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Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA (1995)
Journal Article
Bhandal, N. S., Ramsey, R. L., Harvey, R. J., Darlison, M. G., & Usherwood, P. N. R. (1995). Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA. Invertebrate Neuroscience, 1(3), 267-272. https://doi.org/10.1007/bf02211028

We have previously described the isolation of a complementary DNA (cDNA) from the freshwater molluscLymnaea stagnalis encoding a polypeptide that exhibits ∼50{%} identity to the {ß}-subunits of vertebrate $γ$-aminobutyric acid (GABA) type A (GABAA) r... Read More about Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA.

Schizophrenia and GABAA receptor subunit genes (1995)
Journal Article
Byerley, W., Bailey, M. E., Hicks, A. A., Riley, B. P., Darlison, M. G., Holik, J., …Coon, H. (1995). Schizophrenia and GABAA receptor subunit genes. Psychiatric Genetics, 5(1), 23-30. https://doi.org/10.1097/00041444-199521000-00004

Alterations in γ-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for... Read More about Schizophrenia and GABAA receptor subunit genes.

Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization (1995)
Journal Article
MacCallum, J., Poulsom, R., Hanby, A., & Miller, W. (1995). Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization. The Breast, 4(4), 289-296. https://doi.org/10.1016/s0960-9776%2895%2980006-9

As transforming growth factor betas (TGFβs) are of potential importance in the natural history of breast cancer, it is desirable to develop assays which allow detection of the isoforms of TGFβ, at the level of mRNA and protein in clinical material. I... Read More about Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization.

Current perspectives on glycopeptide resistance. (1995)
Journal Article
Woodford, N., Johnson, A. P., Morrison, D. & Speller, D. C. (1995). Current perspectives on glycopeptide resistance. Clinical Microbiology Reviews. 8. . 585-615. . ISSN 0893-8512.

In the last 5 years, clinical isolates of gram-positive bacteria with intrinsic or acquired resistance to glycopeptide antibiotics have been encountered increasingly. In many of these isolates, resistance arises from an alteration of the antibiotic t... Read More about Current perspectives on glycopeptide resistance..

The 'information society' as paradigm: a bibliometric inquiry (1995)
Journal Article
Duff, A. (1995). The 'information society' as paradigm: a bibliometric inquiry. Journal of Information Science, 21(5), 390-395. https://doi.org/10.1177/016555159502100506

It has been claimed that the 'information society' constitutes a new paradigm. The paper describes the use of online bibliometrics to investigate this claim. The methodology involved systematic searching of the databases Information Science Abstracts... Read More about The 'information society' as paradigm: a bibliometric inquiry.

Metal cation uptake by yeast: a review (1995)
Journal Article
Blackwell, K. J., Singleton, I., & Tobin, J. M. (1995). Metal cation uptake by yeast: a review. Applied microbiology and biotechnology, 43(4), 579-584. https://doi.org/10.1007/s002530050454

This review addresses metal uptake specifically by yeast. Metal uptake may be passive, active or both, depending on the viability of the biomass, and is influenced by a number of environmental and experimental factors. Uptake is typically accompanied... Read More about Metal cation uptake by yeast: a review.

The embryonal carcinoma cell line PCC7-S-AzaR: 21.21: 21.2 (clone 1009) expresses a functional GABA: 21.2A: 21.2 receptor comprising the α5, β3 and γ3 subunits: 21.2 (1995)
Journal Article
Harvey, R. J., Lobron, C., Reinhardt-Maelicke, S., Maelicke, A., & Darlison, M. G. (1995). The embryonal carcinoma cell line PCC7-S-AzaR: 21.21: 21.2 (clone 1009) expresses a functional GABA: 21.2A: 21.2 receptor comprising the α5, β3 and γ3 subunits: 21.2. Behavioural Pharmacology, 6(SUPPLEMENT 1), 119. https://doi.org/10.1097/00008877-199505001-00138

Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major (1995)
Journal Article
Proudfoot, L., Schneider, P., Ferguson, M. A. J., & McConville, M. J. (1995). Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major. The biochemical journal, 308(1), 45-55. https://doi.org/10.1042/bj3080045

The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a glycosylphosphatidylinositol glycolipid anchor. This parasite also synthesizes a complex family of abundant low-molecular-... Read More about Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major.

GABAAreceptor subtypes: which, where and why? (1995)
Journal Article
Darlison, M. G., & Albrecht, B. E. (1995). GABAAreceptor subtypes: which, where and why?. Seminars in the neurosciences, 7(2), 115-126. https://doi.org/10.1006/smns.1995.0013

Synaptic inhibition in the vertebrate central nervous system is mediated predominantly by subtypes of the GABAAreceptor, which comprise different pentameric combinations of the products of 13 genes. In this article, we review the results of recent ex... Read More about GABAAreceptor subtypes: which, where and why?.

Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes (1995)
Journal Article
Albrecht, B. E., & Darlison, M. G. (1995). Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes. Neuroscience Letters, 189(3), 155-158. https://doi.org/10.1016/0304-3940%2895%2911479-g

We have amplified partial complementary {DNAs} for the chicken γ-aminobutyric acid type C (GABAC) receptor ρ1 and ρ2 subunits using the polymerase chain reaction. These nucleotide sequences have been utilized to design specific oligonucleotide probes... Read More about Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes.

Considerations on the use of commercially available yeast biomass for the treatment of metal-containing effluents (1995)
Journal Article
Simmons, P., Tobin, J. M., & Singleton, I. (1995). Considerations on the use of commercially available yeast biomass for the treatment of metal-containing effluents. Journal of industrial microbiology, 14(3-4), 240-246. doi:10.1007/bf01569934

Three strains ofSaccharomyces cerevisiae and one strain of aCandida sp. obtained from different industrial sources were screened for uptake of silver and copper. Considerable differences in metal uptake capacities were found between the different str... Read More about Considerations on the use of commercially available yeast biomass for the treatment of metal-containing effluents.

Parasites and Food Web Patterns (1995)
Journal Article
Huxham, M., Raffaelli, D., & Pike, A. (1995). Parasites and Food Web Patterns. Journal of Animal Ecology, 64(2), 168-176. doi:10.2307/5752

1. We expanded two previously studied food webs, those of the Ythan estuary and Loch Leven, by the documentation of metazoan endoparasites present in each system. The resulting webs are the first in the literature to contain substantial numbers of pa... Read More about Parasites and Food Web Patterns.

Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages (1995)
Journal Article
Proudfoot, L., O'Donnell, C. A., & Liew, F. Y. (1995). Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages. European Journal of Immunology, 25(3), 745-750. https://doi.org/10.1002/eji.1830250318

Murine macrophages express high levels of inducible nitric oxide (NO) synthase and produce large amounts of nitric oxide when activated with interferon-gamma and lipopolysaccharide in vitro. Nitric oxide is a mediator of a variety of biological funct... Read More about Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages.

The physiological demands of Gaelic football. (1995)
Journal Article
Florida-James, G., & Reilly, T. (1995). The physiological demands of Gaelic football. British Journal of Sports Medicine, 29(1), 41-45. doi:10.1136/bjsm.29.1.41

Match-lay demands of Gaelic football and fitness profiles were assessed at club competitive level. English Gaelic football club championship players (n = 11) were assessed for anthropometry, leg strength and time to exhaustion on a treadmill run. A s... Read More about The physiological demands of Gaelic football..

Isolation and sequence analysis of the chicken GABAa receptor α1-subunit gene promoter (1995)
Journal Article
Bateson, A. N., Ultsch, A., & Darlison, M. G. (1995). Isolation and sequence analysis of the chicken GABAa receptor α1-subunit gene promoter. Gene, 153(2), 243-247. https://doi.org/10.1016/0378-1119%2894%2900776-o

A genomic clone containing the 5'-flanking sequence of the chicken {GABAA} receptor α1-subunit-encoding gene (GabRα1) was isolated and characterized. An intron was found to interrupt the 5'-untranslated region. The transcription start point (tsp) was... Read More about Isolation and sequence analysis of the chicken GABAa receptor α1-subunit gene promoter.

The Production of a Stably Transformed Insect Cell Line Expressing An Invertebrate GABA A Receptor β-Subunit (1995)
Journal Article
Smith, L. A., Amar, M., Harvey, R. J., Darlison, M. G., Earley, F. G. P., Beadle, D. J., King, L. A., & Bermudez, I. (1995). The Production of a Stably Transformed Insect Cell Line Expressing An Invertebrate GABA A Receptor β-Subunit. Journal of Receptors and Signal Transduction, 15(1-4), 33-41. https://doi.org/10.3109/10799899509045205

We have produced a stable insect cell line derived from Spodoptera frugiperda (Sf9) cells expressing a cDNA encoding a β-subunit of the Lymnaea stagnalis GABAA receptor. The cDNA was randomly integrated into the insect cell genome under the control o... Read More about The Production of a Stably Transformed Insect Cell Line Expressing An Invertebrate GABA A Receptor β-Subunit.

The effect of larval trematodes on the growth and burrowing behaviour of Hydrobia ulvae (gastropoda:prosobranchiata) in the Ythan estuary, north-east Scotland (1995)
Journal Article
Huxham, M., Raffaelli, D., & Pike, A. W. (1995). The effect of larval trematodes on the growth and burrowing behaviour of Hydrobia ulvae (gastropoda:prosobranchiata) in the Ythan estuary, north-east Scotland. Journal of Experimental Marine Biology and Ecology, 185(1), (1-17). doi:10.1016/0022-0981(94)00119-x. ISSN 0022-0981

Hydrobia ulvae were collected from five areas on the Ythan estuary, and the prevalences of digenean parasites in the samples compared. Differences in mean shell height were best explained by differences in parasite prevalence. All snails larger than... Read More about The effect of larval trematodes on the growth and burrowing behaviour of Hydrobia ulvae (gastropoda:prosobranchiata) in the Ythan estuary, north-east Scotland.

Fertility and the menopause. (1994)
Journal Article
Chalmers, C. (1993). Fertility and the menopause. British Journal of Nursing, ISSN 0966-0461