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Consequences of the Evolution of the GABAA Receptor Gene Family

Darlison, Mark G.; Pahal, Inderjit; Thode, Christian

Authors

Mark G. Darlison

Inderjit Pahal

Christian Thode



Abstract

1. This paper reviews the evolution of the family of genes present in mammals and other vertebrates that encode $γ$-aminobutyric acid (GABA) type A (GABAA) receptors, which are the major inhibitory neurotransmitter receptors in the central nervous system (CNS). In mammals, 16 different polypeptides ($α$1--$α$6, $β$1--$β$3, $γ$1--$γ$3, $δ$, $ε$, $π$, and $θ$) have been identified, using recombinant DNA techniques, each of which is encoded by a distinct gene. The products of these genes assemble in diverse combinations to form a variety of receptor subtypes that have different sensitivities to a number of clinically relevant compounds, such as the benzodiazepines (BZs).

Journal Article Type Article
Acceptance Date Apr 14, 2004
Publication Date 2005-06
Deposit Date Jul 26, 2016
Journal Cellular and Molecular Neurobiology
Print ISSN 0272-4340
Electronic ISSN 1573-6830
Publisher BMC
Peer Reviewed Peer Reviewed
Volume 25
Issue 3-4
Pages 607-624
DOI https://doi.org/10.1007/s10571-005-4004-4
Keywords evolution, GABAA receptor, gene duplication, gene mapping, gene promoter, imprinting training, ligand-gated ion channel, multigene family, neurotransmitter receptor,
Public URL http://researchrepository.napier.ac.uk/Output/316461
Related Public URLs http://dx.doi.org/10.1007/s10571-005-4004-4