Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28

Herman, Gail E.; Faust, Cynthia J.; Darlison, Mark G.; Barnard, Eric A.

Abstract

The four loci Gabra3, DXPas8, CamL1, and Bpa, located near the murine X-linked visual pigment gene (Rsup), have been ordered using 248 backcross progeny from an interspecific mating of (B6CBA-Aw-JA-Bpa) and Mus spretus. One hundred twenty backcross progeny have been analyzed at seven anchor loci spanning the X chromosome and form a regional mapping panel. An additional 128 progeny have been screened for recombination events between Cf-9 and Dmd. Eighteen recombinants between these loci have been detected in the 248 animals; all of the recombinants were screened at the other anchor loci to identify any double crossovers. Pedigree analysis using these recombinants strongly favors a gene order of (Cf-9)-Gabra3-(DXPas8, Bpa)-CamL1-(Rsvp, P3, Cf-8)-Dmd for the loci studied. Synteny with human Xq27–Xq28 is retained, although the relative order of some loci may differ between the two species.

Citation

Herman, G. E., Faust, C. J., Darlison, M. G., & Barnard, E. A. (1991). Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28. Genomics, 9(4), 670-677. https://doi.org/10.1016/0888-7543%2891%2990360-q

• Journal Article Type: Article
• Publication Date: 1991-04
• Deposit Date: Jul 27, 2016
• Journal: Genomics
• Print ISSN: 0888-7543
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 4
• Pages: 670-677
• DOI: https://doi.org/10.1016/0888-7543%2891%2990360-q
• Keywords: Genetics,
• Public URL: http://researchrepository.napier.ac.uk/Output/317632
• Publisher URL: http://www.sciencedirect.com/science/article/pii/088875439190360Q