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Outputs (28)

Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling (2024)
Preprint / Working Paper
Elsharkasi, M., Villani, B., Wells, G., & Kerr, F. Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling

As a gate-keeper of anti-oxidant, anti-inflammatory and xenobiotic cell protection mechanisms, the transcription factor Nrf2 has been implicated as a promising therapeutic target for several neurodegenerative diseases, leading to the development of N... Read More about Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling.

Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa (2024)
Journal Article
Orzel, D., Ravald, H., Dillon, A., Rantala, J., Wiedmer, S. K., & Russo, G. (2024). Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa. Journal of Chromatography A, 1734, Article 465286. https://doi.org/10.1016/j.chroma.2024.465286

This study pioneers a comparison of the application of biomimetic techniques, immobilised artificial membrane liquid chromatography (IAM LC) and liposome electrokinetic capillary chromatography (LEKC), for the prediction of pulmonary drug permeabilit... Read More about Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa.

β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting (2024)
Journal Article
Baghestani, S., Haldin, C., Kosijer, P., Alam, C. M., & Toivola, D. M. (2024). β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting. American Journal of Physiology - Cell Physiology, 327(2), C462-C476. https://doi.org/10.1152/ajpcell.00123.2024

Islet β-cell dysfunction is an underlying factor for type I diabetes (T1D) development. Insulin sensing and secretion are tightly regulated in β-cells at multiple subcellular levels. The epithelial intermediate filament (IF) protein keratin (K) 8 is... Read More about β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting.

Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species. Food Standards Agency

An application was submitted to the Food Standards Agency in May 2021 from AlzChem Trostberg GmbH (“the applicant”) for the new use authorisation of an additive guanidinoacetic acid (Creamino®), under the category of ‘nutritional additives” and funct... Read More about Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species.

Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360) (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360). Food Standards Agency

An application was submitted to the Food Standards Agency in March 2021 from DSM Nutritional Products LTD (“the applicant”) for the new authorisation of an additive (ProAct 360) containing protease (subtilisin), under the category of “zootechnical ad... Read More about Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360).

Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®) (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®). Food Standards Agency

An application was submitted to the Food Standards Agency in April 2021 from Phibro Animal Health Corporation (“the applicant”) for the new authorisation of an additive (Magni-Phi®), a natural preparation of powdered dry Quillaja saponaria and dry Yu... Read More about Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®).

Safety Assessment RP416 Axtra XB (2023)
Report
Morrison, D. (2023). Safety Assessment RP416 Axtra XB. Food Standards Agency

An application was submitted to the Food Standards Agency in February 2021 by Genencor International B.V. (“the applicant”) for the authorisation of an additive (endo-1,4-betaxylanase and endo-1,3(4)-beta-glucanase - Axtra® XB), under retained regula... Read More about Safety Assessment RP416 Axtra XB.

Scottish Life And Chemical Science Skills Summit (2023)
Report
Maguire, H., & Garden, C. (2023). Scottish Life And Chemical Science Skills Summit. Edinburgh, UK: Scottish Universities Life Sciences Alliance (SULSA)

The Scottish Life and Chemical Skills Summit was led and hosted by Edinburgh Napier University (ENU) with support from Skills Development Scotland (SDS) and the Scottish Universities Life Sciences Alliance (SULSA).
We would like to thank members of... Read More about Scottish Life And Chemical Science Skills Summit.

Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation (2023)
Journal Article
Duncan, W. C., Nicol, L. M., O’Hare, R., Witherington, J., Miranda, J. A., Campbell, B. K., Thomas, J. L., & Rae, M. T. (2023). Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation. Frontiers in Endocrinology, 14, Article 1285269. https://doi.org/10.3389/fendo.2023.1285269

Introduction: Polycystic ovary syndrome (PCOS) seems to be associated with increased ovarian sympathetic nerve activity and in rodent models of PCOS reducing the sympathetic drive to the ovary, through denervation or neuromodulation, improves ovulati... Read More about Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation.

Beyond the Advanced Therapies Skills Training Network: An Instrumental Case Study of Life Sciences Skills Development for Biomedical Science Graduates in Scotland (2023)
Journal Article
Garden, C. L. P. (2023). Beyond the Advanced Therapies Skills Training Network: An Instrumental Case Study of Life Sciences Skills Development for Biomedical Science Graduates in Scotland. British Journal of Biomedical Science, 80, Article 11654. https://doi.org/10.3389/bjbs.2023.11654

Biomedical sciences graduates are employed in a variety of different settings and form a significant part of the Life Sciences sector workforce in Scotland. Their degrees should equip them with the skills and knowledge to not only enter the workplace... Read More about Beyond the Advanced Therapies Skills Training Network: An Instrumental Case Study of Life Sciences Skills Development for Biomedical Science Graduates in Scotland.

Exploring what Student Engagement means for Biology Educators: What can Gamification Research tell us? (2023)
Presentation / Conference Contribution
Garden, C. L. P. (2023, July). Exploring what Student Engagement means for Biology Educators: What can Gamification Research tell us?. Presented at Society for Experimental Biology Centenary Conference, Edinburgh

The way we teach experimental biology continues to change as we recover, and learn lessons, from the COVID-19 pandemic. We often discuss student engagement as part of this process, but what does this mean in practice? How can we tell if students are... Read More about Exploring what Student Engagement means for Biology Educators: What can Gamification Research tell us?.

Assessment of 3-Nitrooxypropanol “3-NOP” as a feed additive for all ruminants for milk production and reproduction. (2023)
Report
Morrison, D. (2023). Assessment of 3-Nitrooxypropanol “3-NOP” as a feed additive for all ruminants for milk production and reproduction. Food Standards Agency

A request was received to provide a full risk assessment on the safety and efficacy of an additive (Bovaer ® 10) containing a minimum 10% 3-nitrooxypropanol, under Regulation (EC) No 1831/20031 under the category of ‘zootechnical’ additives, function... Read More about Assessment of 3-Nitrooxypropanol “3-NOP” as a feed additive for all ruminants for milk production and reproduction..

Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq (2023)
Journal Article
Stokes, T., Cen, H. H., Kapranov, P., Gallagher, I. J., Pitsillides, A. A., Volmar, C., Kraus, W. E., Johnson, J. D., Phillips, S. M., Wahlestedt, C., & Timmons, J. A. (2023). Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq. Advanced Genetics, 4(2), Article 2200024. https://doi.org/10.1002/ggn2.202200024

Sequencing the human genome empowers translational medicine, facilitating transcriptome-wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short-read RNA sequenc... Read More about Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq.

Using immersive tech to enrich healthcare education (2022)
Digital Artefact
McKenzie, C., Skinner, J., & Poole, A. Using immersive tech to enrich healthcare education. [Article]

As virtual reality technology has become more affordable and user friendly, it opens opportunities to enhance teaching of clinical skills. Here’s how one team brings VR into the classroom

Resilience, anxiety and depression in nurses working in respiratory areas during the COVID-19 pandemic (2021)
Presentation / Conference Contribution
Roberts, N. J., McAlooney-Kocaman, K., Welch, L., Ray, E., Lippiett, K., & Kelly, C. (2021). Resilience, anxiety and depression in nurses working in respiratory areas during the COVID-19 pandemic. Thorax, 76(suppl 1), A70

Nurses who work with respiratory patients, have been at the forefront of the pandemic response. Lessons need to be learnt from these nurses’ experiences in order to support these nurses during the existing pandemic and retain and mobilise this skille... Read More about Resilience, anxiety and depression in nurses working in respiratory areas during the COVID-19 pandemic.

Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2020 (2021)
Report
Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2020. Antimicrobial Resistance and Healthcare Associated Infection Scotland

A 'One Health' approach to tackling AMR was adopted in Scotland in 2016 and acknowledges that the health of humans, animals and the environment are interconnected. Antimicrobial use and spread of infection in humans, animals and the environment contr... Read More about Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2020.

Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2019 (2021)
Report
Morrison, D. Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2019. Antimicrobial Resistance and Healthcare Associated Infection Scotland

An unplanned revision has been undertaken and corrections to figures and messages have been highlighted in red. Updates have also been made to the Animal Antimicrobial Use and Minimising the spread of AMR through the environment sections. Antimicrobi... Read More about Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2019.