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Outputs (215)

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia (2017)
Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017). Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), Article e0185664. https://doi.org/10.1371/journal.pone.0185664

Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxygen homeostasis and regulate specific aspects of hypoxic adaptation. Here we... Read More about Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia.

Control of Antimicrobial Resistance Requires an Ethical Approach (2017)
Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017). Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124

Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the prospect of declining anti-infectives affects everyone. Without preventive act... Read More about Control of Antimicrobial Resistance Requires an Ethical Approach.

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., Chambers, G., & Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung (2004)
Thesis
Barlow, P. G. The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/1052591

The effects of inhaled aIr pollution particles on lung clearance mechanisms is an important factor in understanding how the mammalian lung deals with such pollutants and, as such, how exposure to these pollutants can be regulated. The nanoparticle (... Read More about The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung.

Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment (2018)
Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., Entrican, G., McFee, S., Wills, G. S., McClure, M. O., Horner, P. J., Gaikoumelou, S., Lee, K. F., Critchley, H. O., Duncan, W. C., & Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, 29, 159-165. https://doi.org/10.1016/j.ebiom.2018.02.020

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is uncle... Read More about Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment.

How Does a Photocatalytic Antimicrobial Coating Affect Environmental Bioburden in Hospitals? (2018)
Journal Article
Reid, M., Whatley, V., Spooner, E., Nevill, A. M., Cooper, M., Ramsden, J. J., & Dancer, S. J. (2018). How Does a Photocatalytic Antimicrobial Coating Affect Environmental Bioburden in Hospitals?. Infection Control and Hospital Epidemiology, 39(4), 398-404. https://doi.org/10.1017/ice.2017.297

BACKGROUND The healthcare environment is recognized as a source for healthcare-acquired infection. Because cleaning practices are often erratic and always intermittent, we hypothesize that continuously antimicrobial surfaces offer superior control of... Read More about How Does a Photocatalytic Antimicrobial Coating Affect Environmental Bioburden in Hospitals?.

Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men (2018)
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018). Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), Article e13697. https://doi.org/10.14814/phy2.13697

Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31+ T-cells (angiogenic T-cells; TANG) possess highly angiogenic capa... Read More about Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations (2018)
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018). Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), Article 7506. https://doi.org/10.1038/s41598-018-25854-2

Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrophils and whether they trigger damaging inflammation. Neutrophil’s importanc... Read More about Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations.

Antiviral therapeutic approaches for human rhinovirus infections (2018)
Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018). Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016

Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated with bronchiolitis in infants, pneumonia in the immunosuppressed, and exacerba... Read More about Antiviral therapeutic approaches for human rhinovirus infections.

Is there an association between airborne and surface microbes in the critical care environment? (2018)
Journal Article
Smith, J., Adams, C., King, M., Noakes, C., Robertson, C., & Dancer, S. (2018). Is there an association between airborne and surface microbes in the critical care environment?. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2018.04.003

Background There are few data and no accepted standards for air quality in the intensive care unit (ICU). Any relationship between airborne pathogens and hospital-acquired infection (HAI) risk in the ICU remains unknown. Aim First, to correlate en... Read More about Is there an association between airborne and surface microbes in the critical care environment?.

Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity (2018)
Journal Article
Ross, M. D. (2018). Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity. Current Cardiology Reviews, 14(4), 233-244. https://doi.org/10.2174/1573403X14666180726112303

The endothelium plays an important role in cardiovascular regulation, from blood flow, to platelet aggregation, immune cell infiltration and demargination. A dysfunctional endothelium leads to the onset and progression of cardiovascular disease (CVD)... Read More about Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity.

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction (2009)
Journal Article
Lin, Y., Hupp, T. R., & Stevens, C. (2010). Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction. FEBS Journal, 277(1), 48-57. https://doi.org/10.1111/j.1742-4658.2009.07411.x

Death-associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain of DAPK has a range of substrates that mediate its signalli... Read More about Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction.

Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study (2018)
Journal Article
Ledwoch, K., Dancer, S., Otter, J., Kerr, K., Roposte, D., Rushton, L., Weiser, R., Mahenthiralingam, E., Muir, D., & Maillard, J. (2018). Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2018.06.028

Background Wet biofilms associated with medical devices have been widely studied and their link with healthcare-associated infections (HCAIs) is well recognized. Little attention has been paid to the presence of dry biofilms on environmental surface... Read More about Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study.

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring (2018)
Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., Howie, A. F., Rae, M. T., Van Soom, A., Li, R., Li, D., Zhang, H., & Vanhaecke, L. (2018). Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), Article e0201420. https://doi.org/10.1371/journal.pone.0201420

Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results requires normalisation due to an animal’s changing hydration. Correction of urinar... Read More about Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring.

Protracted diagnosis of ACNES: a costly exercise (2018)
Journal Article
Dancer, S. J., Macpherson, S. G., & de Beaux, A. C. (2018). Protracted diagnosis of ACNES: a costly exercise. Journal of Surgical Case Reports, 2018(9), 1-3. https://doi.org/10.1093/jscr/rjy230

This case report summarizes the course of events leading to diagnosis and eventual repair of anterior cutaneous nerve entrapment syndrome (ACNES) in a 58-year-old female. The time period elapsing from initial symptoms to final operative repair was 9... Read More about Protracted diagnosis of ACNES: a costly exercise.

Researching skills development: students as partners in this process (2018)
Journal Article
Campbell Casey, S., MacCallum, J., Robertson, L., & Strachan, L. (2018). Researching skills development: students as partners in this process. New Directions in the Teaching of Physical Sciences, 13(1), https://doi.org/10.29311/ndtps.v0i13.2881

Many employers report that newly qualified graduates lack key skills necessary for success in the workplace. Although variable, many lack general ‘transferable’ or ‘soft’ skills including communication and teamworking. Staff at Edinburgh Napier Unive... Read More about Researching skills development: students as partners in this process.

An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions (2019)
Journal Article
Smith, K., Muggeridge, D. J., Easton, C., & Ross, M. D. (2019). An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions. European Journal of Applied Physiology, 119(3), 723-733. https://doi.org/10.1007/s00421-018-04063-9

Purpose: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions. However, the ergogenic effects of dietary NO3- on intermittent exercise performance in hot conditions has... Read More about An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions.

Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry (2018)
Journal Article
Dancer, S. J., & Kramer, A. (2019). Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry. Journal of Hospital Infection, 103(1), e1-e8. https://doi.org/10.1016/j.jhin.2018.12.015

Background Now that cleaning and decontamination are recognised as integral to infection control, it is timely to examine the process in more detail. This is because cleaning practices vary widely within healthcare districts and it is likely that bo... Read More about Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry.