Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists

McIlvenna, Luke C.; Muggeridge, David J.; Forrest (Nee Whyte), Laura J.; Monaghan, Chris; Liddle, Luke; Burleigh, Mia C.; Sculthorpe, Nicholas; Fernandez, Bernadette O.; Feelisch, Martin; Easton, Chris

Abstract

OBJECTIVES: Dietary nitrate (NO3-) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore whether NO3- supplementation, ingested prior to an IPC protocol, could synergistically enhance parameters of exercise.

DESIGN: Double-blind randomized crossover trial.

METHODS: Ten competitive male cyclists (age 34±6years, body mass 78.9±4.9kg, V⋅O2peak 55±4 mLkgmin-1) completed an incremental exercise test followed by three cycling trials comprising a square-wave submaximal component and a 16.1km time-trial. Oxygen uptake (V⋅O2) and muscle oxygenation kinetics were measured throughout. The baseline (BASE) trial was conducted without any dietary intervention or IPC. In the remaining two trials, participants received 3×5min bouts of lower limb bilateral IPC prior to exercise. Participants ingested NO3--rich gel (NIT+IPC) 90min prior to testing in one trial and a low NO3- placebo in the other (PLA+IPC). Plasma NO3- and nitrite (NO2-) were measured immediately before and after application of IPC.

RESULTS: Plasma [NO3-] and [NO2-] were higher before and after IPC in NIT+IPC compared to BASE (P0.4). Performance in the time-trial was similar between trials (BASE 1343±72s, PLA+IPC 1350±75s, NIT+IPC 1346±83s, P=0.98).

CONCLUSIONS: Pre-exercise IPC did not improve sub-maximal exercise or performance measures, either alone or in combination with dietary NO3- supplementation.

Citation

McIlvenna, L. C., Muggeridge, D. J., Forrest (Nee Whyte), L. J., Monaghan, C., Liddle, L., Burleigh, M. C., …Easton, C. (2019). Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists. Journal of Science and Medicine in Sport, 22(7), 852-857. https://doi.org/10.1016/j.jsams.2019.01.011

• Journal Article Type: Article
• Acceptance Date: Jan 18, 2019
• Online Publication Date: Jan 25, 2019
• Publication Date: 2019-07
• Deposit Date: Oct 22, 2020
• Publicly Available Date: Oct 23, 2020
• Journal: Journal of Science and Medicine in Sport
• Print ISSN: 1440-2440
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 7
• Pages: 852-857
• DOI: https://doi.org/10.1016/j.jsams.2019.01.011
• Keywords: Nitric oxide, Blood flow, Hyperaemia, Nitrite, Exercise
• Public URL: http://researchrepository.napier.ac.uk/Output/2694086