Sara Ghorashian
Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation
Ghorashian, Sara; Wright, Graham; Thomas, Sharyn; Hart, Daniel P.; King, Judy; Voisine, Cecile; Pospori, Constandina; Perro, Mario; Cesco-Gaspere, Michela; Holler, Angelika; Gao, Liquan; Xue, Shao-An; Morris, Emma C.; Chakraverty, Ronjon; Stuass, Hans J.
Authors
Dr Graham Wright G.Wright2@napier.ac.uk
Associate Professor
Sharyn Thomas
Daniel P. Hart
Judy King
Cecile Voisine
Constandina Pospori
Mario Perro
Michela Cesco-Gaspere
Angelika Holler
Liquan Gao
Shao-An Xue
Emma C. Morris
Ronjon Chakraverty
Hans J. Stuass
Contributors
Yair Reisner
Editor
Massimo F. Martelli
Editor
Abstract
Allogeneic hematopoietic stem cell transplantation (HSCT) is carried out to correct genetic disorders of the hematopoietic system, as well as to treat hematopoietic malignancies. Adoptive Tcell therapy has great potential as an adjunct to this treatment modality, and clinical trials have already demonstrated the feasibility and efficacy of this approach. It offers two therapeutic effects in this setting:
(1) Augmentation of anti-tumor responses, such as in the setting of relapsed disease; (2) Prevention and treatment of transplant-related infections.
Underlying the therapeutic efficacy of adoptive T cell therapy is the demonstration of a graft-vs-leukemia/lymphoma (GvL) effect
Citation
Ghorashian, S., Wright, G., Thomas, S., Hart, D. P., King, J., Voisine, C., Pospori, C., Perro, M., Cesco-Gaspere, M., Holler, A., Gao, L., Xue, S.-A., Morris, E. C., Chakraverty, R., & Stuass, H. J. (2010). Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation. In Y. Reisner, & M. F. Martelli (Eds.), Bone Marrow Transplantation Across Major Genetic Barriers (373-395). World Scientific. https://doi.org/10.1142/9789814271271_0016
Online Publication Date | May 1, 2015 |
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Publication Date | Jan 1, 2010 |
Deposit Date | May 4, 2020 |
Pages | 373-395 |
Book Title | Bone Marrow Transplantation Across Major Genetic Barriers |
DOI | https://doi.org/10.1142/9789814271271_0016 |
Public URL | http://researchrepository.napier.ac.uk/Output/2658343 |
Publisher URL | https://www.worldscientific.com/doi/abs/10.1142/9789814271271_0016 |
Contract Date | May 5, 2009 |
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