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Hippocalcin functions as a calcium sensor in hippocampal LTD (2005)
Journal Article
Palmer, C., Lim, W., Hastie, P. G. R., Toward, M., Korolchuk, V. I., Burbidge, S. A., Banting, G., Collingridge, G. L., Isaac, J. T. R., & Henley, J. M. (2005). Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron, 47(4), 487-494. https://doi.org/10.1016/j.neuron.2005.06.014

It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the β2-adaptin subunit of the AP2 adaptor complex and that along with GluR2 these coimmunopre... Read More about Hippocalcin functions as a calcium sensor in hippocampal LTD.

Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. (2005)
Journal Article
Dias, N., Goossens, J.-F., Baldeyrou, B., Lansiaux, A., Colson, P., Di Salvo, A., Bernal, J., Turnbull, A., Mincher, D., & Bailly, C. (2005). Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate Chemistry, 16(4), 949-958. https://doi.org/10.1021/bc050065x

We report the synthesis of an original series of oxoazabenzo[de]anthracenes conjugated to an amino acid: Ala, Phe, Pro, Lys, or Gly (4a-e, respectively). The compounds, derived from 1,8-dihydroxyanthracene-9,10-dione, were studied for DNA binding and... Read More about Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents..

Steroid signalling in the ovarian surface epithelium (2005)
Journal Article
Rae, M. T., & Hillier, S. G. (2005). Steroid signalling in the ovarian surface epithelium. Trends in Endocrinology and Metabolism, 16(7), 327-333. https://doi.org/10.1016/j.tem.2005.07.002

Human ovarian surface epithelium (HOSE) undergoes serial injury-repair with each ovulation, which is probably why most ovarian epithelial cancers arise there. Considering the proposed inflammatory aetiology of ovarian cancer, anti-inflammatory steroi... Read More about Steroid signalling in the ovarian surface epithelium.

Partitioning and Bioavailability (2005)
Book Chapter
Philp, J., Stainsby, F., & Dunbar, S. (2005). Partitioning and Bioavailability. In Water encyclopedia. Wiley. https://doi.org/10.1002/047147844x.pc441

As soon as a chemical is spilled it becomes a pollutant, but the fate of that pollutant depends to a large degree on its chemistry, which determines how it will partition to various “compartments,” or phases, of the environment. This idea is enshrine... Read More about Partitioning and Bioavailability.

Targeting an MMP-9-activated prodrug to multiple myeloma-diseased bone marrow: a proof of principle in the 5T33MM mouse model (2005)
Journal Article
Van Valckenborgh, E., Mincher, D., Di Salvo, A., Van Riet, I., Young, L., Van Camp, B., & Vanderkerken, K. (2005). Targeting an MMP-9-activated prodrug to multiple myeloma-diseased bone marrow: a proof of principle in the 5T33MM mouse model. Leukemia, 19(9), 1628-1633. https://doi.org/10.1038/sj.leu.2403866

Multiple myeloma (MM) is an incurable B-cell cancer characterised by the monoclonal proliferation of tumour cells in the bone marrow (BM). It has been described that matrix metalloproteinases (MMPs) and especially MMP-9 is secreted by MM cells. In th... Read More about Targeting an MMP-9-activated prodrug to multiple myeloma-diseased bone marrow: a proof of principle in the 5T33MM mouse model.

A new short-term toxicity assay using Aspergillus awamori with recombinant aequorin gene (2005)
Journal Article
Kozlova, O., Zwinderman, M., & Christofi, N. (2005). A new short-term toxicity assay using Aspergillus awamori with recombinant aequorin gene. BMC Microbiology, 5, Article 40. https://doi.org/10.1186/1471-2180-5-40

Background
Most currently available short-term toxicity assays are based on bacterial cells. Therefore there is a need for novel eukaryotic microbial bioassays that will be relevant to higher eukaryotes such as animals and plants. Ca2+ is a universa... Read More about A new short-term toxicity assay using Aspergillus awamori with recombinant aequorin gene.

The Irish Sea: nutrient status and phytoplankton. (2005)
Journal Article
Gowen, R. J., & Stewart, B. (2005). The Irish Sea: nutrient status and phytoplankton. Journal of Sea Research, 54(1), 36-50. https://doi.org/10.1016/j.seares.2005.02.003

Historical nutrient and phytoplankton data from the Irish Sea are reviewed in the light of recent studies. Mean late winter concentrations of dissolved inorganic nitrogen (DIN as NO3− + NO2−), dissolved inorganic phosphate (DIP as PO43 −) and silica... Read More about The Irish Sea: nutrient status and phytoplankton..

Consequences of the Evolution of the GABAA Receptor Gene Family (2005)
Journal Article
Darlison, M. G., Pahal, I., & Thode, C. (2005). Consequences of the Evolution of the GABAA Receptor Gene Family. Cellular and Molecular Neurobiology, 25(3-4), 607-624. https://doi.org/10.1007/s10571-005-4004-4

1. This paper reviews the evolution of the family of genes present in mammals and other vertebrates that encode $γ$-aminobutyric acid (GABA) type A (GABAA) receptors, which are the major inhibitory neurotransmitter receptors in the central nervous sy... Read More about Consequences of the Evolution of the GABAA Receptor Gene Family.

Globalisation, collective action and counter‐coordination: The use of the new information communication technology by the Malaysian labour movement (2005)
Journal Article
Grieco, M., & Bhopal, M. (2005). Globalisation, collective action and counter‐coordination: The use of the new information communication technology by the Malaysian labour movement. Critical Perspectives on International Business, 1(2/3), 109-122. https://doi.org/10.1108/17422040510595627

This article aims to explore the use of new information communication technology by the Malaysian labour movement. New information communication technologies are undoubtedly globalising, but these same technologies can also be used by labour to retri... Read More about Globalisation, collective action and counter‐coordination: The use of the new information communication technology by the Malaysian labour movement.