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Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions (2024)
Journal Article
Neri, I., MacCallum, J., Di Lorenzo, R., Russo, G., Lynen, F., & Grumetto, L. (2024). Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions. Science of the Total Envir

Five parabens (PBs) i.e., Methylparaben (MP), Ethylparaben (EP), Isopropylparaben (iPrP), Isobutylparaben (iBuP), Benzylparaben (BzP), and their parent compound i.e., para–hydroxy Benzoic Acid (pHBA), were studied both in vitro and in silico. Specifi... Read More about Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions.

High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC (2023)
Journal Article
Russo, G., Kajtazi, A., Vallaro, M., Surmont, P., Ermondi, G., Anderson, S., Grumetto, L., Caron, G., & Lynen, F. (2023). High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode

The charge state of a molecule is the single most prominent attribute ruling out its interactions with the surrounding environment. In a previous study, the retention of acids on the new Celeris™ Arginine (ARG) column was found to b... Read More about High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC.

Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction (2023)
Journal Article
Kajtazi, A., Russo, G., Wicht, K., Eghbali, H., & Lynen, F. (2023). Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction. Chemosphere, 337, Article 139361. https://doi.org/10.1016/j.chemosphere.2023

Implementing effective environmental management strategies requires a comprehensive understanding of the chemical composition of environmental pollutants, particularly in complex mixtures. Utilizing innovative analytical techniques, such as high-reso... Read More about Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction.

Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors (2022)
Journal Article
Russo, G., Piccolo, M., Neri, I., Ferraro, M. G., Santamaria, R., & Grumetto, L. (2023). Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors. Chemosphere, 313, Article 137569. https://doi.org/10.1016/j.chemosp

Endocrine disruptors are chemicals widely used worldwide by industries in a variety of applications. Routinely exposure to these chemicals, even if at low doses, can cause damage effects on human health. In the present study, we evaluated toxic effec... Read More about Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors.

Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients (2022)
Journal Article
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., …Vitale, M. (2023). Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients. Environmental Pollution, 316, Article 120478. https://doi.org/1

Bisphenol A (BPA) is a widespread thyroid disruptor, but evidence about an association with thyroid cancer is weak. Excess body weight is a risk factor for thyroid cancer and affects activity of endocrine disruptors. Aim of the study was to investiga... Read More about Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients.

Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers (2022)
Journal Article
Di Lorenzo, R., Neri, I., Russo, G., Laneri, S., & Grumetto, L. (2022). Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers. Cosmetics, 9(5), Article 102. https://doi.org/10.3390/cosmetics9050102

A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also... Read More about Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers.

Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography (2022)
Journal Article
Neri, I., Laneri, S., Di Lorenzo, R., Dini, I., Russo, G., & Grumetto, L. (2022). Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography. Molecules, 27(13), Article 4263

Parabens (PBs) are used as preservatives to extend the shelf life of various foodstuffs, and pharmaceutical and cosmetic preparations. In this work, the membrane barrier passage potential of a subset of seven parabens, i.e., methyl-, ethyl-, propyl-... Read More about Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography.

Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy (2022)
Journal Article
Russo, G., Laneri, S., Di Lorenzo, R., Neri, I., Dini, I., Ciampaglia, R., & Grumetto, L. (2022). Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy. Molecules, 27(13), Article 3990. https://doi.org/10.3390/molecules27133990

The concentration levels of thirteen organic pollutants and selected heavy metals were investigated in 40 plastics bottled and tap water samples. Some of the selected contaminants have an ascertained or suspected endocrine disrupting activity, such a... Read More about Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy.

cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity? (2021)
Journal Article
Grumetto, L., & Russo, G. (2021). cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?. ADMET and DMPK, 9(4), 267-281. https://doi.org/10.5599/admet.1034

56 compounds, whose log BB values were known from the scientific literature, were considered and their phospholipophilicity values were calculated in silico. These values, along with either experimentally determined or calculated lipophilicity values... Read More about cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?.

Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis (2021)
Journal Article
Russo, G., Vallaro, M., Cappelli, L., Anderson, S., Ermondi, G., & Caron, G. (2021). Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis. Journal of Chroma

CelerisTM Arginine (ARG) is a mixed-mode stationary phase recently released on the market. To characterize its analytical behavior, the retention factors of a pool (n=100, of which 36 neutrals, 26 acids and 38 bases) of pharmaceutically relevant comp... Read More about Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis.

Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells (2021)
Journal Article
Russo, G., Iaccarino, G., Piccolo, M., Ferraro, M. G., Vecchione, R., Grumetto, L., …Santamaria, R. (2021). Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer

A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form and termed rMnSOD. As compared to other SODs, this isoform exhibits a dramatically improved cellular uptake and an int... Read More about Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells.

The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy (2021)
Journal Article
Russo, G., Laneri, S., Di Lorenzo, R., Ferrara, L., & Grumetto, L. (2021). The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy. Water Environment Research, 93(10), 1944-1958. https://do

Endocrine disrupting chemicals (EDCs) are agents able to exert perturbation toward the endocrine system via a broad array of signalling pathways. Some EDCs are released into the environment as a result of antropogenic activities. Analytical surveilla... Read More about The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy.

Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment (2021)
Journal Article
Akhbarizadeh, R., Russo, G., Rossi, S., Golianova, K., Moore, F., Guida, M., De Falco, M., & Grumetto, L. (2021). Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment. Marin

The occurrence of endocrine disrupting chemicals (EDCs) has been determined in two widely consumed fish species from Persian Gulf i.e., Epinephelus coioides and Platycephalus indicus by applying a validated analytical for the simultaneous detection o... Read More about Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment.

Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development (2020)
Journal Article
Russo, G., Grumetto, L., Baert, M., & Lynen, F. (2021). Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development. Analytica Chimica Acta, 1142, 157

A comprehensive two-dimensional liquid chromatography-based biomimetic platform (LCxLC) has been developed and validated for drug diffusion studies. Human serum albumin (HSA) and immobilized artificial membrane (IAM) were thereby used in the first (1... Read More about Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development.

Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity (2020)
Journal Article
Russo, G., Ermondi, G., Caron, G., Verzele, D., & Lynen, F. (2021). Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity. European Journal of Pharmaceutical

State of the art: Sphingomyelin (SPH) is a type of sphingolipid found in animal nerve tissues, especially in the membranous myelin sheath that surrounds some nerve cell axons. Because of its characteristics, SPH stationary phase represents an ideal t... Read More about Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity.

Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution (2019)
Journal Article
Russo, G., Grumetto, L., Mita, D. G., Rossi, S., Guida, M., Di Marco Pisciottano, I., & Gallo, P. (2019). Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and cata

The removal of 17alfa-ethinylestradiol (EE2) from synthetic aqueous solutions under adsorption process and enzyme catalysis mediated by immobilized laccase from Trametes versicolor was studied. Both processes were carried... Read More about Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution.

Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection (2019)
Journal Article
Del Prete, S., Marasco, D., Del Prete, A., Meloni, M., Capaldi, R., Grumetto, L., & Russo, G. (2019). Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection. Archives of Case Reports, 3(1),

Purpose: This work is aimed at demonstrating that scraping cytology and scanning electron microscopy can successfully assist in the diagnosis of nontuberculous mycobacteria infection. For this purpose, we report the use of both these techniques in th... Read More about Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection.

Are Canned Beverages Industries Progressively Switching to Bisphenol AF? (2019)
Journal Article
Russo, G., Varriale, F., Barbato, F., & Grumetto, L. (2019). Are Canned Beverages Industries Progressively Switching to Bisphenol AF?. Journal of Food Science, 84(11), 3303-3311. https://doi.org/10.1111/1750-3841.14833

Seven bisphenols, endocrine‐disruptor chemicals, were analytically determined for risk assessment in 52 large‐consumption beverages collected from the Italian market. The analytes under examination were bisphenol A, bisphenol F, bisphenol E, bispheno... Read More about Are Canned Beverages Industries Progressively Switching to Bisphenol AF?.

Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe (2019)
Journal Article
Russo, G., Barbato, F., Mita, D. G., & Grumetto, L. (2019). Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe. Food and Chemical Toxicology, 131, https://doi.org/10.1016/j.fct.2019.110575

Bisphenol A and its analogues belong to the class of endocrine disrupting chemicals, massively employed by industries to produce polycarbonate and epoxy resins, designed to be in direct contact with foodstuffs. Their leaching from the canned packagin... Read More about Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe.