Dr Graham Wright's Outputs (17)

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy (2019)
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., Barlow, P., & Stevens, C. (2019). The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), Article e0209665. https://doi.org/10.1371/journal.pone.0209665

The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively... Read More about The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

MS TCR Therapy (2018)
Patent
Wright, G., Stauss, H., & McGovern, J. MS TCR Therapy. United Kingdon

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., Chambers, G., & Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

Engineering Specificity and Function of Therapeutic Regulatory T Cells (2017)
Journal Article
McGovern, J. L., Wright, G. P., & Stauss, H. J. (2017). Engineering Specificity and Function of Therapeutic Regulatory T Cells. Frontiers in Immunology, 8, Article 1517. https://doi.org/10.3389/fimmu.2017.01517

Adoptive therapy with polyclonal regulatory T cells (Tregs) has shown efficacy in suppressing detrimental immune responses in experimental models of autoimmunity and transplantation. The lack of specificity is a potential limitation of Treg therapy,... Read More about Engineering Specificity and Function of Therapeutic Regulatory T Cells.

Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study (2017)
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Imber, C., Sharma, D., Malago, M., Fuller, B. J., & Davidson, B. R. (2017). Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study. HPB, 19(9), 757-767. https://doi.org/10.1016/j.hpb.2017.05.005

Background
Ischaemia Reperfusion (IR) injury is a major cause of morbidity, mortality and graft loss following Orthotopic Liver Transplantation (OLT). Utilising marginal grafts, which are more susceptible to IR injury, makes this a key research goal... Read More about Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study.

A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation (2016)
Journal Article
Robertson, F. P., Magill, L. J., Wright, G. P., Fuller, B., & Davidson, B. R. (2016). A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation. Transplant International, 29(11), 1147-1154. https://doi.org/10.1111/tri.12849

Ischaemic preconditioning (IPC) is a strategy to reduce ischaemia–reperfusion (IR) injury. Its benefit in human liver transplantation is unclear. The aim of this study was to analyse the current evidence for donor IPC in liver transplantation. System... Read More about A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation.

Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial) (2016)
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Fuller, B., & Davidson, B. R. (2016). Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial). Transplantation Research, 5(1), https://doi.org/10.1186/s13737-016-0033-4

Ischaemic reperfusion (IR) injury is a major cause of graft loss, morbidity and mortality following orthotopic liver transplantation (OLT). Demand for liver transplantation has resulted in increasing use of marginal grafts that are more prone to IR i... Read More about Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial).

Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo (2013)
Journal Article
Xue, S., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., …Stauss, H. J. (2013). Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology, 2(1), Article e22590. https://doi.org/10.4161/onci.22590

In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma, nasopharyngeal carcinoma and medulloblastoma, respectively. Retroviral... Read More about Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo.

CD3 limits the efficacy of TCR gene therapy in vivo (2011)
Journal Article
Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., …Stauss, H. J. (2011). CD3 limits the efficacy of TCR gene therapy in vivo. Blood, 118(13), 3528-3537. https://doi.org/10.1182/blood-2011-04-346338

The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR
/ heterodimer. We tested whether endogenous CD3 chains are rate-limiting for TCR expression and antigen-specific T-cell fu... Read More about CD3 limits the efficacy of TCR gene therapy in vivo.

Therapeutic potential of Tregs to treat rheumatoid arthritis (2011)
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there ar... Read More about Therapeutic potential of Tregs to treat rheumatoid arthritis.

Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies (2011)
Journal Article
Kinloch, A. J., Ng, K., & Wright, G. P. (2011). Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies. Recent patents on inflammation & allergy drug discovery, 5(2), 108-127. https://doi.org/10.2174/187221311795399246

Rheumatoid arthritis (RA), although widely considered to be the most commonly occurring autoimmune disease, has only truly been substantiated as a distinct autoimmune disease very recently. The lack of understanding of the specific autoimmune system/... Read More about Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies.

Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity (2011)
Journal Article
Wright, G. P., Ehrenstein, M. R., & Stauss, H. J. (2011). Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity. Expert Review of Clinical Immunology, 7(2), 213-225. https://doi.org/10.1586/eci.10.96

Tregs have shown considerable potential in treating preclinical models of autoimmunity. These studies have highlighted the importance of Treg antigen (Ag) specificity. Translation of these promising results to the clinic will require a robust method... Read More about Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity.

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells (2011)
Journal Article
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8), 4967-4972. https://doi.org/10.4049/jimmunol.1003021

The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in the removal of apoptotic cells, we investigated whether the immune modulator... Read More about Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells.

Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation (2010)
Book Chapter
Ghorashian, S., Wright, G., Thomas, S., Hart, D. P., King, J., Voisine, C., Pospori, C., Perro, M., Cesco-Gaspere, M., Holler, A., Gao, L., Xue, S.-A., Morris, E. C., Chakraverty, R., & Stuass, H. J. (2010). Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation. In Y. Reisner, & M. F. Martelli (Eds.), Bone Marrow Transplantation Across Major Genetic Barriers (373-395). World Scientific. https://doi.org/10.1142/9789814271271_0016

Allogeneic hematopoietic stem cell transplantation (HSCT) is carried out to correct genetic disorders of the hematopoietic system, as well as to treat hematopoietic malignancies. Adoptive Tcell therapy has great potential as an adjunct to this treatm... Read More about Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation.

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis (2009)
Journal Article
Wright, G. P., Notley, C. A., Xue, S. A., Bendle, G. M., Holler, A., Schumacher, T. N., Ehrenstein, M. R., & Stauss, H. J. (2009). Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences, 106(45), 19078-19083. https://doi.org/10.1073/pnas.0907396106

Regulatory T cells (Tregs) can suppress a wide range of immune cells, making them an ideal candidate for the treatment of autoimmunity. The potential clinical translation of targeted therapy with antigen-specific Tregs is hampered by the difficulties... Read More about Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis.

Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy (2007)
Journal Article
Stauss, H. J., Cesco-Gaspere, M., Thomas, S., Hart, D. P., Xue, S., Holler, A., …Morris, E. C. (2007). Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy. Molecular Therapy, 15(10), 1744-1750. https://doi.org/10.1038/sj.mt.6300216

Adoptive transfer of antigen-specific T lymphocytes is an effective form of immunotherapy for persistent virus infections and cancer. A major limitation of adoptive therapy is the inability to isolate antigen-specific T lymphocytes reproducibly. The... Read More about Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy.

WT1-specific T cell receptor gene therapy: Improving TCR function in transduced T cells (2007)
Journal Article
Stauss, H. J., Thomas, S., Cesco-Gaspere, M., Hart, D. P., Xue, S., Holler, A., King, J., Wright, G., Perro, M., Pospori, C., & Morris, E. (2008). WT1-specific T cell receptor gene therapy: Improving TCR function in transduced T cells. Blood Cells, Molecules and Diseases, 40(1), 113-116. https://doi.org/10.1016/j.bcmd.2007.06.018

Adoptive transfer of antigen-specific T lymphocytes is an attractive form of immunotherapy for haematological malignancies and cancer. The difficulty of isolating antigen-specific T lymphocytes for individual patients limits the more widespread use o... Read More about WT1-specific T cell receptor gene therapy: Improving TCR function in transduced T cells.