The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA

Bateson, Alan N.; Harvey, Robert J.; Wisden, William; Glencorse, Thora A.; Hicks, Andrew A.; Hunt, Stephen P.; Barnard, Eric A.; Darlison, Mark G.

Abstract

We report the sequence of a complementary {DNA} (cDNA) that encodes the chicken {GABAA} receptor α1 subunit, which is extremely homologous to mammalian α1 subunits. The distribution of α1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the α1 subunit may not necessarily be restricted to receptors having {BZI} pharmacology.

• Journal Article Type: Article
• Publication Date: 1991-03
• Deposit Date: Jul 27, 2016
• Journal: Molecular Brain Research
• Print ISSN: 0169-328X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 4
• Pages: 333-339
• DOI: https://doi.org/10.1016/0169-328x%2891%2990081-8
• Keywords: Benzodiazepine pharmacology, cDNA cloning, Chicken brain, GABAA receptor, In situ hybridization, Receptor subtype,
• Public URL: http://researchrepository.napier.ac.uk/Output/317411
• Publisher URL: http://www.sciencedirect.com/science/article/pii/0169328X91900818