Skip to main content

Research Repository

Advanced Search

Outputs (120)

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure (2007)
Journal Article
Barlow, P. G., Brown, D. M., Donaldson, K., MacCallum, J., & Stone, V. (2008). Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24(3), 243-252. https://doi.org/10.1007/s10565-007-9033-y

Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiovascular disorders. The exact mechanism by which PM10 drives toxicity in the... Read More about Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure.

Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation (2007)
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007). Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012

Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals can potentiate the ability of nanoparticles to induce lung inflammation and... Read More about Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation.

Impact of atmospheric ozone-enrichment on quality-related attributes of tomato fruit (2007)
Journal Article
Tzortzakis, N., Borland, A., Singleton, I., & Barnes, J. (2007). Impact of atmospheric ozone-enrichment on quality-related attributes of tomato fruit. Postharvest Biology and Technology, 45(3), 317-325. https://doi.org/10.1016/j.postharvbio.2007.03.004

Tomato fruit (Lycopersicon esculentum L. cv. Carousel) were exposed to ozone concentrations ranging between 0.005 (controls) and 1.0 μmol mol−1 at 13 °C and 95% RH. Quality-related attributes and organoleptic characteristics were examined during and... Read More about Impact of atmospheric ozone-enrichment on quality-related attributes of tomato fruit.

Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. (2007)
Journal Article
Lin, Y., Stevens, C., & Hupp, T. (2007). Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. Journal of Biological Chemistry, 282(23), 16792-16802. https://doi.org/10.1074/jbc.M611559200

DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 protein regulation, we have determined that DAPK-1 protein has a long half-life... Read More about Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis..

Deployment of low-level ozone-enrichment for the preservation of chilled fresh produce (2007)
Journal Article
Tzortzakis, N., Singleton, I., & Barnes, J. (2007). Deployment of low-level ozone-enrichment for the preservation of chilled fresh produce. Postharvest Biology and Technology, 43(2), 261-270. https://doi.org/10.1016/j.postharvbio.2006.09.005

Tomatoes, strawberries, table grapes and plums were inoculated with Botrytis cinerea (grey mould), transferred to chilled storage (13 °C) and exposed to ‘clean air’ or low-level ozone-enrichment (0.1 μmol mol−1). Ozone-enrichment resulted in a substa... Read More about Deployment of low-level ozone-enrichment for the preservation of chilled fresh produce.

A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis (2007)
Journal Article
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., Durston, V., Eccles, D. M., & Hupp, T. (2007). A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry, 282(18), 13791-13803. https://doi.org/10.1074/jbc.m605649200

p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the mechanism of DAPK-1 control, a novel mutation (N1347S) was identified in the... Read More about A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis.

Rapid quantification of polycyclic aromatic hydrocarbons in hydroxypropyl-β-cyclodextrin (HPCD) soil extracts by synchronous fluorescence spectroscopy (SFS) (2007)
Journal Article
Hua, G., Broderick, J., Semple, K. T., Killham, K., & Singleton, I. (2007). Rapid quantification of polycyclic aromatic hydrocarbons in hydroxypropyl-β-cyclodextrin (HPCD) soil extracts by synchronous fluorescence spectroscopy (SFS). Environmental Pollution, 148(1), 176-181. https://doi.org/10.1016/j.envpol.2006.10.040

Synchronous fluorescence spectroscopy (SFS) was directly applied to rapidly quantify selected polycyclic aromatic hydrocarbons (PAHs: benzo[a]pyrene and pyrene) in aqueous hydroxypropyl-β-cyclodextrin (HPCD) soil extract solutions from a variety of a... Read More about Rapid quantification of polycyclic aromatic hydrocarbons in hydroxypropyl-β-cyclodextrin (HPCD) soil extracts by synchronous fluorescence spectroscopy (SFS).

Supplementary biochemical tests useful for the differentiation of oxidase positive staphylococci (2007)
Journal Article
Stepanović, S., Dakić, I., Hauschild, T., Vuković, D., Morrison, D., Ježek, P., Ćirković, I., & Petráš, P. (2007). Supplementary biochemical tests useful for the differentiation of oxidase positive staphylococci. Systematic and Applied Microbiology, 30(4), 316-318. https://doi.org/10.1016/j.syapm.2006.11.002

Differentiation of the oxidase positive staphylococci, Staphylococcus sciuri, Staphylococcus lentus, Staphylococcus vitulinus and Staphylococcus fleurettii, based on tributyrin, urease, caseinase, gelatinase and DNase activity is described. These tes... Read More about Supplementary biochemical tests useful for the differentiation of oxidase positive staphylococci.

Spread of a single multiresistant methicillin-resistant Staphylococcus aureus clone carrying a variant of staphylococcal cassette chromosome mec type III isolated in a university hospital (2006)
Journal Article
Szczepanik, A., Kozioł-Montewka, M., Al-Doori, Z., Morrison, D., & Kaczor, D. (2007). Spread of a single multiresistant methicillin-resistant Staphylococcus aureus clone carrying a variant of staphylococcal cassette chromosome mec type III isolated in a university hospital. European Journal of Clinical Microbiology and Infectious Diseases, 26(1), 29-35. https://doi.org/10.1007/s10096-006-0237-5

The purpose of the study was the molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) isolates cultured from patients treated in seven wards of a university hospital in Lublin, Poland, over a 14-month period. Eleven nosoco... Read More about Spread of a single multiresistant methicillin-resistant Staphylococcus aureus clone carrying a variant of staphylococcal cassette chromosome mec type III isolated in a university hospital.

Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam. (2006)
Journal Article
Soddell, J. A., Stainsby, F. M., Eales, K. L., Seviour, R. J., & Goodfellow, M. (2006). Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam. International Journal of Systematic and Evolutionary Microbiology, 56, 2265-2269. https://doi.org/10.1099/ijs.0.64034-0

Three strains of non-motile, Gram-positive, filamentous actinomycetes, isolates J4T, J5 and J59, initially recognized microscopically in activated sludge foam by their distinctive branching patterns, were isolated by micromanipulation. The taxonomic... Read More about Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam..

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system (2006)
Journal Article
Barlow, P. G., Li, Y., Wilkinson, T. S., Bowdish, D. M. E., Lau, Y. E., Cosseau, C., Haslett, C., Simpson, A. J., Hancock, R. E. W., & Davidson, D. J. (2006). The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. Journal of Leukocyte Biology, 80(3), 509-520. https://doi.org/10.1189/jlb.1005560

The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide) expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under conditions of inflammation, has immunomodulatory and antimicrobial funct... Read More about The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

Molecular identification and characterization of mannitol-negative methicillin-resistant Staphylococcus aureus (2006)
Journal Article
Shittu, A., Lin, J., & Morrison, D. (2007). Molecular identification and characterization of mannitol-negative methicillin-resistant Staphylococcus aureus. Diagnostic Microbiology and Infectious Disease, 57(1), 93-95. https://doi.org/10.1016/j.diagmicrobio.2006.05.004

We report on the isolation, molecular identification, and characterization of 5 mannitol-negative methicillin-resistant Staphylococcus aureus (MRSA) from clinical samples in KwaZulu-Natal (KZN) province, South Africa. Identification based on phenotyp... Read More about Molecular identification and characterization of mannitol-negative methicillin-resistant Staphylococcus aureus.

Identifying contemporary and historic sources of soil polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in an industrial urban setting (2006)
Journal Article
Vizard, C. G., Rimmer, D. L., Pless-Mulloli, T., Singleton, I., & Air, V. S. (2006). Identifying contemporary and historic sources of soil polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in an industrial urban setting. Science of the Total Environment, 370(1), 61-69. https://doi.org/10.1016/j.scitotenv.2006.06.006

A study of soil polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) concentrations was undertaken in the vicinity of a municipal solid waste incinerator (MSWI) in Newcastle upon Tyne as a result of concerns raised by local re... Read More about Identifying contemporary and historic sources of soil polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in an industrial urban setting.

Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. (2005)
Journal Article
Barlow, P. G., Clouter-Baker, A., Donaldson, K., MacCallum, J., & Stone, V. (2005). Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and fibre toxicology, 2(1), 11-24. https://doi.org/10.1186/1743-8977-2-11

Background - Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanoparticles are considered a potential threat to the lungs and the mechanism of... Read More about Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages..

Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration (2004)
Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005). Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.11.006

Objective:
To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a model previously reported to investigate complement activation by other respir... Read More about Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration.

Parasitic helminths tip the balance: potential anti-inflammatory therapies (2004)
Journal Article
Proudfoot, L. (2004). Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology, 113(4), 438-440. https://doi.org/10.1111/j.1365-2567.2004.01996.x

Parasitic helminths are worms that are classified within the phyla Nematoda (roundworms) and Platyhelminthes (flatworms) (see Table 1). Some nematode species, Filariae being a notable example, are able to coexist with their human host for decades. In... Read More about Parasitic helminths tip the balance: potential anti-inflammatory therapies.

Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. (2003)
Journal Article
Dancer, S. J., Robb, A., Crawford, A., & Morrison, D. (2003). Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Antimicrobial Chemotherapy, 51, 731-735. https://doi.org/10.1093/jac/dkg143

Objectives: Chronic methicillin-resistant Staphylococcus aureus (MRSA) infections in debilitated patients are difficult to treat. We studied the clinical efficacy and safety of an oral streptogramin, pristinamycin, for these patients.

Patients an... Read More about Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections..

Chk2 activates E2F-1 in response to DNA damage (2003)
Journal Article
Stevens, C., Smith, L., & La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409. https://doi.org/10.1038/ncb974

The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. A Chk2 c... Read More about Chk2 activates E2F-1 in response to DNA damage.