Skip to main content

Research Repository

Advanced Search

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men

Ross, Mark Daniel; Malone, Eva M; Simpson, Richard; Cranston, Islay; Ingram, Lesley; Wright, Graham P; Chambers, George; Florida-James, Geraint D

Authors

Mark Daniel Ross

Richard Simpson

Islay Cranston



Abstract

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating angiogenic cells (CACs) that are known to decline with age. However, the relationship between cardiorespiratory fitness (CRF) and age related changes in frequency of CACs, as well as the exercise-induced responsiveness of CACs in older individuals has not yet been determined. One hundred and seven healthy male volunteers, aged 18-75 years, participated in the study 1. CRF was estimated using submaximal cycling ergometer test. Circulating endothelial progenitor cells (EPCs), angiogenic T-cells (TANG) and their CXCR4 cell surface receptor expression were enumerated by flow cytometry using peripheral blood samples obtained under resting conditions prior to the exercise test. Study 2 recruited 17 healthy males (8 young, 18-25yrs; 9 older, 60-75yrs) and these participants undertook a 30-minute cycling exercise bout at 70% V ̇O2max, with CACs enumerated pre- and immediately post-exercise. Age was inversely associated with both CD34+ progenitor cells (r2=-0.140, p=0.000) and TANG (r2=-0.176, p=0.000) cells, as well as CXCR4-expressing CACs (CD34+, r2=-0.167, p=0.000; EPCs: r2=-0.098, p=0.001; TANG, r2=-0.053, p=0.015). However, after correcting for age, CRF had no relationship with either CAC subset. In addition, older individuals displayed attenuated exercise-induced increases in CD34+ progenitor cells, TANG, CD4+ TANG, and CD8+CXCR4+ TANG cells. Older men display lower CAC levels, which may contribute to increased CVD risk, and older adults display an impaired exercise-induced responsiveness of these cells.

Citation

Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., Chambers, G., & Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Journal Article Type Article
Acceptance Date Nov 14, 2017
Online Publication Date Nov 22, 2017
Publication Date 2018-03
Deposit Date Nov 23, 2017
Publicly Available Date Nov 23, 2018
Journal American Journal of Physiology - Heart and Circulatory Physiology
Print ISSN 0363-6135
Electronic ISSN 1522-1539
Publisher American Physiological Society
Peer Reviewed Peer Reviewed
Volume 314
Issue 3
Pages 392-402
DOI https://doi.org/10.1152/ajpheart.00592.2017
Keywords age, fitness, exercise, Progenitor cells, angiogenesis
Public URL http://researchrepository.napier.ac.uk/Output/1013430
Contract Date Nov 23, 2017

Files

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (1.8 Mb)
PDF









Related Outputs



You might also like



Downloadable Citations