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Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography

Neri, Ilaria; Laneri, Sonia; Di Lorenzo, Ritamaria; Dini, Irene; Russo, Giacomo; Grumetto, Lucia

Authors

Ilaria Neri

Sonia Laneri

Ritamaria Di Lorenzo

Irene Dini

Lucia Grumetto



Abstract

Parabens (PBs) are used as preservatives to extend the shelf life of various foodstuffs, and pharmaceutical and cosmetic preparations. In this work, the membrane barrier passage potential of a subset of seven parabens, i.e., methyl-, ethyl-, propyl- isopropyl, butyl, isobutyl, and benzyl paraben, along with their parent compound, p-hydroxy benzoic acid, were studied. Thus, the Franz cell diffusion (FDC) method, biomimetic liquid chromatography (BLC), and in silico prediction were performed to evaluate the soundness of both describing their permeation through the skin. While BLC allowed the achievement of a full scale of affinity for membrane phospholipids of the PBs under research, the permeation of parabens through Franz diffusion cells having a carbon chain > ethyl could not be measured in a fully aqueous medium, i.e., permeation enhancer-free conditions. Our results support that BLC and in silico prediction alone can occasionally be misleading in the permeability potential assessment of these preservatives, emphasizing the need for a multi-technique and integrated experimental approach.

Journal Article Type Article
Acceptance Date Jun 28, 2022
Online Publication Date Jul 1, 2022
Publication Date Jul 1, 2022
Deposit Date Jul 5, 2022
Publicly Available Date Jul 5, 2022
Journal Molecules
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 27
Issue 13
Article Number 4263
DOI https://doi.org/10.3390/molecules27134263
Keywords parabens; investigative toxicology; skin; Franz cell; lipophilicity; chromatography approach; immobilized artificial membrane
Public URL http://researchrepository.napier.ac.uk/Output/2884699

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