Mark G. Darlison
Consequences of the Evolution of the GABAA Receptor Gene Family
Darlison, Mark G.; Pahal, Inderjit; Thode, Christian
Authors
Inderjit Pahal
Christian Thode
Abstract
1. This paper reviews the evolution of the family of genes present in mammals and other vertebrates that encode $γ$-aminobutyric acid (GABA) type A (GABAA) receptors, which are the major inhibitory neurotransmitter receptors in the central nervous system (CNS). In mammals, 16 different polypeptides ($α$1--$α$6, $β$1--$β$3, $γ$1--$γ$3, $δ$, $ε$, $π$, and $θ$) have been identified, using recombinant DNA techniques, each of which is encoded by a distinct gene. The products of these genes assemble in diverse combinations to form a variety of receptor subtypes that have different sensitivities to a number of clinically relevant compounds, such as the benzodiazepines (BZs).
Citation
Darlison, M. G., Pahal, I., & Thode, C. (2005). Consequences of the Evolution of the GABAA Receptor Gene Family. Cellular and Molecular Neurobiology, 25(3-4), 607-624. https://doi.org/10.1007/s10571-005-4004-4
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 14, 2004 |
Publication Date | 2005-06 |
Deposit Date | Jul 26, 2016 |
Journal | Cellular and Molecular Neurobiology |
Print ISSN | 0272-4340 |
Electronic ISSN | 1573-6830 |
Publisher | BMC |
Peer Reviewed | Peer Reviewed |
Volume | 25 |
Issue | 3-4 |
Pages | 607-624 |
DOI | https://doi.org/10.1007/s10571-005-4004-4 |
Keywords | evolution, GABAA receptor, gene duplication, gene mapping, gene promoter, imprinting training, ligand-gated ion channel, multigene family, neurotransmitter receptor, |
Public URL | http://researchrepository.napier.ac.uk/Output/316461 |
Related Public URLs | http://dx.doi.org/10.1007/s10571-005-4004-4 |
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