All Outputs (33)

Seasonal Variation in Vascular Dysfunction: A Systematic Review and Recommendations for Future Research (2024)
Journal Article
Gordon, A., Ross, M., Weston, K., Neubeck, L., & Muggeridge, D. (online). Seasonal Variation in Vascular Dysfunction: A Systematic Review and Recommendations for Future Research. International Journal of Environmental Health Research, https://doi.org/10.1080/09603123.2024.2432562

Vascular function serves as a prognostic marker for cardiovascular disease and may exhibit seasonal variations due to lifestyle and environmental factors. Our systematic review aimed to determine whether seasonal variations in vascular function are p... Read More about Seasonal Variation in Vascular Dysfunction: A Systematic Review and Recommendations for Future Research.

Performance benchmarking microplate-immunoassays for quantifying target-specific cysteine oxidation reveals their potential for understanding redox-regulation and oxidative stress (2023)
Journal Article
Tuncay, A., Crabtree, D. R., Muggeridge, D. J., Husi, H., & Cobley, J. N. (2023). Performance benchmarking microplate-immunoassays for quantifying target-specific cysteine oxidation reveals their potential for understanding redox-regulation and oxidative stress. Free Radical Biology and Medicine, 204, 252-265. https://doi.org/10.1016/j.freeradbiomed.2023.05.006

The antibody-linked oxi-state assay (ALISA) for quantifying target-specific cysteine oxidation can benefit specialist and non-specialist users. Specialists can benefit from time-efficient analysis and high-throughput target and/or sample n-plex capac... Read More about Performance benchmarking microplate-immunoassays for quantifying target-specific cysteine oxidation reveals their potential for understanding redox-regulation and oxidative stress.

LC/MS-based discrimination between plasma and urine metabolomic changes following exposure to ultraviolet radiation by using data modelling (2023)
Journal Article
Ali, A. M., Monaghan, C., Muggeridge, D. J., Easton, C., & Watson, D. G. (2023). LC/MS-based discrimination between plasma and urine metabolomic changes following exposure to ultraviolet radiation by using data modelling. Metabolomics, 19(2), Article 13. https://doi.org/10.1007/s11306-023-01977-0

Introduction: This study sought to compare between metabolomic changes of human urine and plasma to investigate which one can be used as best tool to identify metabolomic profiling and novel biomarkers associated to the potential effects of ultraviol... Read More about LC/MS-based discrimination between plasma and urine metabolomic changes following exposure to ultraviolet radiation by using data modelling.

Reduced nitric oxide synthesis in winter: A potential contributing factor to increased cardiovascular risk (2022)
Journal Article
Liddle, L., Monaghan, C., Burleigh, M. C., Baczynska, K. A., Muggeridge, D. J., & Easton, C. (2022). Reduced nitric oxide synthesis in winter: A potential contributing factor to increased cardiovascular risk. Nitric Oxide: Biology and Chemistry, 127, 1-9. https://doi.org/10.1016/j.niox.2022.06.007

Background
Nitric oxide is a key signalling molecule that elicits a range of biological functions to maintain vascular homeostasis. A reduced availability of nitric oxide is implicated in the progression of cardiovascular diseases and increases the... Read More about Reduced nitric oxide synthesis in winter: A potential contributing factor to increased cardiovascular risk.

Clinical and health economic evaluation of a post-stroke arrhythmia monitoring service (2022)
Journal Article
Muggeridge, D., Callum, K., Macpherson, L., Howard, N., Graune, C., Megson, I., Giangreco, A., Gallacher, S., Campbell, L., Williams, G., Macaden, A., & Leslie, S. J. (2022). Clinical and health economic evaluation of a post-stroke arrhythmia monitoring service. British Journal of Cardiology, 29(2), 46-51. https://doi.org/10.5837/bjc.2022.015

Atrial fibrillation (AF) is a major cause of recurrent stroke and transient ischaemic attack (TIA) in the UK. As many patients can have asymptomatic paroxysmal AF, prolonged arrhythmia monitoring is advised in selected patients following a stroke or... Read More about Clinical and health economic evaluation of a post-stroke arrhythmia monitoring service.

Exercise decreases PP2A-specific reversible thiol oxidation in human erythrocytes: Implications for redox biomarkers (2022)
Journal Article
Muggeridge, D. J., Crabtree, D. R., Tuncay, A., Megson, I. L., Davison, G., & Cobley, J. N. (2022). Exercise decreases PP2A-specific reversible thiol oxidation in human erythrocytes: Implications for redox biomarkers. Free Radical Biology and Medicine, 182, 73-78. https://doi.org/10.1016/j.freeradbiomed.2022.02.019

New readily accessible systemic redox biomarkers are needed to understand the biological roles reactive oxygen species (ROS) play in humans because overtly flawed, technically fraught, and unspecific assays severely hamper translational progress. The... Read More about Exercise decreases PP2A-specific reversible thiol oxidation in human erythrocytes: Implications for redox biomarkers.

Does Connected Health Technology Improve Health-Related Outcomes in Rural Cardiac Populations? Systematic Review Narrative Synthesis (2022)
Journal Article
Fraser, M. J., Gorely, T., O’Malley, C., Muggeridge, D. J., Giggins, O. M., & Crabtree, D. R. (2022). Does Connected Health Technology Improve Health-Related Outcomes in Rural Cardiac Populations? Systematic Review Narrative Synthesis. International Journal of Environmental Research and Public Health, 19(4), Article 2302. https://doi.org/10.3390/ijerph19042302

Individuals living in rural areas are more likely to experience cardiovascular diseases (CVD) and have increased barriers to regular physical activity in comparison to those in urban areas. This systematic review aimed to understand the types and eff... Read More about Does Connected Health Technology Improve Health-Related Outcomes in Rural Cardiac Populations? Systematic Review Narrative Synthesis.

Accuracy of Wrist-Worn Photoplethysmography Devices at Measuring Heart Rate in the Laboratory and During Free-Living Activities (2021)
Presentation / Conference Contribution
Giggins, O. M., Doyle, J., Sojan, N., Moran, O., Crabtree, D. R., Fraser, M., & Muggeridge, D. J. (2021, November). Accuracy of Wrist-Worn Photoplethysmography Devices at Measuring Heart Rate in the Laboratory and During Free-Living Activities. Presented at 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC, Mexico

This study compared heart rate (HR) measurements taken from two wrist-worn devices; the Empatica E4 and the Apple Watch Series 5, to that taken from a Polar H10 chest strap. Ten healthy adult volunteers took part in a laboratory validation study and... Read More about Accuracy of Wrist-Worn Photoplethysmography Devices at Measuring Heart Rate in the Laboratory and During Free-Living Activities.

CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients (2021)
Journal Article
Muggeridge, D., Dodd, J., & Ross, M. D. (2021). CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients. Atherosclerosis, 333, 108-115. https://doi.org/10.1016/j.atherosclerosis.2021.07.004

Background and aims
Circulating progenitor cells (CPCs) play an important role in vascular repair and can influence cardiovascular (CV) health and longevity. Exercise is known to modulate these cells via mobilization from the bone marrow. The primar... Read More about CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients.

Validity of the iPhone M7 Motion Coprocessor to Estimate Physical Activity During Structured and Free-Living Activities in Healthy Adults (2021)
Journal Article
Thomson, N. K., McMichan, L., Macrae, E., Baker, J. S., Muggeridge, D. J., & Easton, C. (2021). Validity of the iPhone M7 Motion Coprocessor to Estimate Physical Activity During Structured and Free-Living Activities in Healthy Adults. Journal for the Measurement of Physical Behaviour, 4(3), 212-219. https://doi.org/10.1123/jmpb.2020-0067

Modern smartphones such as the iPhone contain an integrated accelerometer, which can be used to measure body movement and estimate the volume and intensity of physical activity. Objectives: The primary objective was to assess the validity of the iPho... Read More about Validity of the iPhone M7 Motion Coprocessor to Estimate Physical Activity During Structured and Free-Living Activities in Healthy Adults.

Measurement of Heart Rate Using the Polar OH1 and Fitbit Charge 3 Wearable Devices in Healthy Adults During Light, Moderate, Vigorous, and Sprint-Based Exercise: Validation Study (2021)
Journal Article
Muggeridge, D. J., Hickson, K., Davies, A. V., Giggins, O. M., Megson, I. L., Gorely, T., & Crabtree, D. R. (2021). Measurement of Heart Rate Using the Polar OH1 and Fitbit Charge 3 Wearable Devices in Healthy Adults During Light, Moderate, Vigorous, and Sprint-Based Exercise: Validation Study. JMIR mHealth and uHealth, 9(3), Article e25313. https://doi.org/10.2196/25313

Background: Accurate, continuous heart rate measurements are important for health assessment, physical activity, and sporting performance, and the integration of heart rate measurements into wearable devices has extended its accessibility. Although t... Read More about Measurement of Heart Rate Using the Polar OH1 and Fitbit Charge 3 Wearable Devices in Healthy Adults During Light, Moderate, Vigorous, and Sprint-Based Exercise: Validation Study.

Clinical application of physical-activity monitoring in patients with CIEDs (2020)
Journal Article
Callum, K., Muggeridge, D. J., Giggins, O. M., Crabtree, D. R., Gorely, T., & Leslie, S. J. (2020). Clinical application of physical-activity monitoring in patients with CIEDs. British Journal of Cardiology, 27, 115-118. https://doi.org/10.5837/bjc.2020.035

Regular physical activity for secondary prevention in cardiovascular disease has many well-recognised benefits, with declines in physical activity being associated with worsening cardiovascular disease, suboptimal treatment or worsening comorbidities... Read More about Clinical application of physical-activity monitoring in patients with CIEDs.

Venous occlusion during blood collection decreases plasma nitrite but not nitrate concentration in humans (2020)
Journal Article
Liddle, L., Burleigh, M. C., Monaghan, C., Muggeridge, D. J., & Easton, C. (2020). Venous occlusion during blood collection decreases plasma nitrite but not nitrate concentration in humans. Nitric Oxide: Biology and Chemistry, 102, 21-27. https://doi.org/10.1016/j.niox.2020.06.001

Background: To maintain vascular tone and blood flow when tissue oxygenation is reduced, nitrite anions are reduced to nitric oxide (NO). From a practical perspective, it is unclear how the application of a tourniquet during blood collection might in... Read More about Venous occlusion during blood collection decreases plasma nitrite but not nitrate concentration in humans.

High-intensity interval training in patients with heart failure (2020)
Journal Article
Callum, K. J., Gorely, T., Crabtree, D. R., Muggeridge, D. J., & Leslie, S. J. (2020). High-intensity interval training in patients with heart failure. British Journal of Cardiac Nursing, 15(4), 1-13. https://doi.org/10.12968/bjca.2019.0058

Cardiac rehabilitation is a key component in the secondary prevention of cardiovascular disease. However, uptake and adherence to programmes is suboptimal, especially for patients with heart failure. Traditionally, cardiac rehabilitation programmes h... Read More about High-intensity interval training in patients with heart failure.

Exploring the mechanisms by which nitrate supplementation improves skeletal muscle contractile function: one fibre at a time (2019)
Journal Article
McIlvenna, L. C., Muggeridge, D. J., & Whitfield, J. (2020). Exploring the mechanisms by which nitrate supplementation improves skeletal muscle contractile function: one fibre at a time. Journal of Physiology, 598(1), 25-27. https://doi.org/10.1113/jp279118

No abstract available.

Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers (2019)
Journal Article
Muggeridge, D. J., Goszcz, K., Treweeke, A., Adamson, J., Hickson, K., Crabtree, D., & Megson, I. L. (2019). Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers. Frontiers in Physiology, 10, Article 1293. https://doi.org/10.3389/fphys.2019.01293

Eating a high calorie meal is known to induce endothelial dysfunction and it is reported that consuming drinks rich in antioxidants may be protective against this. In this study we assessed the effects of three antioxidant drinks with considerable di... Read More about Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers.

Dietary nitrate supplementation alters the oral microbiome but does not improve the vascular responses to an acute nitrate dose (2019)
Journal Article
Burleigh, M., Liddle, L., Muggeridge, D. J., Monaghan, C., Sculthorpe, N., Butcher, J., Henriquez, F., & Easton, C. (2019). Dietary nitrate supplementation alters the oral microbiome but does not improve the vascular responses to an acute nitrate dose. Nitric Oxide: Biology and Chemistry, 89, 54-63. https://doi.org/10.1016/j.niox.2019.04.010

Nitrate (NO3−) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2−) by commensal bacteria in the oral cavity. We tested the hypothesis that regular ingestion of dieta... Read More about Dietary nitrate supplementation alters the oral microbiome but does not improve the vascular responses to an acute nitrate dose.

Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists (2019)
Journal Article
McIlvenna, L. C., Muggeridge, D. J., Forrest (Nee Whyte), L. J., Monaghan, C., Liddle, L., Burleigh, M. C., Sculthorpe, N., Fernandez, B. O., Feelisch, M., & Easton, C. (2019). Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists. Journal of Science and Medicine in Sport, 22(7), 852-857. https://doi.org/10.1016/j.jsams.2019.01.011

OBJECTIVES: Dietary nitrate (NO3-) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore whether NO3- supplementation, ingested prior to an IPC protocol, could syn... Read More about Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists.

An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions (2019)
Journal Article
Smith, K., Muggeridge, D. J., Easton, C., & Ross, M. D. (2019). An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions. European Journal of Applied Physiology, 119(3), 723-733. https://doi.org/10.1007/s00421-018-04063-9

Purpose: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions. However, the ergogenic effects of dietary NO3- on intermittent exercise performance in hot conditions has... Read More about An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions.

Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference (2018)
Journal Article
Liddle, L., Burleigh, M. C., Monaghan, C., Muggeridge, D. J., Sculthorpe, N., Pedlar, C. R., Butcher, J., Henriquez, F. L., & Easton, C. (2019). Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference. Nitric Oxide: Biology and Chemistry, 83, 1-10. https://doi.org/10.1016/j.niox.2018.12.003

There is conflicting evidence on whether dietary nitrate supplementation can improve exercise performance. This may arise from the complex nature of nitric oxide (NO) metabolism which causes substantial inter-individual variability, within-person bio... Read More about Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference.