An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD Sep 1, 2014 - Aug 31, 2017
Recent genetic discoveries, principally identification of NOD2 and ATG16L1 as susceptibility loci, strongly implicate a dysregulated host response to enteric bacteria and the autophagy pathway in the pathogenesis of Crohn’s disease (CD). Several micr... Read More about An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD.

Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection May 1, 2015 - Jun 30, 2017
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a potential host defence mechanism. We propose to c... Read More about Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection.

PCOS and Thyroid dysfunction Jun 1, 2015 - Aug 1, 2015
Undergraduate vacation scholarship application to study the legacy of prenatal programming of polycystic ovary syndrome on postnatal throid function

Sex-specific disease aetiology from developmental steroid insults: mechanistic understanding and biomarker development towards disease prevention Jun 1, 2017 - Oct 1, 2021
Risks of developing many adult illnesses are set down as we develop in the womb, hence the environment we experience during fetal life needs to be ‘just right’. Understanding how the fetal environment colours development helps decision making during... Read More about Sex-specific disease aetiology from developmental steroid insults: mechanistic understanding and biomarker development towards disease prevention.

Polycystic ovary syndrome (PCOS) developmental model May 1, 2010 - Jun 5, 2014
Polycystic ovary syndrome (PCOS) is common: more than one in 1 in 15 young women has this condition. There are many associated health problems including abnormal periods, miscarriages, infertility, excess hair, acne, weight gain, diabetes and heart d... Read More about Polycystic ovary syndrome (PCOS) developmental model.

The Antiviral activities of the cationic host defence peptide LL-37 against Rhinovirus Feb 1, 2013 - Nov 12, 2014
A pump-priming proposal designed to investigate the potential for LL-37, a human cationic host defence peptide, to inhibit Rhinovirus infection and/or target cells infected with Rhinovirus for induction of apoptotic cell death

Acceptability of extragenital Chlamydia testing Sep 1, 2017 - Apr 30, 2018
Chlamydia trachomatis is the most common sexually transmitted infection in Scotland, and has significant long‐term consequences to reproductive health. Recent studies suggest that in addition to the genital tract, Chlamydia is found in the throat and... Read More about Acceptability of extragenital Chlamydia testing.

Does the gut microbiome play a role in polycystic ovary syndrome? Feb 1, 2017 - Oct 31, 2018
Does the gut microbiome play a role in polycystic ovary syndrome?

Biochemical Society Summer Vacation Scholarship May 15, 2017 - Jul 10, 2017
Nrf2, a transcriptional activator of cell protection genes, is an emerging target for neurodegenerative conditions including Alzheimer’s disease (AD). Nrf2 activity is reduced in dementia patients and Nrf2 inducing compounds prevent neuronal damage i... Read More about Biochemical Society Summer Vacation Scholarship.

Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis Sep 1, 2018 - Apr 30, 2023
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately produces pain and the impairment of normal activities... Read More about Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis.

IBD drug effect on autophagy (IDEA) Oct 1, 2017 - Mar 31, 2018
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD

Bacteriophage endolysins and novel lipid-degrading proteins as a treatment for Rhodococcus equi infections in foals Oct 1, 2018 - Dec 31, 2019
Rhodococcus equi (Req) is responsible for severe respiratory disease of foals with a major economic impact on the equine industry, and can be endemic on stud farms. In foals under 6 months of age, this bacterial disease manifests as pneumonia, with 3... Read More about Bacteriophage endolysins and novel lipid-degrading proteins as a treatment for Rhodococcus equi infections in foals.

Mechanism of Chlamydia induced progesterone resistance Apr 1, 2018 - Jul 31, 2019
Chlamydia trachomatis is the most common sexually-transmitted infection in the world, and is associated with miscarriage, pre-term birth and infertility. However, the understanding of the mechanisms through which infection leads to pregnancy failure... Read More about Mechanism of Chlamydia induced progesterone resistance.

Development of a UV-C hand-sanitiser unit Nov 1, 2017 - Dec 22, 2017
Development of a UV-C hand-sanitiser unit

Rutherford fund Strategic Partner Grant Sep 1, 2018 - Mar 31, 2019
Rutherford Fellows, will work in project areas related to food safety (Pathogen detection, AMR etc) and food spoilage.

Rutherford Fund, are funded by BEIS and the scheme is being managed by Universities UK International

Ranking novel immune-modulating therapeutics for progression to clinical development Jul 2, 2018 - Sep 30, 2019
Ranking novel immune-modulating therapeutics for progression to clinical development

TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector. Apr 1, 2018 - Oct 21, 2019
TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.

Investigating new therapies for osteoarthritis: a collaboration between ENU and Guangzhou Medical University, China May 1, 2018 - Aug 31, 2022
Investigating new therapies for osteoarthritis: a collaboration between ENU and Guangzhou Medical University, China

Osteoarthritis is the most important ageing-related disease, estimated to affect 13% of the UK population, and 8% of the Chinese po... Read More about Investigating new therapies for osteoarthritis: a collaboration between ENU and Guangzhou Medical University, China.

Direct and paracrine effects of Chlamydia infection on decidualisation of endometrial stromal cells Jun 1, 2018 - Aug 31, 2018
SRF summer studentship

Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection Apr 1, 2019 - Mar 31, 2022
A significant challenge faced by modern society is the lack of therapeutics for a large number of infections, particularly those that are endemic or widely spread in developing countries. Dengue is one such infection which is endemic inIndonesia - it... Read More about Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection.