Further Evidence for Clustering of Human GABAA Receptor Subunit Genes: Localization of the α6-Subunit Gene (GABRA6) to Distal Chromosome 5q by Linkage Analysis

Hicks, Andrew A.; Bailey, Mark E.S.; Riley, Brien P.; Kamphuis, Willem; Siciliano, Michael J.; Johnson, Keith J.; Darlison, Mark G.

Abstract

GABAA receptors are hetero-oligomeric ion-channel complexes that are composed of combinations of α, β, γ, and δ subunits and play a major role in inhibitory neurotransmission in the mammalian brain. We report here a microsatellite polymorphism within the human α6-subunit gene (GABRA6). Mapping of this marker in a human-hamster hybrid cell-line panel and typing of the repeat in the Centre d'Étude du Polymorphisme Humain (CEPH) reference families enabled the localization of this gene to chromosome 5q and established its linkage to the GABAA receptor α1-subunit gene (GABRA1) with a maximum lod score (Zmax) of 39.87 at a θ of 0.069 (males) and 0.100 (females). These results reveal the clustering of GABRA6, GABRA1, and the GABAA receptor γ2-subunit gene (GABRG2) on distal chromosome 5q.

Citation

Hicks, A. A., Bailey, M. E., Riley, B. P., Kamphuis, W., Siciliano, M. J., Johnson, K. J., & Darlison, M. G. (1994). Further Evidence for Clustering of Human GABAA Receptor Subunit Genes: Localization of the α6-Subunit Gene (GABRA6) to Distal Chromosome 5q by Linkage Analysis. Genomics, 20(2), 285-288. https://doi.org/10.1006/geno.1994.1167

• Journal Article Type: Article
• Acceptance Date: Mar 1, 1994
• Publication Date: 1994-03
• Deposit Date: Aug 5, 2016
• Journal: Genomics
• Print ISSN: 0888-7543
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 2
• Pages: 285-288
• DOI: https://doi.org/10.1006/geno.1994.1167
• Keywords: Genetics
• Public URL: http://researchrepository.napier.ac.uk/Output/328080