medicinal chemistry education.

Machine-Learning Methods for Computational Science and Engineering (2020)
Journal Article
Frank, M., Drikakis, D., & Charissis, V. (2020). Machine-Learning Methods for Computational Science and Engineering. Computation, 8(1), Article 15. https://doi.org/10.3390/computation8010015

The re-kindled fascination in machine learning (ML), observed over the last few decades, has also percolated into natural sciences and engineering. ML algorithms are now used in scientific computing, as well as in data-mining and processing. In this... Read More about Machine-Learning Methods for Computational Science and Engineering.

The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males (2019)
Presentation / Conference Contribution
Leggate, M., Florida-James, G., Ross, M., Jurevicius, M., Duncan, G., & Lithgow, H. (2019, December). The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males. Presented at Future Physiology, Liverpool, UK

A low vitamin D status has been identified as an association risk factor in the etiology of numerous chronic diseases, with older adults identified as generally more deficient than younger populations. Exercise has been shown to act as a direct and i... Read More about The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males.