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Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick (2005)
Journal Article
Bock, J., Thode, C., Hannemann, O., Braun, K., & Darlison, M. (2005). Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick. Neuroscience, 133(3), 625-633. https://doi.org/10.1016/j.neuroscience.2005.02.048

We have cloned a full-length complementary {DNA} from the chicken (Gallus gallus domesticus), which encodes a polypeptide that exhibits ∼75% identity to the product of the mammalian gene Arc (activity-regulated cytoskeleton-associated protein), also... Read More about Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick.

Consequences of the Evolution of the GABAA Receptor Gene Family (2005)
Journal Article
Darlison, M. G., Pahal, I., & Thode, C. (2005). Consequences of the Evolution of the GABAA Receptor Gene Family. Cellular and Molecular Neurobiology, 25(3-4), 607-624. https://doi.org/10.1007/s10571-005-4004-4

1. This paper reviews the evolution of the family of genes present in mammals and other vertebrates that encode $γ$-aminobutyric acid (GABA) type A (GABAA) receptors, which are the major inhibitory neurotransmitter receptors in the central nervous sy... Read More about Consequences of the Evolution of the GABAA Receptor Gene Family.

Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit (2005)
Journal Article
Jones, A. K. M., Marshall, A., Darlison, M., Blake, A., Buckingham, S., Darlison, M., & Sattelle, D. (2005). Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit. Invertebrate Neuroscience, 5(3-4), 147-155. https://doi.org/10.1007/s10158-005-0007-6

The cloning, sequencing and functional expression of Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor (nAChR) subunit is described. This subunit shows 80% identity with the Drosophila melanogaster Dβ1 and 92% identi... Read More about Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit.

Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain (1986)
Book Chapter
Squire, M. D., Moss, S. J., Lai, F. A., Darlison, M. G., Cockcroft, V. B., Barnard, E. A., Beeson, D. M. W., Hicks, A. A., Darlison, M. G., & Ross, S. J. (1986). Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain. In A. Maelicke (Ed.), Nicotinic Acetylcholine Receptor (389-415). Springer. https://doi.org/10.1007/978-3-642-71649-2_30

While it has been completely established that the AChR** as isolated from the electroplaques of electric fish is composed of four different polypeptides, such that its subunit structure is α2βγδ (as reviewed in detail elsewhere in this Volume), the e... Read More about Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain.

Nucleotide sequence encoding the iron-sulphur protein subunit of the succinate dehydrogenase ofEscherichia coli (1984)
Journal Article
Darlison, M. G., & Guest, J. R. (1984). Nucleotide sequence encoding the iron-sulphur protein subunit of the succinate dehydrogenase ofEscherichia coli. Biochemical Journal, 223(2), 507-517. https://doi.org/10.1042/bj2230507

The nucleotide sequence of a 961 base-pair segment of DNA containing the sdhB gene, which encodes the iron-sulphur protein subunit of the E. coli succinate dehydrogenase, has been determined. The sdhB structural gene comprises 711 base pairs (237 cod... Read More about Nucleotide sequence encoding the iron-sulphur protein subunit of the succinate dehydrogenase ofEscherichia coli.

Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes (1989)
Journal Article
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes. Molecular Brain Research, 5(4), 305-310. https://doi.org/10.1016/0169-328x%2889%2990065-x

The distribution of 3 {GABAA} receptor α-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the α2- and α3-transcripts are of low abundance in all regions except striatum, the α1-transcript is... Read More about Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes.

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease (1989)
Journal Article
Buckle, V. J., Fujita, N., Ryder-Cook, A. S., Derry, J. M., Barnard, P. J., Lebo, R. V., Schofield, P. R., Seeburg, P. H., Bateson, A. N., Darlison, M. G., & Barnard, E. A. (1989). Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron, 3(5), 647-654. https://doi.org/10.1016/0896-6273%2889%2990275-4

Hybridization of {GABAA} receptor probes to human chromosomes in situ and to {DNA} from sorted human chromosomes has localized the genes encoding a β subunit and three isoforms of the a subunit. The α2 and β genes are both located on chromosome 4 in... Read More about Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.

The molecular basis of muscular dystrophy in the mdx mouse: a point mutation (1989)
Journal Article
Sicinski, P., Geng, Y., Ryder-Cook, A., Barnard, E., Darlison, M., & Barnard, P. (1989). The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science, 244(4912), 1578-1580. https://doi.org/10.1126/science.2662404

The mdx mouse is an X-linked myopathic mutant, an animal model for human Duchenne muscular dystrophy. In both mouse and man the mutations lie within the dystrophin gene, but the phenotypic differences of the disease in the two species confer much int... Read More about The molecular basis of muscular dystrophy in the mdx mouse: a point mutation.

Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer (1989)
Journal Article
Wisden, W., McNaughton, L. A., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer. Neuroscience Letters, 106(1-2), 7-12. https://doi.org/10.1016/0304-3940%2889%2990193-6

Using in situ hybridization histochemistry, we have demonstrated that 3 α subunit mRNAs of the {GABAA} receptor are present in different cell populations of the bovine cerebellum. While the α1 mRNA is the most abundant and is present in granule cells... Read More about Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer.

Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28 (1991)
Journal Article
Herman, G. E., Faust, C. J., Darlison, M. G., & Barnard, E. A. (1991). Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28. Genomics, 9(4), 670-677. https://doi.org/10.1016/0888-7543%2891%2990360-q

The four loci Gabra3, DXPas8, CamL1, and Bpa, located near the murine X-linked visual pigment gene (Rsup), have been ordered using 248 backcross progeny from an interspecific mating of (B6CBA-Aw-JA-Bpa) and Mus spretus. One hundred twenty backcross p... Read More about Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28.

Distinct regional expression of nicotinic acetylcholine receptor genes in chick brain (1990)
Journal Article
Morris, B. J., Hicks, A. A., Wisden, W., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1990). Distinct regional expression of nicotinic acetylcholine receptor genes in chick brain. Molecular Brain Research, 7(4), 305-315. https://doi.org/10.1016/0169-328x%2890%2990081-n

Four genes (α2, α3, α4 and β2) have been reported as encoding subunits of the nicotinic acetylcholine receptor (nAChR) in chicken brain. The mRNAs transcribed from these genes have here been localised to particular regions using in situ hybridisation... Read More about Distinct regional expression of nicotinic acetylcholine receptor genes in chick brain.

Amino acid receptors from insect muscle: electrophysiological characterization in Xenopus oocytes following expression by injection of mRNA (1990)
Journal Article
Fraser, S., Djamgoz, M., Usherwood, P., O'Brien, J., Darlison, M., & Barnard, E. (1990). Amino acid receptors from insect muscle: electrophysiological characterization in Xenopus oocytes following expression by injection of mRNA. Molecular Brain Research, 8(4), 331-341. https://doi.org/10.1016/0169-328x%2890%2990047-h

Poly(A)+ messenger ribonucleic acid (mRNA) was extracted from leg muscles of the locust Schistocerca gregaria and injected into oocytes of Xenopus laevis. After 5–10 days incubation, receptors for l-glutamate, l-quisqualate, dl-ibotenate and γ-aminob... Read More about Amino acid receptors from insect muscle: electrophysiological characterization in Xenopus oocytes following expression by injection of mRNA.

The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA (1991)
Journal Article
Bateson, A. N., Harvey, R. J., Wisden, W., Glencorse, T. A., Hicks, A. A., Hunt, S. P., Barnard, E. A., & Darlison, M. G. (1991). The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA. Molecular Brain Research, 9(4), 333-339. https://doi.org/10.1016/0169-328x%2891%2990081-8

We report the sequence of a complementary {DNA} (cDNA) that encodes the chicken {GABAA} receptor α1 subunit, which is extremely homologous to mammalian α1 subunits. The distribution of α1 subunit transcripts is shown to correlate mainly, but not comp... Read More about The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA.

y-Aminobutyric AcidA Receptor Heterogeneity Is Increased by Alternative Splicing of a Novel ?-Subunit Gene Transcript (1991)
Journal Article
Bateson, A. N., Lasham, A., & Darlison, M. G. (1991). y-Aminobutyric AcidA Receptor Heterogeneity Is Increased by Alternative Splicing of a Novel ?-Subunit Gene Transcript. Journal of Neurochemistry, 56(4), 1437-1440. https://doi.org/10.1111/j.1471-4159.1991.tb11443.x

Abstract: DNA sequences encoding two variants of a novel γ-aminobutyric acidA (GABAA) receptor β subunit were isolated from an embryonic chicken whole-brain cDNA library and a chicken genomic library. The coding regions of these variants only differ... Read More about y-Aminobutyric AcidA Receptor Heterogeneity Is Increased by Alternative Splicing of a Novel ?-Subunit Gene Transcript.

Conserved Organization of ?-Aminobutyric AcidAReceptor Genes: Cloning and Analysis of the Chicken ?4-Subunit Gene (1991)
Journal Article
Lasham, A., Vreugdenhil, E., Bateson, A. N., Barnard, E. A., & Darlison, M. G. (1991). Conserved Organization of ?-Aminobutyric AcidAReceptor Genes: Cloning and Analysis of the Chicken ?4-Subunit Gene. Journal of Neurochemistry, 57(1), 352-355. https://doi.org/10.1111/j.1471-4159.1991.tb02135.x

Abstract: A series of genomic clones containing DNA that encodes the chicken γ-aminobutyric acidA (GABAA) receptor β4 subunit have been isolated. These have been restriction mapped and partially sequcnced to determine the structural organization and... Read More about Conserved Organization of ?-Aminobutyric AcidAReceptor Genes: Cloning and Analysis of the Chicken ?4-Subunit Gene.