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Rheological spectroscopy of concentrated colloidal dispersions (1993)
Journal Article
Williams, P., Williams, D., & Williams, R. (1993). Rheological spectroscopy of concentrated colloidal dispersions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 77(1), 75-79. https://doi.org/10.1016/0927-7757%2893%2980101-j

A new instrument, the virtual gap rheometer (VGR) for the determination of dynamic shear moduli (and mechanical relaxation spectra therefrom) at frequencies above 100 Hz is described. Several features of the VGR which make it particularly suited to t... Read More about Rheological spectroscopy of concentrated colloidal dispersions.

Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes (1989)
Journal Article
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes. Molecular Brain Research, 5(4), 305-310. https://doi.org/10.1016/0169-328x%2889%2990065-x

The distribution of 3 {GABAA} receptor α-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the α2- and α3-transcripts are of low abundance in all regions except striatum, the α1-transcript is... Read More about Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes.

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease (1989)
Journal Article
Buckle, V. J., Fujita, N., Ryder-Cook, A. S., Derry, J. M., Barnard, P. J., Lebo, R. V., Schofield, P. R., Seeburg, P. H., Bateson, A. N., Darlison, M. G., & Barnard, E. A. (1989). Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron, 3(5), 647-654. https://doi.org/10.1016/0896-6273%2889%2990275-4

Hybridization of {GABAA} receptor probes to human chromosomes in situ and to {DNA} from sorted human chromosomes has localized the genes encoding a β subunit and three isoforms of the a subunit. The α2 and β genes are both located on chromosome 4 in... Read More about Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.

The molecular basis of muscular dystrophy in the mdx mouse: a point mutation (1989)
Journal Article
Sicinski, P., Geng, Y., Ryder-Cook, A., Barnard, E., Darlison, M., & Barnard, P. (1989). The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science, 244(4912), 1578-1580. https://doi.org/10.1126/science.2662404

The mdx mouse is an X-linked myopathic mutant, an animal model for human Duchenne muscular dystrophy. In both mouse and man the mutations lie within the dystrophin gene, but the phenotypic differences of the disease in the two species confer much int... Read More about The molecular basis of muscular dystrophy in the mdx mouse: a point mutation.

Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer (1989)
Journal Article
Wisden, W., McNaughton, L. A., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer. Neuroscience Letters, 106(1-2), 7-12. https://doi.org/10.1016/0304-3940%2889%2990193-6

Using in situ hybridization histochemistry, we have demonstrated that 3 α subunit mRNAs of the {GABAA} receptor are present in different cell populations of the bovine cerebellum. While the α1 mRNA is the most abundant and is present in granule cells... Read More about Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer.

Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28 (1991)
Journal Article
Herman, G. E., Faust, C. J., Darlison, M. G., & Barnard, E. A. (1991). Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28. Genomics, 9(4), 670-677. https://doi.org/10.1016/0888-7543%2891%2990360-q

The four loci Gabra3, DXPas8, CamL1, and Bpa, located near the murine X-linked visual pigment gene (Rsup), have been ordered using 248 backcross progeny from an interspecific mating of (B6CBA-Aw-JA-Bpa) and Mus spretus. One hundred twenty backcross p... Read More about Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28.

Distinct regional expression of nicotinic acetylcholine receptor genes in chick brain (1990)
Journal Article
Morris, B. J., Hicks, A. A., Wisden, W., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1990). Distinct regional expression of nicotinic acetylcholine receptor genes in chick brain. Molecular Brain Research, 7(4), 305-315. https://doi.org/10.1016/0169-328x%2890%2990081-n

Four genes (α2, α3, α4 and β2) have been reported as encoding subunits of the nicotinic acetylcholine receptor (nAChR) in chicken brain. The mRNAs transcribed from these genes have here been localised to particular regions using in situ hybridisation... Read More about Distinct regional expression of nicotinic acetylcholine receptor genes in chick brain.

Amino acid receptors from insect muscle: electrophysiological characterization in Xenopus oocytes following expression by injection of mRNA (1990)
Journal Article
Fraser, S., Djamgoz, M., Usherwood, P., O'Brien, J., Darlison, M., & Barnard, E. (1990). Amino acid receptors from insect muscle: electrophysiological characterization in Xenopus oocytes following expression by injection of mRNA. Molecular Brain Research, 8(4), 331-341. https://doi.org/10.1016/0169-328x%2890%2990047-h

Poly(A)+ messenger ribonucleic acid (mRNA) was extracted from leg muscles of the locust Schistocerca gregaria and injected into oocytes of Xenopus laevis. After 5–10 days incubation, receptors for l-glutamate, l-quisqualate, dl-ibotenate and γ-aminob... Read More about Amino acid receptors from insect muscle: electrophysiological characterization in Xenopus oocytes following expression by injection of mRNA.

The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA (1991)
Journal Article
Bateson, A. N., Harvey, R. J., Wisden, W., Glencorse, T. A., Hicks, A. A., Hunt, S. P., Barnard, E. A., & Darlison, M. G. (1991). The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA. Molecular Brain Research, 9(4), 333-339. https://doi.org/10.1016/0169-328x%2891%2990081-8

We report the sequence of a complementary {DNA} (cDNA) that encodes the chicken {GABAA} receptor α1 subunit, which is extremely homologous to mammalian α1 subunits. The distribution of α1 subunit transcripts is shown to correlate mainly, but not comp... Read More about The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA.

y-Aminobutyric AcidA Receptor Heterogeneity Is Increased by Alternative Splicing of a Novel ?-Subunit Gene Transcript (1991)
Journal Article
Bateson, A. N., Lasham, A., & Darlison, M. G. (1991). y-Aminobutyric AcidA Receptor Heterogeneity Is Increased by Alternative Splicing of a Novel ?-Subunit Gene Transcript. Journal of Neurochemistry, 56(4), 1437-1440. https://doi.org/10.1111/j.1471-4159.1991.tb11443.x

Abstract: DNA sequences encoding two variants of a novel γ-aminobutyric acidA (GABAA) receptor β subunit were isolated from an embryonic chicken whole-brain cDNA library and a chicken genomic library. The coding regions of these variants only differ... Read More about y-Aminobutyric AcidA Receptor Heterogeneity Is Increased by Alternative Splicing of a Novel ?-Subunit Gene Transcript.

Conserved Organization of ?-Aminobutyric AcidAReceptor Genes: Cloning and Analysis of the Chicken ?4-Subunit Gene (1991)
Journal Article
Lasham, A., Vreugdenhil, E., Bateson, A. N., Barnard, E. A., & Darlison, M. G. (1991). Conserved Organization of ?-Aminobutyric AcidAReceptor Genes: Cloning and Analysis of the Chicken ?4-Subunit Gene. Journal of Neurochemistry, 57(1), 352-355. https://doi.org/10.1111/j.1471-4159.1991.tb02135.x

Abstract: A series of genomic clones containing DNA that encodes the chicken γ-aminobutyric acidA (GABAA) receptor β4 subunit have been isolated. These have been restriction mapped and partially sequcnced to determine the structural organization and... Read More about Conserved Organization of ?-Aminobutyric AcidAReceptor Genes: Cloning and Analysis of the Chicken ?4-Subunit Gene.

Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain (1992)
Journal Article
Glencorse, T. A., Bateson, A. N., & Darlison, M. G. (1992). Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain. European Journal of Neuroscience, 4(3), 271-277. https://doi.org/10.1111/j.1460-9568.1992.tb00874.x

Two variants of the GABAA receptor γ2 subunit are known to exist, which differ by the presence (γ2L) or absence (γ2S) of eight amino acids in the presumed intracellular loop between the third and fourth membrane-spanning domains. These variants have... Read More about Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain.

Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid (1992)
Journal Article
Zaman, S. H., Shingai, R., Harvey, R. J., Darlison, M. G., & Barnard, E. A. (1992). Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid. European journal of pharmacology. Molecular pharmacology section, 225(4), 321-330. https://doi.org/10.1016/0922-4106%2892%2990106-6

When vertebrate brain poly(A)+ RNA is expressed in Xenopus oocytes the response of the GABA receptors formed is found to be inhibited allosterically by a neurosteroid, pregnenolone sulphate (PS). This negative modulation was reproduced after expressi... Read More about Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.

Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel (1992)
Journal Article
Traupe, H., Ouweland, A. M. V. D., Oost, B. A. V., Vogel, W., Vetter, U., Warren, S. T., Rocchi, M., Darlison, M. G., & Ropers, H. (1992). Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. Genomics, 13(2), 481-483. https://doi.org/10.1016/0888-7543%2892%2990279-2

Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The human gene for biglycan (BGN) has previously been mapped by in situ hybridizat... Read More about Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel.

Fungal interactions with metals and radionuclides for environmental bioremediation (1996)
Book Chapter
Singleton, I., & Tobin, J. M. (1996). Fungal interactions with metals and radionuclides for environmental bioremediation. In J. C. Frankland, N. Magan, & G. M. Gadd (Eds.), Fungi and environmental change (282-298). Cambridge University Press. https://doi.org/10.1017/CBO9780511753190.018

Microorganisms, including fungi, are known to accumulate metals from their external environment and the possibility of using fungi as a means of treating metal/radionuclide-containing effluents is well recognized (Siegel, Galun & Siegel, 1990; Gadd,... Read More about Fungal interactions with metals and radionuclides for environmental bioremediation.

Fungal remediation of soils contaminated with persistent organic pollutants (2001)
Book Chapter
Singleton, I. (2001). Fungal remediation of soils contaminated with persistent organic pollutants. In G. M. Gadd (Ed.), Fungi in Bioremediation, (79-96). Cambridge: Cambridge University Press. https://doi.org/10.1017/CBO9780511541780.005

Laboratory-based studies have shown that fungi are able to degrade a wide range of organic pollutants (see other chapters) and have great potential for use as inoculants to remediate contaminated soil. However, soil is a heterogeneous environment and... Read More about Fungal remediation of soils contaminated with persistent organic pollutants.