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Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors (1988)
Book Chapter
Marshall, J., David, J. A., Darlison, M. G., Barnard, E. A., & Sattelle, D. B. (1988). Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors. In Nicotinic Acetylcholine Receptors in the Nervous System (257-281). Springer. https://doi.org/10.1007/978-3-642-74167-8_20

There is considerable evidence that acetylcholine is an excitatory neurotransmitter at many synapses in the insect central nervous system (Sattelle 1986). Despite the acute technical difficulties of proving that a putative transmitter exerts a functi... Read More about Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors.

Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain (1988)
Journal Article
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1988). Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain. Neuron, 1(10), 937-947. https://doi.org/10.1016/0896-6273%2888%2990151-1

Specific oligonucleotide probes have been used to visualize the regional and cellular distribution of the mRNAs encoding three structurally distinct GABA A receptor α subunits in bovine brain. In situ hybridization analysis showed that these transcri... Read More about Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain.

Structural and functional basis for GABAA receptor heterogeneity (1988)
Journal Article
Levitan, E. S., Schofield, P. R., Burt, D. R., Rhee, L. M., Wisden, W., Köhler, M., …Seeburg, P. H. (1988). Structural and functional basis for GABAA receptor heterogeneity. Nature, 335(6185), 76-79. https://doi.org/10.1038/335076a0

When γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in vertebrate brain, binds to its receptor it activates a chloride channel. Neurotransmitter action at the GABAA receptor is potentiated by both benzodiazepines and barbiturates w... Read More about Structural and functional basis for GABAA receptor heterogeneity.

Molecular biology of the GABAA receptor: the receptor/channel superfamily (1987)
Journal Article
Barnard, E. A., Darlison, M. G., & Seeburg, P. (1987). Molecular biology of the GABAA receptor: the receptor/channel superfamily. Trends in Neurosciences, 10(12), 502-509. doi:10.1016/0166-2236(87)90130-5

Complementary DNAs encoding the two subunit types of the brain GABAA receptor have been cloned, revealing its full protein primary structure1. In another laboratory, the same point has now been reached for one of the subunits of the spinal cord glyci... Read More about Molecular biology of the GABAA receptor: the receptor/channel superfamily.

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family (1987)
Journal Article
Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., Seeburg, P. H., & Barnard, E. A. (1987). Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature, 328(6127), 221-227. https://doi.org/10.1038/328221a0

Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-chann... Read More about Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family.

The Molecular Biology of Acetylcholine Receptors from the Vertebrate Peripheral and Central Nervous Systems (1986)
Book Chapter
Jackson, J. F., Beeson, D. M. W., Cockcroft, V. B., Darlison, M. G., Conti-Tronconi, B. M., Bell, L. D., & Barnard, E. A. (1986). The Molecular Biology of Acetylcholine Receptors from the Vertebrate Peripheral and Central Nervous Systems. Molecular Aspects of Neurobiology (66-74). Springer. https://doi.org/10.1007/978-3-642-70690-5_13

Nicotinic acetylcholine receptors (AChR) mediate chemical communication at synapses in many parts of the vertebrate nervous system, including neuromuscular junctions, autonomic ganglia, and certain sites in the brain. This occurs through the interact... Read More about The Molecular Biology of Acetylcholine Receptors from the Vertebrate Peripheral and Central Nervous Systems.

Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain (1986)
Book Chapter
Squire, M. D., Moss, S. J., Lai, F. A., Darlison, M. G., Cockcroft, V. B., Barnard, E. A., Beeson, D. M. W., Hicks, A. A., Darlison, M. G., & Ross, S. J. (1986). Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain. In A. Maelicke (Ed.), Nicotinic Acetylcholine Receptor (389-415). Springer. https://doi.org/10.1007/978-3-642-71649-2_30

While it has been completely established that the AChR** as isolated from the electroplaques of electric fish is composed of four different polypeptides, such that its subunit structure is α2βγδ (as reviewed in detail elsewhere in this Volume), the e... Read More about Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain.

Investigation of the substrate binding sites of elastase (1986)
Thesis
Shah, V. K. Investigation of the substrate binding sites of elastase. (Thesis). Napier College of Commerce and Technology. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/6047

Studies of pancreatic elastase were undertaken to examine substrate binding and of human leukocyte elastase to try to gain insight into the disease, pulmonary emphysema. Porcine pancreatic elastase was inhibited by various inhibitors p-toluene sulpho... Read More about Investigation of the substrate binding sites of elastase.

Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit (1985)
Journal Article
Wiggins, R. C., Glatfelter, A., Campbell, A. M., Kunkel, R. G., & Ulevitch, R. J. (1985). Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit. Circulation Research, 57(2), 262-277. https://doi.org/10.1161/01.res.57.2.262

The hypotension and bradycardia observed after intravenous injection of dextran sulfate in rabbits was prevented by prior depletion of circulating platelets, but was not prevented by depletion of the third component of complement or Hageman factor. D... Read More about Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit.