Prof Stephanie Dancer S.Dancer@napier.ac.uk
Professor
Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections.
Dancer, S J; Robb, A; Crawford, A; Morrison, Donald
Authors
A Robb
A Crawford
Dr Donald Morrison D.Morrison2@napier.ac.uk
Lecturer
Abstract
Objectives: Chronic methicillin-resistant Staphylococcus aureus (MRSA) infections in debilitated patients are difficult to treat. We studied the clinical efficacy and safety of an oral streptogramin, pristinamycin, for these patients.
Patients and methods: Patients were admitted consecutively to receive pristinamycin, usually with doxycycline, for 7–21 days. Fifty-six patients (average age 75 years) from hospital and community were treated for skin, soft tissue, chest and other infections.
Results: The overall clinical response rate was 39 of 53 patients (74%; 95% CI: 60%, 85%) cured or substantially improved, from 53 of 56 (95%) patients clinically and 49 of 56 (87.5%) patients bacteriologically evaluable. Toxic effects comprised gastrointestinal disturbances in eight patients (14%) and one (2%) possible skin rash.
Conclusion: This study suggests that oral streptogramins may be useful in the management of debilitated patients with MRSA infections
Citation
Dancer, S. J., Robb, A., Crawford, A., & Morrison, D. (2003). Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Antimicrobial Chemotherapy, 51, 731-735. https://doi.org/10.1093/jac/dkg143
Journal Article Type | Article |
---|---|
Publication Date | 2003 |
Deposit Date | Jun 12, 2015 |
Print ISSN | 0305-7453 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 51 |
Pages | 731-735 |
DOI | https://doi.org/10.1093/jac/dkg143 |
Keywords | Oral streptogramins; MRSA infections; |
Public URL | http://researchrepository.napier.ac.uk/id/eprint/8670 |
Publisher URL | http://dx.doi.org/10.1093/jac/dkg143 |
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