Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections.

Dancer, S J; Robb, A; Crawford, A; Morrison, Donald

Abstract

Objectives: Chronic methicillin-resistant Staphylococcus aureus (MRSA) infections in debilitated patients are difficult to treat. We studied the clinical efficacy and safety of an oral streptogramin, pristinamycin, for these patients.

Patients and methods: Patients were admitted consecutively to receive pristinamycin, usually with doxycycline, for 7–21 days. Fifty-six patients (average age 75 years) from hospital and community were treated for skin, soft tissue, chest and other infections.

Results: The overall clinical response rate was 39 of 53 patients (74%; 95% CI: 60%, 85%) cured or substantially improved, from 53 of 56 (95%) patients clinically and 49 of 56 (87.5%) patients bacteriologically evaluable. Toxic effects comprised gastrointestinal disturbances in eight patients (14%) and one (2%) possible skin rash.

Conclusion: This study suggests that oral streptogramins may be useful in the management of debilitated patients with MRSA infections

Citation

Dancer, S. J., Robb, A., Crawford, A., & Morrison, D. (2003). Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Antimicrobial Chemotherapy, 51, 731-735. https://doi.org/10.1093/jac/dkg143

• Journal Article Type: Article
• Publication Date: 2003
• Deposit Date: Jun 12, 2015
• Print ISSN: 0305-7453
• Electronic ISSN: 1460-2091
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 51
• Pages: 731-735
• DOI: https://doi.org/10.1093/jac/dkg143
• Keywords: Oral streptogramins; MRSA infections
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/8670
• Publisher URL: http://dx.doi.org/10.1093/jac/dkg143