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Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

Schofield, Peter R.; Darlison, Mark G.; Fujita, Norihisa; Burt, David R.; Stephenson, F. Anne; Rodriguez, Henry; Rhee, Lucy M.; Ramachandran, J.; Reale, Vincenzina; Glencorse, Thora A.; Seeburg, Peter H.; Barnard, Eric A.

Authors

Peter R. Schofield

Mark G. Darlison

Norihisa Fujita

David R. Burt

F. Anne Stephenson

Henry Rodriguez

Lucy M. Rhee

J. Ramachandran

Vincenzina Reale

Thora A. Glencorse

Peter H. Seeburg

Eric A. Barnard



Abstract

Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated α-subunit and β-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.

Citation

Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., Seeburg, P. H., & Barnard, E. A. (1987). Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature, 328(6127), 221-227. https://doi.org/10.1038/328221a0

Journal Article Type Article
Acceptance Date Jun 16, 1987
Publication Date Jul 16, 1987
Deposit Date Aug 5, 2016
Journal Nature
Print ISSN 0028-0836
Electronic ISSN 1476-4687
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 328
Issue 6127
Pages 221-227
DOI https://doi.org/10.1038/328221a0
Keywords Amino-acid sequences, DMAs encoding, GAB A/ benzo diazepine receptor, functional receptor channel,
Public URL http://researchrepository.napier.ac.uk/Output/327807



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