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Dr Janis MacCallum's Outputs (19)

Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions (2024)
Journal Article
Neri, I., MacCallum, J., Di Lorenzo, R., Russo, G., Lynen, F., & Grumetto, L. (2024). Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions. Science of the Total Environment, 917, Article 170461. https://doi.org/10.1016/j.scitotenv.2024.170461

Five parabens (PBs) i.e., Methylparaben (MP), Ethylparaben (EP), Isopropylparaben (iPrP), Isobutylparaben (iBuP), Benzylparaben (BzP), and their parent compound i.e., para–hydroxy Benzoic Acid (pHBA), were studied both in vitro and in silico. Specifi... Read More about Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions.

Researching skills development: students as partners in this process (2018)
Journal Article
Campbell Casey, S., MacCallum, J., Robertson, L., & Strachan, L. (2018). Researching skills development: students as partners in this process. New Directions in the Teaching of Physical Sciences, 13(1), https://doi.org/10.29311/ndtps.v0i13.2881

Many employers report that newly qualified graduates lack key skills necessary for success in the workplace. Although variable, many lack general ‘transferable’ or ‘soft’ skills including communication and teamworking. Staff at Edinburgh Napier Unive... Read More about Researching skills development: students as partners in this process.

Enhancing skills development and reflective practise in students during their programme of study (2017)
Journal Article
MacCallum, J., & Campbell Casey, S. (2017). Enhancing skills development and reflective practise in students during their programme of study. New Directions in the Teaching of Physical Sciences, 12(12), https://doi.org/10.29311/ndtps.v0i12.2368

The transition to the workplace can be challenging for new graduates. At Edinburgh Napier our approach is to work proactively with students to prepare them for the world of work. Staff within the School of Applied Sciences have partnered with both in... Read More about Enhancing skills development and reflective practise in students during their programme of study.

Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion (2016)
Journal Article
Ramaswamy, S., McNeilly, A. S., Rae, M. T., Ramaswamy, S., Grace, C., Mattei, A. A., Siemienowicz, K., Brownlee, W., MacCallum, J., McNeilly, A. S., Duncan, W. C., & Rae, M. T. (2016). Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion. Scientific Reports, 6(1), Article 27408. https://doi.org/10.1038/srep27408

Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fetuses at d62 and d82 of gestation, and examined fetal (day 90 gestation) and... Read More about Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion.

Audio feedback: richer language but no measurable impact on student performance (2014)
Journal Article
Chalmers, C., MacCallum, J., Mowat, E., & Fulton, N. (2014). Audio feedback: richer language but no measurable impact on student performance. Practitioner Research in Higher Education, 8, 64-73

Audio feedback has been shown to be popular and well received by students. However, there is little published work to indicate how effective audio feedback is in improving student performance.
Sixty students from a first year science degree agreed... Read More about Audio feedback: richer language but no measurable impact on student performance.

The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS) (2013)
Journal Article
Franks, S., Rae, M. T., Grace, C., Hogg, K., Wilson, L. M., McHaffie, S. L., Ramaswamy, S., MacCallum, J., Connolly, F., McNeilly, A. S., & Duncan, C. (2013). The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS). PLOS ONE, 8(2), Article e56263. https://doi.org/10.1371/journal.pone.0056263

Using an ovine model of polycystic ovary syndrome (PCOS), (pregnant ewes injected with testosterone propionate (TP) (100 mg twice weekly) from day (d)62 to d102 of d147 gestation (maternal injection – MI-TP)), we previously reported female offspring... Read More about The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS).

Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation (2008)
Journal Article
Zhao, M., Brown, D. M., MacCallum, J., & Proudfoot, L. (2008). Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation. Parasite Immunology, 31(1), 50-56. https://doi.org/10.1111/j.1365-3024.2008.01073.x

The anti-inflammatory properties of parasitic helminths have been largely linked to their excretory-secretory (ES) products. Some studies have noted a lack of TNF-alpha production and limited recruitment of neutrophils into the lungs after Nippostron... Read More about Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation.

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure (2007)
Journal Article
Barlow, P. G., Brown, D. M., Donaldson, K., MacCallum, J., & Stone, V. (2008). Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24(3), 243-252. https://doi.org/10.1007/s10565-007-9033-y

Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiovascular disorders. The exact mechanism by which PM10 drives toxicity in the... Read More about Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure.

Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. (2005)
Journal Article
Barlow, P. G., Clouter-Baker, A., Donaldson, K., MacCallum, J., & Stone, V. (2005). Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and fibre toxicology, 2(1), 11-24. https://doi.org/10.1186/1743-8977-2-11

Background - Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanoparticles are considered a potential threat to the lungs and the mechanism of... Read More about Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages..

Ticks and Lyme Disease. (2004)
Journal Article
Chalmers, C., MacCallum, J., Brown, J., & Anderson, R. (2004). Ticks and Lyme Disease. Practice Nursing, 15,

Ticks are prevalent in parts of the UK during the summer months. Charlotte Chalmers, Janis MacCallum, Jane Brown and Ros Anderson discuss the associated diseases and recommend a method of removal.

Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration (2004)
Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005). Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.11.006

Objective:
To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a model previously reported to investigate complement activation by other respir... Read More about Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration.

Concentration of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours (2000)
Journal Article
MacCallum, J., Cummings, J., Dixon, J. M., & Miller, W. R. (2000). Concentration of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours. Nature, 82(10), 1629-1635. https://doi.org/10.1054/bjoc.2000.1120

Patients treated with tamoxifen (TAM) for primary breast cancer often manifest de novo or acquired resistance, possibly through changes in drug metabolism. Using solid-phase extraction methods and reversed-phase high-performance liquid chromatography... Read More about Concentration of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours.

Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers (1998)
Journal Article
Phillips, H., MacCallum, J., Burns, D., Cho-Chung, Y., & Miller, W. (1998). Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers. The Breast, 7(3), 139-142. https://doi.org/10.1016/s0960-9776%2898%2990024-8

There is evidence that the regulatory subunits (R) of cyclic AMP-dependent protein kinase A (PKA) are important in the biology of breast cancer and that mutations of both RIα and RIIβ, alter cellular behaviour. Consequently, a PCR-SSCP assay was esta... Read More about Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers.

Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues (1997)
Journal Article
MacCallum, J., Cummings, J., Dixon, J., & Miller, W. (1997). Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues. Journal of Chromatography B, 698(1-2), 269-275. https://doi.org/10.1016/S0378-4347%2897%2900286-7

A sensitive (200 ng/g) and selective reversed-phase high-performance liquid chromatography separation has been developed to determine the levels of tamoxifen, 4-hydroxytamoxifen (4-OH) and desmethyltamoxifen (DMT) in tumour tissue taken from patients... Read More about Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues.

Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy (1996)
Journal Article
MacCallum, J., Keen, J., Bartlett, J., Thompson, A., Dixon, J., & Miller, W. (1996). Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy. British Journal of Cancer, 74(3), 474-478. https://doi.org/10.1038/bjc.1996.385

Tumour was obtained from 37 patients with oestrogen receptor-positive breast cancer, before and during treatment with tamoxifen, and examined qualitatively and semi-qualitatively for mRNA of the three mammalian TGF-beta isoforms. Levels of TGF-beta i... Read More about Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy.

Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma (1996)
Journal Article
MacCallum, J., Cummings, J., Dixon, J., & Miller, W. (1996). Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma. Journal of Chromatography B, 678(2), 317-323. https://doi.org/10.1016/0378-4347%2895%2900530-7

Tamoxifen (TAM) is a triphenylethylene anti-oestrogen, commonly used in the treatment of breast cancer. Patients receiving tamoxifen therapy may experience both de novo and acquired resistance. As one of the mechanisms for this may be extensive perip... Read More about Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma.

Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization (1995)
Journal Article
MacCallum, J., Poulsom, R., Hanby, A., & Miller, W. (1995). Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization. The Breast, 4(4), 289-296. https://doi.org/10.1016/s0960-9776%2895%2980006-9

As transforming growth factor betas (TGFβs) are of potential importance in the natural history of breast cancer, it is desirable to develop assays which allow detection of the isoforms of TGFβ, at the level of mRNA and protein in clinical material. I... Read More about Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization.

Expression of transforming growth factor beta mRNA isoforms in human breast cancer (1994)
Journal Article
MacCallum, J., Bartlett, J., Thompson, A., Keen, J., Dixon, J., & Miller, W. (1994). Expression of transforming growth factor beta mRNA isoforms in human breast cancer. British Journal of Cancer, 69(6), 1006-1009. https://doi.org/10.1038/bjc.1994.197

Using an RNAse protection assay, expression of messenger RNA for isoforms of TGF-beta was determined in a series of breast cancers. Of 50 tumours, 45 (90%) expressed TGF-beta 1 mRNA, 39 (78%) expressed TGF-beta 2, and 47 (94%) expressed TGF-beta 3. P... Read More about Expression of transforming growth factor beta mRNA isoforms in human breast cancer.