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A novel invertebrate GABAAreceptor-like polypeptide Sequence and pattern of gene expression

Hutton, Michael L.; Harvey, Robert J.; Earley, Fergus G.P.; Barnard, Eric A.; Darlison, Mark G.

Authors

Michael L. Hutton

Robert J. Harvey

Fergus G.P. Earley

Eric A. Barnard

Mark G. Darlison



Abstract

A full‐length complementary DNA has been isolated, from the fresh‐water mollusc Lymnaea stagnalis, that encodes a polypeptide (which we have named Ç) that exhibits between 30% and 40% identity to vertebrate GABAA and glycine receptor subunit sequences. The locations of seven introns have been determined in the corresponding gene and six of these occur at similar relative positions as those found in vertebrate GABAA receptor genes. RNase protection studies have revealed that the transcript for this Lymnaean polypeptide is present at highest levels in the adult nervous system but that it can also be detected in peripheral tissues.

Citation

Hutton, M. L., Harvey, R. J., Earley, F. G., Barnard, E. A., & Darlison, M. G. (1993). A novel invertebrate GABAAreceptor-like polypeptide Sequence and pattern of gene expression. FEBS Letters, 326(1-3), 112-116. https://doi.org/10.1016/0014-5793%2893%2981773-s

Journal Article Type Article
Acceptance Date Jul 1, 1993
Online Publication Date Dec 7, 2001
Publication Date Jul 1, 1993
Deposit Date Aug 5, 2016
Journal FEBS Letters
Print ISSN 0014-5793
Electronic ISSN 1873-3468
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 326
Issue 1-3
Pages 112-116
DOI https://doi.org/10.1016/0014-5793%2893%2981773-s
Keywords Biophysics; Genetics; Cell Biology; Biochemistry; Molecular Biology; Structural Biology
Public URL http://researchrepository.napier.ac.uk/Output/328062






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