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Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions (2024)
Journal Article
Neri, I., MacCallum, J., Di Lorenzo, R., Russo, G., Lynen, F., & Grumetto, L. (2024). Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions. Science of the Total Environment, 917, Article 170461. https://doi.org/10.1016/j.scitotenv.2024.170461

Five parabens (PBs) i.e., Methylparaben (MP), Ethylparaben (EP), Isopropylparaben (iPrP), Isobutylparaben (iBuP), Benzylparaben (BzP), and their parent compound i.e., para–hydroxy Benzoic Acid (pHBA), were studied both in vitro and in silico. Specifi... Read More about Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions.

From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring? (2023)
Presentation / Conference
Russo, G. (2023, September). From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?. Presented at 10th IAPC Meeting, Belgrade, Serbia

Biomimetic chromatography encompasses a range of analytical approaches aimed at mimicking the asset of biological membranes including – but not limited to – micellar liquid chromatography (MLC), immobilized artificial membranes (IAM) and immobilize... Read More about From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?.

High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC (2023)
Journal Article
Russo, G., Kajtazi, A., Vallaro, M., Surmont, P., Ermondi, G., Anderson, S., …Lynen, F. (2023). High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC. Journal of Pharmaceutical and Biomedical Analysis, 235, Article 115604. https://doi.org/10.1016/j.jpba.2023.115604

The charge state of a molecule is the single most prominent attribute ruling out its interactions with the surrounding environment. In a previous study, the retention of acids on the new Celeris™ Arginine (ARG) column was found to b... Read More about High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC.

Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction (2023)
Journal Article
Kajtazi, A., Russo, G., Wicht, K., Eghbali, H., & Lynen, F. (2023). Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction. Chemosphere, 337, Article 139361. https://doi.org/10.1016/j.chemosphere.2023.139361

Implementing effective environmental management strategies requires a comprehensive understanding of the chemical composition of environmental pollutants, particularly in complex mixtures. Utilizing innovative analytical techniques, such as high-reso... Read More about Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction.

The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption (2023)
Presentation / Conference
Dillon, A., Orzek, D., MacCallum, J., & Russo, G. (2023, June). The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption. Poster presented at HPLC 2023

Nowadays immobilized artificial membranes (IAM) are commonly used for modelling drug transport through biological lipid layers. In most published studies a compound’s lipophilicity measurements are performed in isocratic conditions where a low pe... Read More about The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption.

Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors (2022)
Journal Article
Russo, G., Piccolo, M., Neri, I., Ferraro, M. G., Santamaria, R., & Grumetto, L. (2023). Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors. Chemosphere, 313, Article 137569. https://doi.org/10.1016/j.chemosphere.2022.137569

Endocrine disruptors are chemicals widely used worldwide by industries in a variety of applications. Routinely exposure to these chemicals, even if at low doses, can cause damage effects on human health. In the present study, we evaluated toxic effec... Read More about Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors.

Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients (2022)
Journal Article
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., …Vitale, M. (2023). Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients. Environmental Pollution, 316, Article 120478. https://doi.org/10.1016/j.envpol.2022.120478

Bisphenol A (BPA) is a widespread thyroid disruptor, but evidence about an association with thyroid cancer is weak. Excess body weight is a risk factor for thyroid cancer and affects activity of endocrine disruptors. Aim of the study was to investiga... Read More about Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients.

Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers (2022)
Journal Article
Di Lorenzo, R., Neri, I., Russo, G., Laneri, S., & Grumetto, L. (2022). Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers. Cosmetics, 9(5), Article 102. https://doi.org/10.3390/cosmetics9050102

A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also... Read More about Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers.

Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography (2022)
Journal Article
Neri, I., Laneri, S., Di Lorenzo, R., Dini, I., Russo, G., & Grumetto, L. (2022). Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography. Molecules, 27(13), Article 4263. https://doi.org/10.3390/molecules27134263

Parabens (PBs) are used as preservatives to extend the shelf life of various foodstuffs, and pharmaceutical and cosmetic preparations. In this work, the membrane barrier passage potential of a subset of seven parabens, i.e., methyl-, ethyl-, propyl-... Read More about Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography.

Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy (2022)
Journal Article
Russo, G., Laneri, S., Di Lorenzo, R., Neri, I., Dini, I., Ciampaglia, R., & Grumetto, L. (2022). Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy. Molecules, 27(13), Article 3990. https://doi.org/10.3390/molecules27133990

The concentration levels of thirteen organic pollutants and selected heavy metals were investigated in 40 plastics bottled and tap water samples. Some of the selected contaminants have an ascertained or suspected endocrine disrupting activity, such a... Read More about Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy.

De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater (2022)
Presentation / Conference
Kajtazi, G., Wicht, K., Russo, G., Eghbali, H., & Lynen, F. (2022, May). De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater. Poster presented at 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium

Micropollutants, such as pharmaceuticals, industrial chemicals, steroid hormones, etc. are defined as anthropogenic chemicals and can be found in water. It is seen as a serious threat, not just to aquatic life but also to humans, which requires the a... Read More about De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater.

Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation (2022)
Presentation / Conference
Lynen, F., Russo, G., & Gallikova, J. (2022, May). Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation. Paper presented at 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium

In this work fused deposition modeling (FDM) based 3D-printing is used for the manufacturing of cartridges for solid phase extraction. The novelty of the approach is that the 3D-printing is used for the simultaneous printing of the porous retentive b... Read More about Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation.

Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules (2022)
Journal Article
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., …Vitale, M. (2022). Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules. Endocrine abstracts, 81, Article P394. https://doi.org/10.1530/endoabs.81.p394

Introduction: The plasticizer Bisphenol A (BPA) is an endocrine disruptor with thyroid interfering activity. Obesity is a recognized risk factor for thyroid cancer. A recent study showed that subjects with BMI ≥ 25 are more prone to BPA-related thyro... Read More about Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules.

cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity? (2021)
Journal Article
Grumetto, L., & Russo, G. (2021). cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?. ADMET and DMPK, 9(4), 267-281. https://doi.org/10.5599/admet.1034

56 compounds, whose log BB values were known from the scientific literature, were considered and their phospholipophilicity values were calculated in silico. These values, along with either experimentally determined or calculated lipophilicity values... Read More about cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?.

Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis (2021)
Journal Article
Russo, G., Vallaro, M., Cappelli, L., Anderson, S., Ermondi, G., & Caron, G. (2021). Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis. Journal of Chromatography A, 1651, Article 462316. https://doi.org/10.1016/j.chroma.2021.462316

CelerisTM Arginine (ARG) is a mixed-mode stationary phase recently released on the market. To characterize its analytical behavior, the retention factors of a pool (n=100, of which 36 neutrals, 26 acids and 38 bases) of pharmaceutically relevant comp... Read More about Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis.

Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells (2021)
Journal Article
Russo, G., Iaccarino, G., Piccolo, M., Ferraro, M. G., Vecchione, R., Grumetto, L., …Santamaria, R. (2021). Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells. European Journal of Pharmaceutical Sciences, 162, Article 105825. https://doi.org/10.1016/j.ejps.2021.105825

A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form and termed rMnSOD. As compared to other SODs, this isoform exhibits a dramatically improved cellular uptake and an int... Read More about Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells.

The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy (2021)
Journal Article
Russo, G., Laneri, S., Di Lorenzo, R., Ferrara, L., & Grumetto, L. (2021). The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy. Water Environment Research, 93(10), 1944-1958. https://doi.org/10.1002/wer.1566

Endocrine disrupting chemicals (EDCs) are agents able to exert perturbation toward the endocrine system via a broad array of signalling pathways. Some EDCs are released into the environment as a result of antropogenic activities. Analytical surveilla... Read More about The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy.

Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment (2021)
Journal Article
Akhbarizadeh, R., Russo, G., Rossi, S., Golianova, K., Moore, F., Guida, M., …Grumetto, L. (2021). Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment. Marine Pollution Bulletin, 166, Article 112241. https://doi.org/10.1016/j.marpolbul.2021.112241

The occurrence of endocrine disrupting chemicals (EDCs) has been determined in two widely consumed fish species from Persian Gulf i.e., Epinephelus coioides and Platycephalus indicus by applying a validated analytical for the simultaneous detection o... Read More about Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment.

Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development (2020)
Journal Article
Russo, G., Grumetto, L., Baert, M., & Lynen, F. (2021). Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development. Analytica Chimica Acta, 1142, 157-168. https://doi.org/10.1016/j.aca.2020.11.003

A comprehensive two-dimensional liquid chromatography-based biomimetic platform (LCxLC) has been developed and validated for drug diffusion studies. Human serum albumin (HSA) and immobilized artificial membrane (IAM) were thereby used in the first (1... Read More about Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development.

Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity (2020)
Journal Article
Russo, G., Ermondi, G., Caron, G., Verzele, D., & Lynen, F. (2021). Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity. European Journal of Pharmaceutical Sciences, 156, 105585. https://doi.org/10.1016/j.ejps.2020.105585

State of the art: Sphingomyelin (SPH) is a type of sphingolipid found in animal nerve tissues, especially in the membranous myelin sheath that surrounds some nerve cell axons. Because of its characteristics, SPH stationary phase represents an ideal t... Read More about Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity.

Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution (2019)
Journal Article
Russo, G., Grumetto, L., Mita, D. G., Rossi, S., Guida, M., Di Marco Pisciottano, I., & Gallo, P. (2019). Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution. Desalination and Water Treatment, 170, 158-167. https://doi.org/10.5004/dwt.2019.24651

The removal of 17alfa-ethinylestradiol (EE2) from synthetic aqueous solutions under adsorption process and enzyme catalysis mediated by immobilized laccase from Trametes versicolor was studied. Both processes were carried... Read More about Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution.

Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection (2019)
Journal Article
Del Prete, S., Marasco, D., Del Prete, A., Meloni, M., Capaldi, R., Grumetto, L., & Russo, G. (2019). Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection. Archives of Case Reports, 3(1), 50-53. https://doi.org/10.29328/journal.acr.1001024

Purpose: This work is aimed at demonstrating that scraping cytology and scanning electron microscopy can successfully assist in the diagnosis of nontuberculous mycobacteria infection. For this purpose, we report the use of both these techniques in th... Read More about Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection.

Are Canned Beverages Industries Progressively Switching to Bisphenol AF? (2019)
Journal Article
Russo, G., Varriale, F., Barbato, F., & Grumetto, L. (2019). Are Canned Beverages Industries Progressively Switching to Bisphenol AF?. Journal of Food Science, 84(11), 3303-3311. https://doi.org/10.1111/1750-3841.14833

Seven bisphenols, endocrine‐disruptor chemicals, were analytically determined for risk assessment in 52 large‐consumption beverages collected from the Italian market. The analytes under examination were bisphenol A, bisphenol F, bisphenol E, bispheno... Read More about Are Canned Beverages Industries Progressively Switching to Bisphenol AF?.

Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe (2019)
Journal Article
Russo, G., Barbato, F., Mita, D. G., & Grumetto, L. (2019). Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe. Food and Chemical Toxicology, 131, https://doi.org/10.1016/j.fct.2019.110575

Bisphenol A and its analogues belong to the class of endocrine disrupting chemicals, massively employed by industries to produce polycarbonate and epoxy resins, designed to be in direct contact with foodstuffs. Their leaching from the canned packagin... Read More about Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe.

Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography (2019)
Journal Article
Russo, G., Barbato, F., Grumetto, L., Philippe, L., Lynen, F., & Goetz, G. H. (2019). Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography. International Journal of Pharmaceutics, 560, 294-305. https://doi.org/10.1016/j.ijpharm.2019.02.008

The present work proposes a novel application of EPSA (not an acronym but found to be referred to by many as Exposed Polar Surface Area), a supercritical fluid chromatography (SFC) polarity readout for assisting in the prediction of the extent of dru... Read More about Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.

Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions (2019)
Journal Article
Grumetto, L., Barbato, F., & Russo, G. (2019). Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions. Environmental Toxicology and Pharmacology, 68, 148-154. https://doi.org/10.1016/j.etap.2019.02.008

The interactions between human serum albumin (HSA) and α1- acid glycoprotein (AGP), the main plasma proteins binding drugs/xenobiotics, and some endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA) and some of its structural analogues, bi... Read More about Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions.

Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method (2018)
Journal Article
Russo, G., Barbato, F., Mita, D. G., & Grumetto, L. (2019). Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method. Biomedical Chromatography, 33(3), e4427. https://doi.org/10.1002/bmc.4427

A quick and inexpensive validated method, based on sample treatment by liquid–liquid microextraction followed by liquid chromatography (LC) coupled with ultraviolet tandem fluorescence detection is proposed for the determination of 15 multiclass poll... Read More about Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method.

Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules (2018)
Journal Article
Marotta, V., Russo, G., Gambardella, C., Grasso, M., La Sala, D., Chiofalo, M. G., …Grumetto, L. (2019). Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules. Chemosphere, 218, 885-894. https://doi.org/10.1016/j.chemosphere.2018.11.084

Pollutants represent potential threats to the human health, being ubiquitous in the environment and exerting toxicity even at low doses. This study aims at investigating the role of fifteen multiclass organic pollutants, assumed as markers of environ... Read More about Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules.

Cytotoxicity of seven bisphenol analogues compared to bisphenol A and relationships with membrane affinity data (2018)
Journal Article
Russo, G., Capuozzo, A., Barbato, F., Irace, C., Santamaria, R., & Grumetto, L. (2018). Cytotoxicity of seven bisphenol analogues compared to bisphenol A and relationships with membrane affinity data. Chemosphere, 201, 432-440. https://doi.org/10.1016/j.chemosphere.2018.03.014

Bisphenol A (BPA) is a chemical used in numerous industrial applications. Due to its well ascertained toxicity as endocrine disruptor, industries have started to replace it with other bisphenols whose alleged greater safety is scarcely supported by l... Read More about Cytotoxicity of seven bisphenol analogues compared to bisphenol A and relationships with membrane affinity data.

Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry (2018)
Journal Article
Russo, G., Grumetto, L., Szucs, R., Barbato, F., & Lynen, F. (2018). Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry. European Journal of Pharmaceutics and Biopharmaceutics, 127, 72-84. https://doi.org/10.1016/j.ejpb.2018.02.004

The Blood-Brain Barrier (BBB) plays an essential role in protecting the brain tissues against possible injurious substances. In the present work, 79 neutral, basic, acidic and amphoteric structurally unrelated analytes were considered and their chrom... Read More about Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry.

Bisphenol A and Bisphenol S release in milk under household conditions from baby bottles marketed in Italy (2017)
Journal Article
Russo, G., Barbato, F., Cardone, E., Fattore, M., Albrizio, S., & Grumetto, L. (2018). Bisphenol A and Bisphenol S release in milk under household conditions from baby bottles marketed in Italy. Journal of Environmental Science and Health, Part B, 53(2), 116-120. https://doi.org/10.1080/03601234.2017.1388662

A simple and sensitive validated analytical method based on liquid chromatography coupled to tandem fluorescence (FD) and ultraviolet (UV) spectrophotometry was applied to monitor the presence of bisphenol A and bisphenol S in plastic baby bottles ma... Read More about Bisphenol A and Bisphenol S release in milk under household conditions from baby bottles marketed in Italy.

Plasma p-cresol lowering effect of sevelamer in non-dialysis CKD patients: evidence from a randomized controlled trial (2017)
Journal Article
Riccio, E., Sabbatini, M., Bruzzese, D., Grumetto, L., Marchetiello, C., Amicone, M., …Pisani, A. (2018). Plasma p-cresol lowering effect of sevelamer in non-dialysis CKD patients: evidence from a randomized controlled trial. Clinical and Experimental Nephrology, 22(3), 529-538. https://doi.org/10.1007/s10157-017-1504-8

Background The accumulation of p-cresol, a metabolic product of aromatic amino acids generated by intestinal microbiome, increases the cardiovascular risk in chronic kidney disease (CKD) patients. Therefore, therapeutic strategies to reduce plasma p... Read More about Plasma p-cresol lowering effect of sevelamer in non-dialysis CKD patients: evidence from a randomized controlled trial.

Cholesterol affects the interaction between an ionic liquid and phospholipid vesicles. A study by differential scanning calorimetry and nanoplasmonic sensing (2017)
Journal Article
Russo, G., Witos, J., Rantamäki, A. H., & Wiedmer, S. K. (2017). Cholesterol affects the interaction between an ionic liquid and phospholipid vesicles. A study by differential scanning calorimetry and nanoplasmonic sensing. BBA - Biomembranes, 1859(12), 2361-2372. https://doi.org/10.1016/j.bbamem.2017.09.011

The present work aims at studying the interactions between cholesterol-rich phosphatidylcholine-based lipid vesicles and trioctylmethylphosphonium acetate ([P8881][OAc]), a biomass dissolving ionic liquid (IL). The effect of cholesterol was assayed b... Read More about Cholesterol affects the interaction between an ionic liquid and phospholipid vesicles. A study by differential scanning calorimetry and nanoplasmonic sensing.

Improvement of Retinal Function after Administration of an Ophthalmic Gel Containing a New Recombinant form of Superoxide Dismutase (2017)
Journal Article
Grumetto, L., Prete, A. D., Russo, G., Borrelli, A., Del Prete, S., & Mancini, A. (2017). Improvement of Retinal Function after Administration of an Ophthalmic Gel Containing a New Recombinant form of Superoxide Dismutase. IL Journal of Clinical Case Reports, 1(1), 1-5

Two cases of severe age-related eye maculopathy diagnosed in a 73-year-old and a 53-year-old patient are presented. A gel formulation containing a new recombinant form of manganese superoxide dismutase (rMnSOD) was administered to both patients, as c... Read More about Improvement of Retinal Function after Administration of an Ophthalmic Gel Containing a New Recombinant form of Superoxide Dismutase.

Monitoring of bisphenol A and bisphenol S in thermal paper receipts from the Italian market and estimated transdermal human intake: A pilot study (2017)
Journal Article
Russo, G., Barbato, F., & Grumetto, L. (2017). Monitoring of bisphenol A and bisphenol S in thermal paper receipts from the Italian market and estimated transdermal human intake: A pilot study. Science of the Total Environment, 599-600, 68-75. https://doi.org/10.1016/j.scitotenv.2017.04.192

Bisphenol A (BPA), a synthetic xenoestrogen widely used in various industrial fields, can be present, in its un-reacted form, as an additive in thermal paper. BPA is virtually ubiquitous in industrialized societies and humans are exposed to this chem... Read More about Monitoring of bisphenol A and bisphenol S in thermal paper receipts from the Italian market and estimated transdermal human intake: A pilot study.

Determination of in Vitro and in Silico Indexes for the Modeling of Blood–Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography (2017)
Journal Article
Russo, G., Grumetto, L., Szucs, R., Barbato, F., & Lynen, F. (2017). Determination of in Vitro and in Silico Indexes for the Modeling of Blood–Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography. Journal of Medicinal Chemistry, 60(9), 3739-3754. https://doi.org/10.1021/acs.jmedchem.6b01811

In the present work, 79 structurally unrelated analytes were taken into account and their chromatographic retention coefficients, measured by immobilized artificial membrane liquid chromatography (IAM-LC) and by micellar liquid chromatography (MLC) e... Read More about Determination of in Vitro and in Silico Indexes for the Modeling of Blood–Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography.

Unraveling Interactions between Ionic Liquids and Phospholipid Vesicles Using Nanoplasmonic Sensing (2017)
Journal Article
Witos, J., Russo, G., Ruokonen, S., & Wiedmer, S. K. (2017). Unraveling Interactions between Ionic Liquids and Phospholipid Vesicles Using Nanoplasmonic Sensing. Langmuir, 33(4), 1066-1076. https://doi.org/10.1021/acs.langmuir.6b04359

Owing to their unique properties and unlimited structural combinations, the ubiquitous use of ionic liquids (ILs) is steadily increasing. The objective of the present work is to shed light onto the effects of amidinium- and phosphonium-based ILs on p... Read More about Unraveling Interactions between Ionic Liquids and Phospholipid Vesicles Using Nanoplasmonic Sensing.

Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors (2016)
Journal Article
Russo, G., Grumetto, L., Barbato, F., Vistoli, G., & Pedretti, A. (2017). Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors. European Journal of Pharmaceutical Sciences, 99, 173-184. https://doi.org/10.1016/j.ejps.2016.11.026

The present study proposes a method for an in silico calculation of phospholipophilicity. Phospholipophilicity is intended as the measure of analyte affinity for phospholipids; it is currently assessed by HPLC measures of analyte retention on phospha... Read More about Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors.

Immobilized Artificial Membrane HPLC Derived Parameters vs PAMPA-BBB Data in Estimating in Situ Measured Blood–Brain Barrier Permeation of Drugs (2016)
Journal Article
Grumetto, L., Russo, G., & Barbato, F. (2016). Immobilized Artificial Membrane HPLC Derived Parameters vs PAMPA-BBB Data in Estimating in Situ Measured Blood–Brain Barrier Permeation of Drugs. Molecular Pharmaceutics, 13(8), 2808-2816. https://doi.org/10.1021/acs.molpharmaceut.6b00397

The affinity indexes for phospholipids (log kWIAM) for 42 compounds were measured by high performance liquid chromatography (HPLC) on two different phospholipid-based stationary phases (immobilized artificial membrane, IAM), i.e., IAM.PC.MG and IAM.P... Read More about Immobilized Artificial Membrane HPLC Derived Parameters vs PAMPA-BBB Data in Estimating in Situ Measured Blood–Brain Barrier Permeation of Drugs.

Development and Validation of a LC-FD Method for the Simultaneous Determination of Eight Bisphenols in Soft Drinks (2016)
Journal Article
Russo, G., Barbato, F., & Grumetto, L. (2016). Development and Validation of a LC-FD Method for the Simultaneous Determination of Eight Bisphenols in Soft Drinks. Food Analytical Methods, 9(10), 2732-2740. https://doi.org/10.1007/s12161-016-0458-x

Bisphenol A (BPA) is a chemical widely used as a monomer in the production of polymers of plastics. It acts as an endocrine-disrupting agent and thus its contaminations of food and beverage should be carefully monitored in order to assess consumers’... Read More about Development and Validation of a LC-FD Method for the Simultaneous Determination of Eight Bisphenols in Soft Drinks.

Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption (2016)
Journal Article
Grumetto, L., Russo, G., & Barbato, F. (2016). Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption. International Journal of Pharmaceutics, 500(1-2), 275-290. https://doi.org/10.1016/j.ijpharm.2016.01.019

The relationships between data of passage through Caco-2 cultured cell lines (log Pₐₚₚ), taken from the literature, for 38 structurally unrelated compounds and both n-octanol lipophilicity parameters (log Pᴺ and log D⁷.⁴) and phospholipid affinity in... Read More about Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption.

A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules (2015)
Journal Article
Russo, G., Barbato, F., & Grumetto, L. (2016). A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules. Journal of Pharmaceutical and Biomedical Analysis, 117, 436-445. https://doi.org/10.1016/j.jpba.2015.09.027

A simple LC/UV method for the simultaneous identification and quantification of Fluoxetine, Tiratricol, Benfluorex and Pseudoephedrine in slimming formulation is proposed. The method demonstrated effective in the analyses of herbal mixtures marketed... Read More about A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules.

Monitoring of bisphenols in canned tuna from Italian markets (2015)
Journal Article
Fattore, M., Russo, G., Barbato, F., Grumetto, L., & Albrizio, S. (2015). Monitoring of bisphenols in canned tuna from Italian markets. Food and Chemical Toxicology, 83, 68-75. https://doi.org/10.1016/j.fct.2015.05.010

Monitoring of food contamination from bisphenols is a necessary process for the consumers' risk assessment. A method for the quali-quantitative analysis of Bisphenol A (BPA), Bisphenol B (BPB), Bisphenol A Diglycidyl Ether (BADGE), and Bisphenol F Di... Read More about Monitoring of bisphenols in canned tuna from Italian markets.

Relationships between human intestinal absorption and polar interactions drug/phospholipids estimated by IAM–HPLC (2015)
Journal Article
Grumetto, L., Russo, G., & Barbato, F. (2015). Relationships between human intestinal absorption and polar interactions drug/phospholipids estimated by IAM–HPLC. International Journal of Pharmaceutics, 489(1-2), 186-194. https://doi.org/10.1016/j.ijpharm.2015.04.062

Phospholipid affinity indexes (log 𝑘 ᴵᴬᴹ/W) for 15 structurally non-related basic, acidic, ampholytic, and neutral drugs were measured by HPLC on two different phospholipid stationary phases (immobilized artificial membrane – IAM). According to a me... Read More about Relationships between human intestinal absorption and polar interactions drug/phospholipids estimated by IAM–HPLC.

Dioxin-like PCB levels in maternal and umbilical cord sera of people living near dump sites in southern Italy: a pilot study of biomonitoring (2015)
Journal Article
Grumetto, L., Ortosecco, G., Russo, G., Guida, M., Ferranti, P., Nasi, A., & Barbato, F. (2015). Dioxin-like PCB levels in maternal and umbilical cord sera of people living near dump sites in southern Italy: a pilot study of biomonitoring. Environmental Monitoring and Assessment, 187(3), https://doi.org/10.1007/s10661-015-4267-2

The “Triangle of Death” is an area of southern Italy highly polluted due to the presence of numerous illegal waste sites. To assess whether environmental contamination could produce an increased intake of harmful chemicals, we determined the serum le... Read More about Dioxin-like PCB levels in maternal and umbilical cord sera of people living near dump sites in southern Italy: a pilot study of biomonitoring.

Indexes of polar interactions between ionizable drugs and membrane phospholipids measured by IAM–HPLC: Their relationships with data of Blood–Brain Barrier passage (2014)
Journal Article
Grumetto, L., Russo, G., & Barbato, F. (2014). Indexes of polar interactions between ionizable drugs and membrane phospholipids measured by IAM–HPLC: Their relationships with data of Blood–Brain Barrier passage. European Journal of Pharmaceutical Sciences, 65, 139-146. https://doi.org/10.1016/j.ejps.2014.09.015

Phospholipid affinity indexes (log k IAM/w) for 21 structurally non-related basic, acidic, ampholytic, and neutral drugs were measured by HPLC on two different phospholipid stationary phases (Immobilized Artificial Membrane – IAM). The differences b... Read More about Indexes of polar interactions between ionizable drugs and membrane phospholipids measured by IAM–HPLC: Their relationships with data of Blood–Brain Barrier passage.