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Hippocalcin functions as a calcium sensor in hippocampal LTD

Palmer, Claire; Lim, Wonil; Hastie, Peter G R; Toward, Mark; Korolchuk, Victor I; Burbidge, Stephen A; Banting, George; Collingridge, Graham L; Isaac, John T R; Henley, Jeremy M


Wonil Lim

Peter G R Hastie

Mark Toward

Victor I Korolchuk

Stephen A Burbidge

George Banting

Graham L Collingridge

John T R Isaac

Jeremy M Henley


It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the β2-adaptin subunit of the AP2 adaptor complex and that along with GluR2 these coimmunoprecipitate in a Ca2+-sensitive manner. Infusion of a truncated mutant of hippocalcin (HIP2-72) that lacks the Ca2+ binding domains prevents synaptically evoked LTD but has no effect on LTP. These data indicate that the AP2-hippocalcin complex acts as a Ca2+ sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD.

Journal Article Type Article
Publication Date 2005-08
Deposit Date Jun 24, 2008
Print ISSN 0896-6273
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 47
Issue 4
Pages 487-494
Keywords AMPARs; Hippocalcin; NMDAR-dependent LTDs
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