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Further Evidence for Clustering of Human GABAA Receptor Subunit Genes: Localization of the α6-Subunit Gene (GABRA6) to Distal Chromosome 5q by Linkage Analysis

Hicks, Andrew A.; Bailey, Mark E.S.; Riley, Brien P.; Kamphuis, Willem; Siciliano, Michael J.; Johnson, Keith J.; Darlison, Mark G.

Authors

Andrew A. Hicks

Mark E.S. Bailey

Brien P. Riley

Willem Kamphuis

Michael J. Siciliano

Keith J. Johnson

Mark G. Darlison



Abstract

GABAA receptors are hetero-oligomeric ion-channel complexes that are composed of combinations of α, β, γ, and δ subunits and play a major role in inhibitory neurotransmission in the mammalian brain. We report here a microsatellite polymorphism within the human α6-subunit gene (GABRA6). Mapping of this marker in a human-hamster hybrid cell-line panel and typing of the repeat in the Centre d'Étude du Polymorphisme Humain (CEPH) reference families enabled the localization of this gene to chromosome 5q and established its linkage to the GABAA receptor α1-subunit gene (GABRA1) with a maximum lod score (Zmax) of 39.87 at a θ of 0.069 (males) and 0.100 (females). These results reveal the clustering of GABRA6, GABRA1, and the GABAA receptor γ2-subunit gene (GABRG2) on distal chromosome 5q.

Citation

Hicks, A. A., Bailey, M. E., Riley, B. P., Kamphuis, W., Siciliano, M. J., Johnson, K. J., & Darlison, M. G. (1994). Further Evidence for Clustering of Human GABAA Receptor Subunit Genes: Localization of the α6-Subunit Gene (GABRA6) to Distal Chromosome 5q by Linkage Analysis. Genomics, 20(2), 285-288. https://doi.org/10.1006/geno.1994.1167

Journal Article Type Article
Acceptance Date Mar 1, 1994
Publication Date 1994-03
Deposit Date Aug 5, 2016
Journal Genomics
Print ISSN 0888-7543
Electronic ISSN 0888-7543
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 20
Issue 2
Pages 285-288
DOI https://doi.org/10.1006/geno.1994.1167
Keywords Genetics
Public URL http://researchrepository.napier.ac.uk/Output/328080






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