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Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation (2022)
Presentation / Conference Contribution
Lynen, F., Russo, G., & Gallikova, J. (2022, May 18-20). Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation [Paper presentation]. 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium.

In this work fused deposition modeling (FDM) based 3D-printing is used for the manufacturing of cartridges for solid phase extraction. The novelty of the approach is that the 3D-printing is used for the simultaneous printing of the porous retentive b... Read More about Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation.

De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater (2022)
Presentation / Conference Contribution
Kajtazi, g., Wicht, K., Russo, G., Eghbali, H., & Lynen, F. (2022, May 18-20). De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater [Poster]. 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium.

Micropollutants, such as pharmaceuticals, industrial chemicals, steroid hormones, etc. are defined as anthropogenic chemicals and can be found in water. It is seen as a serious threat, not just to aquatic life but also to humans, which requires the a... Read More about De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater.

Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules (2022)
Presentation / Conference Contribution
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., Rocco, D., & Vitale, M. (n.d.). Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules [Conference Abstract]. European Congress of Endocrinology 2022, Milan, Italy. https://doi.org/10.1530/endoabs.81.p394

Introduction: The plasticizer Bisphenol A (BPA) is an endocrine disruptor with thyroid interfering activity. Obesity is a recognized risk factor for thyroid cancer. A recent study showed that subjects with BMI ≥ 25 are more prone to BPA-related thyro... Read More about Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules.

Modeling the blood brain barrier permeation of drugs by biomimetic liquid chromatography (2022)
Presentation / Conference Contribution
Russo, G. (2022, March 15). Modeling the blood brain barrier permeation of drugs by biomimetic liquid chromatography [Presentation / Talk]. 1st Scotland - Rheinland-Pfalz Life Sciences and Biotechnology Conference, Online. https://hopin.com/events/1st-scotland-rheinland-pfalz-life-sciences-and-biotechnology-conference/registration

cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity? (2021)
Journal Article
Grumetto, L., & Russo, G. (2021). cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?. ADMET and DMPK, 9(4), 267-281. https://doi.org/10.5599/admet.1034

56 compounds, whose log BB values were known from the scientific literature, were considered and their phospholipophilicity values were calculated in silico. These values, along with either experimentally determined or calculated lipophilicity values... Read More about cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?.

Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis (2021)
Journal Article
Russo, G., Vallaro, M., Cappelli, L., Anderson, S., Ermondi, G., & Caron, G. (2021). Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis. Journal of Chromatography A, 1651, 462316. https://doi.org/10.1016/j.chroma.2021.462316

CelerisTM Arginine (ARG) is a mixed-mode stationary phase recently released on the market. To characterize its analytical behavior, the retention factors of a pool (n=100, of which 36 neutrals, 26 acids and 38 bases) of pharmaceutically relevant comp... Read More about Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis.

Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells (2021)
Journal Article
Russo, G., Iaccarino, G., Piccolo, M., Ferraro, M. G., Vecchione, R., Grumetto, L., Netti, P. A., & Santamaria, R. (2021). Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells. European Journal of Pharmaceutical Sciences, 162, 105825. https://doi.org/10.1016/j.ejps.2021.105825

A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form and termed rMnSOD. As compared to other SODs, this isoform exhibits a dramatically improved cellular uptake and an int... Read More about Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells.

The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy (2021)
Journal Article
Russo, G., Laneri, S., Di Lorenzo, R., Ferrara, L., & Grumetto, L. (2021). The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy. Water Environment Research, 93(10), 1944-1958. https://doi.org/10.1002/wer.1566

Endocrine disrupting chemicals (EDCs) are agents able to exert perturbation toward the endocrine system via a broad array of signalling pathways. Some EDCs are released into the environment as a result of antropogenic activities. Analytical surveilla... Read More about The occurrence of selected endocrine‐disrupting chemicals in water and sediments from an urban lagoon in Southern Italy.

Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment (2021)
Journal Article
Akhbarizadeh, R., Russo, G., Rossi, S., Golianova, K., Moore, F., Guida, M., De Falco, M., & Grumetto, L. (2021). Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment. Marine Pollution Bulletin, 166, 112241. https://doi.org/10.1016/j.marpolbul.2021.112241

The occurrence of endocrine disrupting chemicals (EDCs) has been determined in two widely consumed fish species from Persian Gulf i.e., Epinephelus coioides and Platycephalus indicus by applying a validated analytical for the simultaneous detection o... Read More about Emerging endocrine disruptors in two edible fish from the Persian Gulf: Occurrence, congener profile, and human health risk assessment.

Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development (2020)
Journal Article
Russo, G., Grumetto, L., Baert, M., & Lynen, F. (2021). Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development. Analytica Chimica Acta, 1142, 157-168. https://doi.org/10.1016/j.aca.2020.11.003

A comprehensive two-dimensional liquid chromatography-based biomimetic platform (LCxLC) has been developed and validated for drug diffusion studies. Human serum albumin (HSA) and immobilized artificial membrane (IAM) were thereby used in the first (1... Read More about Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development.

Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity (2020)
Journal Article
Russo, G., Ermondi, G., Caron, G., Verzele, D., & Lynen, F. (2021). Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity. European Journal of Pharmaceutical Sciences, 156, 105585. https://doi.org/10.1016/j.ejps.2020.105585

State of the art: Sphingomyelin (SPH) is a type of sphingolipid found in animal nerve tissues, especially in the membranous myelin sheath that surrounds some nerve cell axons. Because of its characteristics, SPH stationary phase represents an ideal t... Read More about Into the first biomimetic sphingomyelin stationary phase: Suitability in drugs’ biopharmaceutic profiling and block relevance analysis of selectivity.

Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution (2019)
Journal Article
Russo, G., Grumetto, L., Mita, D. G., Rossi, S., Guida, M., Di Marco Pisciottano, I., & Gallo, P. (2019). Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution. Desalination and Water Treatment, 170, 158-167. https://doi.org/10.5004/dwt.2019.24651

The removal of 17alfa-ethinylestradiol (EE2) from synthetic aqueous solutions under adsorption process and enzyme catalysis mediated by immobilized laccase from Trametes versicolor was studied. Both processes were carried... Read More about Coupling of chemical and biological processes in 17alfa-ethinylestradiol removal from aqueous solutions: a critical evaluation of adsorption and catalysis contribution.

Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection (2019)
Journal Article
Del Prete, S., Marasco, D., Del Prete, A., Meloni, M., Capaldi, R., Grumetto, L., & Russo, G. (2019). Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection. Archives of Case Reports, 3(1), 50-53. https://doi.org/10.29328/journal.acr.1001024

Purpose: This work is aimed at demonstrating that scraping cytology and scanning electron microscopy can successfully assist in the diagnosis of nontuberculous mycobacteria infection. For this purpose, we report the use of both these techniques in th... Read More about Scraping cytology and scanning electron microscopy in diagnosis and therapy of corneal ulcer by mycobacterium infection.

Are Canned Beverages Industries Progressively Switching to Bisphenol AF? (2019)
Journal Article
Russo, G., Varriale, F., Barbato, F., & Grumetto, L. (2019). Are Canned Beverages Industries Progressively Switching to Bisphenol AF?. Journal of Food Science, 84(11), 3303-3311. https://doi.org/10.1111/1750-3841.14833

Seven bisphenols, endocrine‐disruptor chemicals, were analytically determined for risk assessment in 52 large‐consumption beverages collected from the Italian market. The analytes under examination were bisphenol A, bisphenol F, bisphenol E, bispheno... Read More about Are Canned Beverages Industries Progressively Switching to Bisphenol AF?.

Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe (2019)
Journal Article
Russo, G., Barbato, F., Mita, D. G., & Grumetto, L. (2019). Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe. Food and Chemical Toxicology, 131, 110575. https://doi.org/10.1016/j.fct.2019.110575

Bisphenol A and its analogues belong to the class of endocrine disrupting chemicals, massively employed by industries to produce polycarbonate and epoxy resins, designed to be in direct contact with foodstuffs. Their leaching from the canned packagin... Read More about Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe.

Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography (2019)
Journal Article
Russo, G., Barbato, F., Grumetto, L., Philippe, L., Lynen, F., & Goetz, G. H. (2019). Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography. International Journal of Pharmaceutics, 560, 294-305. https://doi.org/10.1016/j.ijpharm.2019.02.008

The present work proposes a novel application of EPSA (not an acronym but found to be referred to by many as Exposed Polar Surface Area), a supercritical fluid chromatography (SFC) polarity readout for assisting in the prediction of the extent of dru... Read More about Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.

Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions (2019)
Journal Article
Grumetto, L., Barbato, F., & Russo, G. (2019). Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions. Environmental Toxicology and Pharmacology, 68, 148-154. https://doi.org/10.1016/j.etap.2019.02.008

The interactions between human serum albumin (HSA) and α1- acid glycoprotein (AGP), the main plasma proteins binding drugs/xenobiotics, and some endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA) and some of its structural analogues, bi... Read More about Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions.

Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method (2018)
Journal Article
Russo, G., Barbato, F., Mita, D. G., & Grumetto, L. (2019). Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method. Biomedical Chromatography, 33(3), e4427. https://doi.org/10.1002/bmc.4427

A quick and inexpensive validated method, based on sample treatment by liquid–liquid microextraction followed by liquid chromatography (LC) coupled with ultraviolet tandem fluorescence detection is proposed for the determination of 15 multiclass poll... Read More about Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method.

Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules (2018)
Journal Article
Marotta, V., Russo, G., Gambardella, C., Grasso, M., La Sala, D., Chiofalo, M. G., D'Anna, R., Puzziello, A., Docimo, G., Masone, S., Barbato, F., Colao, A., Faggiano, A., & Grumetto, L. (2019). Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules. Chemosphere, 218, 885-894. https://doi.org/10.1016/j.chemosphere.2018.11.084

Pollutants represent potential threats to the human health, being ubiquitous in the environment and exerting toxicity even at low doses. This study aims at investigating the role of fifteen multiclass organic pollutants, assumed as markers of environ... Read More about Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules.