Michael L. Hutton
A novel invertebrate GABAAreceptor-like polypeptide Sequence and pattern of gene expression
Hutton, Michael L.; Harvey, Robert J.; Earley, Fergus G.P.; Barnard, Eric A.; Darlison, Mark G.
Authors
Robert J. Harvey
Fergus G.P. Earley
Eric A. Barnard
Mark G. Darlison
Abstract
A full‐length complementary DNA has been isolated, from the fresh‐water mollusc Lymnaea stagnalis, that encodes a polypeptide (which we have named Ç) that exhibits between 30% and 40% identity to vertebrate GABAA and glycine receptor subunit sequences. The locations of seven introns have been determined in the corresponding gene and six of these occur at similar relative positions as those found in vertebrate GABAA receptor genes. RNase protection studies have revealed that the transcript for this Lymnaean polypeptide is present at highest levels in the adult nervous system but that it can also be detected in peripheral tissues.
Citation
Hutton, M. L., Harvey, R. J., Earley, F. G., Barnard, E. A., & Darlison, M. G. (1993). A novel invertebrate GABAAreceptor-like polypeptide Sequence and pattern of gene expression. FEBS Letters, 326(1-3), 112-116. https://doi.org/10.1016/0014-5793%2893%2981773-s
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 1, 1993 |
Online Publication Date | Dec 7, 2001 |
Publication Date | Jul 1, 1993 |
Deposit Date | Aug 5, 2016 |
Journal | FEBS Letters |
Print ISSN | 0014-5793 |
Electronic ISSN | 1873-3468 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 326 |
Issue | 1-3 |
Pages | 112-116 |
DOI | https://doi.org/10.1016/0014-5793%2893%2981773-s |
Keywords | Biophysics; Genetics; Cell Biology; Biochemistry; Molecular Biology; Structural Biology |
Public URL | http://researchrepository.napier.ac.uk/Output/328062 |
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