Steroid signalling in the ovarian surface epithelium

Rae, Michael T.; Hillier, Stephen G.

Abstract

Human ovarian surface epithelium (HOSE) undergoes serial injury-repair with each ovulation, which is probably why most ovarian epithelial cancers arise there. Considering the proposed inflammatory aetiology of ovarian cancer, anti-inflammatory steroid signalling might be vital for {HOSE} regulation. {HOSE} cells express hydroxysteroid dehydrogenase (HSD) enzymes that undertake prereceptor metabolism of bioinert steroidogenic precursors formed elsewhere in the body. Ovulation-associated cytokines activate anti-inflammatory cortisol from precursor cortisone in {HOSE} cells owing to up-regulation of the gene encoding 11βHSD type 1 (HSD11B1) in vitro. Cortisol further enhances its own formation and action through augmentation of cytokine-induced {HSD11B1} and glucocorticoid receptor gene expression. Understanding this feed-forward signalling process has implications for the improved diagnosis and treatment of inflammation-associated reproductive disease states such as ovarian cancer.

Citation

Rae, M. T., & Hillier, S. G. (2005). Steroid signalling in the ovarian surface epithelium. Trends in Endocrinology and Metabolism, 16(7), 327-333. https://doi.org/10.1016/j.tem.2005.07.002

• Journal Article Type: Article
• Online Publication Date: Jul 27, 2005
• Publication Date: 2005-09
• Deposit Date: Jul 27, 2016
• Journal: Trends in Endocrinology & Metabolism
• Print ISSN: 1043-2760
• Electronic ISSN: 1879-3061
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 7
• Pages: 327-333
• DOI: https://doi.org/10.1016/j.tem.2005.07.002
• Keywords: Human ovarian surface epithelium (HOSE), ovarian epithelial cancers,
• Public URL: http://researchrepository.napier.ac.uk/Output/317753
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S1043276005001499