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Expression of transforming growth factor beta mRNA isoforms in human breast cancer (1994)
Journal Article
MacCallum, J., Bartlett, J., Thompson, A., Keen, J., Dixon, J., & Miller, W. (1994). Expression of transforming growth factor beta mRNA isoforms in human breast cancer. British Journal of Cancer, 69(6), 1006-1009. https://doi.org/10.1038/bjc.1994.197

Using an RNAse protection assay, expression of messenger RNA for isoforms of TGF-beta was determined in a series of breast cancers. Of 50 tumours, 45 (90%) expressed TGF-beta 1 mRNA, 39 (78%) expressed TGF-beta 2, and 47 (94%) expressed TGF-beta 3. P... Read More about Expression of transforming growth factor beta mRNA isoforms in human breast cancer.

Further Evidence for Clustering of Human GABAA Receptor Subunit Genes: Localization of the α6-Subunit Gene (GABRA6) to Distal Chromosome 5q by Linkage Analysis (1994)
Journal Article
Hicks, A. A., Bailey, M. E., Riley, B. P., Kamphuis, W., Siciliano, M. J., Johnson, K. J., & Darlison, M. G. (1994). Further Evidence for Clustering of Human GABAA Receptor Subunit Genes: Localization of the α6-Subunit Gene (GABRA6) to Distal Chromosome 5q by Linkage Analysis. Genomics, 20(2), 285-288. https://doi.org/10.1006/geno.1994.1167

GABAA receptors are hetero-oligomeric ion-channel complexes that are composed of combinations of α, β, γ, and δ subunits and play a major role in inhibitory neurotransmission in the mammalian brain. We report here a microsatellite polymorphism within... Read More about Further Evidence for Clustering of Human GABAA Receptor Subunit Genes: Localization of the α6-Subunit Gene (GABRA6) to Distal Chromosome 5q by Linkage Analysis.

Microbial metabolism of xenobiotics: Fundamental and applied research (1994)
Journal Article
Singleton, I. (1994). Microbial metabolism of xenobiotics: Fundamental and applied research. Journal of Chemical Technology and Biotechnology, 59(1), 9-23. doi:10.1002/jctb.280590104

The ability of microorganisms to metabolise xenobiotic compounds has received much attention due to the environmental persistence and toxicity of these chemicals. The microbial degradation of xenobiotics is seen as a cost effective method of removing... Read More about Microbial metabolism of xenobiotics: Fundamental and applied research.

Alternative Splicing of a 51-Nucleotide Exon that Encodes a Putative Protein Kinase C Phosphorylation Site Generates Two Forms of the Chicken γ-Aminobutyric AcidAReceptor β2 Subunit (1994)
Journal Article
Harvey, R. J., Chinchetru, M. A., & Darlison, M. G. (1994). Alternative Splicing of a 51-Nucleotide Exon that Encodes a Putative Protein Kinase C Phosphorylation Site Generates Two Forms of the Chicken γ-Aminobutyric AcidAReceptor β2 Subunit. Journal of Neurochemistry, 62(1), 10-16. https://doi.org/10.1046/j.1471-4159.1994.62010010.x

Complementary DNAs that encode two forms of the chicken -γ-aminobutyric acid type A (GABAA) receptor β2 subunit have been isolated. These polypeptides differ by the presence (β2L) or absence (β2S) of 17 amino acids, which contain a possible target fo... Read More about Alternative Splicing of a 51-Nucleotide Exon that Encodes a Putative Protein Kinase C Phosphorylation Site Generates Two Forms of the Chicken γ-Aminobutyric AcidAReceptor β2 Subunit.

Phenotypic and phylogenetic characterisation of some Gemella-like organisms from human infections: description of Dolosigranulum pigrum gen. nov., sp. nov. (1993)
Journal Article
Aguirre, M., Morrison, D., Cookson, B. D., Gay, F. W. & Collins, M. D. (1992). Phenotypic and phylogenetic characterisation of some Gemella-like organisms from human infections: description of Dolosigranulum pigrum gen. nov., sp. nov. The journal of applied bacteriology. 75. . 608-612. . ISSN 0021-8847.

A phylogenetic analysis was performed on two previously uncharacterized Gram-positive, catalase-negative bacteria from clinical sources. 16S rRNA sequencing studies revealed the isolates represent a new line of descent within the lactic acid group of... Read More about Phenotypic and phylogenetic characterisation of some Gemella-like organisms from human infections: description of Dolosigranulum pigrum gen. nov., sp. nov..

Antimicrobial resistance amongst enterococci isolated in the United Kingdom: a reference laboratory perspective. (Comment in Vancomycin-dependent enterococci in the United Kingdom J Antimicrob Chemother. 1994 ) (1993)
Journal Article
Woodford, N., Morrison, D., Johnson, A. P. & George, R. C. (1992). Antimicrobial resistance amongst enterococci
isolated in the United Kingdom: a reference
laboratory perspective. (Comment in Vancomycin-dependent enterococci in the United Kingdom J Antimicrob Chemother. 1994 ). Journal of Antimicrobial Chemotherapy. 32. . 344-346. . ISSN 0305-7453.

Sequence and Novel Distribution of the Chicken Homologue of the Mammalianγ-Aminobutyric AcidAReceptorγ1 Subunit (1993)
Journal Article
Glencorse, T. A., Darlison, M. G., Barnard, E. A., & Bateson, A. N. (1993). Sequence and Novel Distribution of the Chicken Homologue of the Mammalianγ-Aminobutyric AcidAReceptorγ1 Subunit. Journal of Neurochemistry, 61(6), 2294-2302. https://doi.org/10.1111/j.1471-4159.1993.tb07473.x

cDNAs have been cloned that encode the chicken (Gallus domesticus) γ-aminobutyric acidA receptor γ1 subunit, the mature sequence of which shares 90, 79, and 69% identity with those of the rat γ1, γ2., and γ3 subunits, respectively. In situ hybridizat... Read More about Sequence and Novel Distribution of the Chicken Homologue of the Mammalianγ-Aminobutyric AcidAReceptorγ1 Subunit.

Molluscan ligand-gated ion-channel receptors (1993)
Book Chapter
Darlison, M. G., Hutton, M. L., & Harvey, R. J. (1993). Molluscan ligand-gated ion-channel receptors. In Comparative Molecular Neurobiology, 48-64. Springer Verlag. https://doi.org/10.1007/978-3-0348-7265-2_3

In this chapter we introduce the reader to the structures of the different types of ligand-gated ion-channel receptor, and the numerous receptor subtypes that have recently been revealed to exist, in both invertebrate and vertebrate species, by the a... Read More about Molluscan ligand-gated ion-channel receptors.

External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment (1993)
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., & Kennedy, M. W. (1993). External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment. Parasitology, 107(05), 559. https://doi.org/10.1017/s0031182000068141

Previous work has shown that the surface of infective larvae of parasitic nematodes will not bind the fluorescent lipid analogue 5-N(octadecanoyl)aminofluorescein (AF18) until after exposure of the parasite to mammalian tissue-culture conditions. In... Read More about External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment.

Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor (1993)
Journal Article
Harvey, R. J., Kim, H., & Darlison, M. G. (1993). Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor. FEBS Letters, 331(3), 211-216. https://doi.org/10.1016/0014-5793%2893%2980339-v

We have isolated a cDNA, from the chicken, that encodes a fourth type of γ subunit of the vertebrate brain GABAA receptor. The mature polypeptide (which we name γ4) displays 67%, 69% and 70% identity, respectively, to the rat γ1, γ2 and γ3 subunits.... Read More about Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor.

Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms (1993)
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1993). Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms. Parasitology, 107(01), 107. https://doi.org/10.1017/s0031182000079464

All mammalian-parasitic stages of a range of nematode species investigated (Brugia pahangi, Acanthocheilonema viteae, Strongyloides ratti, Nippostrongylus brasiliensis, Trichinella spiralis and Ostertagia ostertagi) labelled in a surface-restricted m... Read More about Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms.

A novel invertebrate GABAAreceptor-like polypeptide Sequence and pattern of gene expression (1993)
Journal Article
Hutton, M. L., Harvey, R. J., Earley, F. G., Barnard, E. A., & Darlison, M. G. (1993). A novel invertebrate GABAAreceptor-like polypeptide Sequence and pattern of gene expression. FEBS Letters, 326(1-3), 112-116. https://doi.org/10.1016/0014-5793%2893%2981773-s

A full‐length complementary DNA has been isolated, from the fresh‐water mollusc Lymnaea stagnalis, that encodes a polypeptide (which we have named Ç) that exhibits between 30% and 40% identity to vertebrate GABAA and glycine receptor subunit sequence... Read More about A novel invertebrate GABAAreceptor-like polypeptide Sequence and pattern of gene expression.

Incompatibility properties of the narrow-host-range lactococcal plasmid pCI305. (1993)
Journal Article
Foley, S., Daly, C., & Fitzgerald, G. F. (1993). Incompatibility properties of the narrow-host-range lactococcal plasmid pCI305. The Journal of general microbiology, 139, 1271-1276. https://doi.org/10.1099/00221287-139-6-1271

The cryptic plasmid pCI305 from Lactococcus Zuctis subsp. lactis UC317 was screened for incompatibility with
a range of cloning vectors and was found to be incompatible with the theta-replicating plasmids pAM401 and
pIL253. In contrast, lactococcal... Read More about Incompatibility properties of the narrow-host-range lactococcal plasmid pCI305..

The influence of Cryptocotyle lingua (Digenea:Platyhelminthes) infections on the survival and fecundity of Littorina littorea (Gastropoda:Prosobranchia); an ecological approach (1993)
Journal Article
Huxham, M., Raffaelli, D., & Pike, A. (1993). The influence of Cryptocotyle lingua (Digenea:Platyhelminthes) infections on the survival and fecundity of Littorina littorea (Gastropoda:Prosobranchia); an ecological approach. Journal of Experimental Marine Biology and Ecology, 168(2), (223-238). doi:10.1016/0022-0981(93)90262-m. ISSN 0022-0981

This study considers the impact of digenean parasites, especially Cryptocotyle lingua (Creplin) on the survival, reproduction, growth rate and foot colour of Littorina littorea (Forbes and Hanley). An 18 month field experiment demonstrated decreased... Read More about The influence of Cryptocotyle lingua (Digenea:Platyhelminthes) infections on the survival and fecundity of Littorina littorea (Gastropoda:Prosobranchia); an ecological approach.

Comparison of high-level gentamicin resistant (HLGR) Enterococcus faecium isolates from different continents. (1993)
Journal Article
Woodford, N., Morrison, D., Cookson, B. D. & George, R. C. (1993). Comparison of high-level gentamicin resistant (HLGR) Enterococcus faecium isolates from different continents. Antimicrobial Agents and Chemotherapy. 37. . 681-684. . ISSN 0066-4804.

Eight clinical isolates of Enterococcus faecium highly resistant to gentamicin (MIC, > 1,000 mg/liter) from patients in six hospitals on three continents were investigated for evidence of spread of either a clone of high-level gentamicin-resistant (H... Read More about Comparison of high-level gentamicin resistant (HLGR) Enterococcus faecium isolates from different continents..