Barbara E. Albrecht
Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes
Albrecht, Barbara E.; Darlison, Mark G.
Authors
Mark G. Darlison
Abstract
We have amplified partial complementary {DNAs} for the chicken γ-aminobutyric acid type C (GABAC) receptor ρ1 and ρ2 subunits using the polymerase chain reaction. These nucleotide sequences have been utilized to design specific oligonucleotide probes for the in situ hybridization localization of the corresponding messenger {RNAs} (mRNAs) in the 1-day-old chick retina. Although both transcripts are found almost exclusively in the inner nuclear layer, their distributions differ markedly. From the locations of the hybridization signals, we deduce that the ρ1-subunit mRNA is present mainly in bipolar cells and that the ρ2-subunit mRNA is present in both amacrine and horizontal cells. These results suggest that the ρ1 and ρ2 subunits frequently occur in different receptor complexes and, therefore, that subtypes of the {GABAC} receptor exist.
Citation
Albrecht, B. E., & Darlison, M. G. (1995). Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes. Neuroscience Letters, 189(3), 155-158. https://doi.org/10.1016/0304-3940%2895%2911479-g
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 17, 1995 |
Publication Date | Apr 21, 1995 |
Deposit Date | Jul 27, 2016 |
Journal | Neuroscience Letters |
Print ISSN | 0304-3940 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 189 |
Issue | 3 |
Pages | 155-158 |
DOI | https://doi.org/10.1016/0304-3940%2895%2911479-g |
Keywords | General Neuroscience |
Public URL | http://researchrepository.napier.ac.uk/Output/317695 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/030439409511479G |
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