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Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers

Di Lorenzo, Ritamaria; Neri, Ilaria; Russo, Giacomo; Laneri, Sonia; Grumetto, Lucia

Authors

Ritamaria Di Lorenzo

Ilaria Neri

Sonia Laneri

Lucia Grumetto



Abstract

A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also detected in many personal care products and therefore can be absorbed by the skin. A solid/liquid extraction followed by a gradient elution chromatographic separation method was performed and validated according to European guidelines. Our validated method afforded the detection of all seven parabens with limit of detection values ranging from 0.026 to 0.090 μg mL−1 and recoveries ranging from 61.80 to 105.73 μg mL−1 at high and low concentration values (50.0–5.0 μg mL−1), respectively. The proposed method can help assess paraben’s skin bioaccumulation since people are repeatedly exposed to consumer goods containing parabens in their daily routine, posing a chronic risk to human health.

Citation

Di Lorenzo, R., Neri, I., Russo, G., Laneri, S., & Grumetto, L. (2022). Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers. Cosmetics, 9(5), Article 102. https://doi.org/10.3390/cosmetics9050102

Journal Article Type Article
Acceptance Date Oct 8, 2022
Online Publication Date Oct 10, 2022
Publication Date 2022
Deposit Date Oct 17, 2022
Publicly Available Date Oct 17, 2022
Journal Cosmetics
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 9
Issue 5
Article Number 102
DOI https://doi.org/10.3390/cosmetics9050102
Keywords parabens; chemical analysis; extraction method; skin barrier; penetration
Public URL http://researchrepository.napier.ac.uk/Output/2933053

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