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Outputs (73)

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise (2008)
Journal Article
Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2008). Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain, Behavior, and Immunity, 22(4), 544-551. https://doi.org/10.1016/j.bbi.2007.11.002

Senescent T-lymphocytes are antigen-experienced cells that express the killer-cell lectin-like receptor G1 (KLRG1) and/or CD57; fail to clonally expand following further antigenic stimulation and prevail in the resting blood of older adults compared... Read More about Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise.

Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation (2007)
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007). Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012

Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals can potentiate the ability of nanoparticles to induce lung inflammation and... Read More about Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation.

Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. (2007)
Journal Article
Lin, Y., Stevens, C., & Hupp, T. (2007). Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. Journal of Biological Chemistry, 282(23), 16792-16802. https://doi.org/10.1074/jbc.M611559200

DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 protein regulation, we have determined that DAPK-1 protein has a long half-life... Read More about Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis..

A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis (2007)
Journal Article
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., Durston, V., Eccles, D. M., & Hupp, T. (2007). A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry, 282(18), 13791-13803. https://doi.org/10.1074/jbc.m605649200

p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the mechanism of DAPK-1 control, a novel mutation (N1347S) was identified in the... Read More about A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis.

Nanoparticle and metal interactions and their impact on lung toxicology (2005)
Presentation / Conference Contribution
Wilson, M. R., Barlow, P. G., Hutchison, G. R., Guy, K., Griffiths, A., Simpson, R. J., Sales, J., & Stone, V. (2005, April). Nanoparticle and metal interactions and their impact on lung toxicology. Presented at W22 48-50. IEH 9th Annual Review of Air Pollution Research

No abstract available.

Lymphocyte Apoptosis, Adhesion/activation Molecules And Complement Regulatory Proteins Following Intensive, Moderate And Eccentric Exercise: 1739 11:30 AM - 11:45 AM (2005)
Journal Article
Simpson, R. J., Guy, K., Whyte, G. P., & Florida-James, G. D. (2005). Lymphocyte Apoptosis, Adhesion/activation Molecules And Complement Regulatory Proteins Following Intensive, Moderate And Eccentric Exercise: 1739 11:30 AM - 11:45 AM. Medicine and Science in Sports and Exercise, 37(Supplement), S336. https://doi.org/10.1097/00005768-200505001-01738

No abstract available.

Pro-inflammatory interactions between particles, metals and lung cells (2004)
Presentation / Conference Contribution
Donaldson, K., Hibbs, L., Heal, M., Tran, C. L., Lightbody, J., Barlow, P. G., Hutchison, G., Brown, D. M., & Stone, V. (2003, June). Pro-inflammatory interactions between particles, metals and lung cells. Presented at INIS 9th International Inhalation Symposium

No abstract available.

Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration (2004)
Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005). Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.11.006

Objective:
To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a model previously reported to investigate complement activation by other respir... Read More about Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration.

The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung (2004)
Thesis
Barlow, P. G. The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/1052591

The effects of inhaled aIr pollution particles on lung clearance mechanisms is an important factor in understanding how the mammalian lung deals with such pollutants and, as such, how exposure to these pollutants can be regulated. The nanoparticle
(... Read More about The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung.

Chk2 activates E2F-1 in response to DNA damage (2003)
Journal Article
Stevens, C., Smith, L., & La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409. https://doi.org/10.1038/ncb974

The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. A Chk2 c... Read More about Chk2 activates E2F-1 in response to DNA damage.

Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence (2002)
Journal Article
Taylor, C. M., Beresford, M., Epton, H. A. S., Sigee, D. C., Shama, G., Andrew, P. W., & Roberts, I. S. (2002). Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence. Journal of Bacteriology, 184(3), 621-628. https://doi.org/10.1128/JB.184.3.621-628.2002

We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth after attachment to a model surface. Both mutants were unable to accumulate (p)... Read More about Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence.