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Dr Donald Morrison's Outputs (78)

Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria (2024)
Journal Article
Surendran, A., Turnbull, A., Flockhart, A., Findlay-Greene, F., Nowosielska, M., Morrison, D., Mincher, D. J., & Donnellan, S. (2024). Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria. All Life, 17(1), Article 2379309. https://doi.org/10.1080/26895293.2024.2379309

We hypothesise that antimicrobial resistance (AMR) cannot be overcome by simply ‘drugging’ single biological targets, therefore, our focus is developing broad-spectrum therapeutics. Herein we present the synthesis of two novel spacer-linked, anthraqu... Read More about Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria.

Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360) (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360). Food Standards Agency

An application was submitted to the Food Standards Agency in March 2021 from DSM Nutritional Products LTD (“the applicant”) for the new authorisation of an additive (ProAct 360) containing protease (subtilisin), under the category of “zootechnical ad... Read More about Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360).

Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®) (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®). Food Standards Agency

An application was submitted to the Food Standards Agency in April 2021 from Phibro Animal Health Corporation (“the applicant”) for the new authorisation of an additive (Magni-Phi®), a natural preparation of powdered dry Quillaja saponaria and dry Yu... Read More about Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®).

Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species. Food Standards Agency

An application was submitted to the Food Standards Agency in May 2021 from AlzChem Trostberg GmbH (“the applicant”) for the new use authorisation of an additive guanidinoacetic acid (Creamino®), under the category of ‘nutritional additives” and funct... Read More about Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species.

Literature Review on Antimicrobial Resistance In Relation To The Environment In Scotland (2024)
Report
Wojcik, G., Anderson, L., Johnston, L., Moffat, S., & Morrison, D. (2024). Literature Review on Antimicrobial Resistance In Relation To The Environment In Scotland. Environmental Standards Scotland

Commissioned literature review on the key causes, impacts and controls for anti-microbial resistance (AMR) in the environment that are relevant to Scotland. The review summarises what is currently known about the impact of AMR on the environment and... Read More about Literature Review on Antimicrobial Resistance In Relation To The Environment In Scotland.

Safety Assessment RP416 Axtra XB (2023)
Report
Morrison, D. (2023). Safety Assessment RP416 Axtra XB. Food Standards Agency

An application was submitted to the Food Standards Agency in February 2021 by Genencor International B.V. (“the applicant”) for the authorisation of an additive (endo-1,4-betaxylanase and endo-1,3(4)-beta-glucanase - Axtra® XB), under retained regula... Read More about Safety Assessment RP416 Axtra XB.

UK One Health Report: Joint report on antibiotic use, antibiotic sales and antibiotic resistance (2023)
Report
Veterinary Medicines Directorate, & UK Health Security Agency. (2023). UK One Health Report: Joint report on antibiotic use, antibiotic sales and antibiotic resistance. UK Government

The third publication of the One Health Report brings together antibiotic resistance and consumption data from humans and animals, combined with data on antibiotic resistance in food and antimicrobial substances in the environment.

The data presen... Read More about UK One Health Report: Joint report on antibiotic use, antibiotic sales and antibiotic resistance.

Assessment of 3-Nitrooxypropanol “3-NOP” as a feed additive for all ruminants for milk production and reproduction. (2023)
Report
Morrison, D. (2023). Assessment of 3-Nitrooxypropanol “3-NOP” as a feed additive for all ruminants for milk production and reproduction. Food Standards Agency

A request was received to provide a full risk assessment on the safety and efficacy of an additive (Bovaer ® 10) containing a minimum 10% 3-nitrooxypropanol, under Regulation (EC) No 1831/20031 under the category of ‘zootechnical’ additives, function... Read More about Assessment of 3-Nitrooxypropanol “3-NOP” as a feed additive for all ruminants for milk production and reproduction..

Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2020 (2021)
Report
Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2020. Antimicrobial Resistance and Healthcare Associated Infection Scotland

A 'One Health' approach to tackling AMR was adopted in Scotland in 2016 and acknowledges that the health of humans, animals and the environment are interconnected. Antimicrobial use and spread of infection in humans, animals and the environment contr... Read More about Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2020.

Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2019 (2021)
Report
Morrison, D. Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2019. Antimicrobial Resistance and Healthcare Associated Infection Scotland

An unplanned revision has been undertaken and corrections to figures and messages have been highlighted in red. Updates have also been made to the Animal Antimicrobial Use and Minimising the spread of AMR through the environment sections. Antimicrobi... Read More about Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2019.

A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants (2020)
Journal Article
Marano, R. B., Fernandes, T., Manaia, C. M., Nunes, O., Morrison, D., Berendonk, T. U., Kreuzinger, N., Telson, T., Corno, G., Fatta-Kassinos, D., Merlin, C., Topp, E., Jurkevitch, E., Henn, L., Scott, A., Heß, S., Slipko, K., Laht, M., Kisand, V., Di Cesare, A., …Cytryn, E. (2020). A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants. Environment International, 144, Article 106035. https://doi.org/10.1016/j.envint.2020.106035

The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings... Read More about A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants.

Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2018 (2019)
Report
Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2018. Health Protection Scotland (HPS)

Antimicrobial resistance (AMR) remains a major public health issue. AMR occurs when microorganisms, such as bacteria, adapt to survive exposure to a treatment that would normally kill them. Inappropriate and unnecessary antibiotic use speeds up the d... Read More about Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2018.

Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing (2019)
Journal Article
Dancer, S. J., Adams, C. E., Smith, J., Pichon, B., Kearns, A., & Morrison, D. (2019). Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing. Journal of Hospital Infection, 103(1), 13-20. https://doi.org/10.1016/j.jhin.2019.04.016

Background: Staphylococcus aureus remains an important bacterial pathogen worldwide. This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one ten-bed intensive care unit (ICU).

Methods... Read More about Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing.

Typing of methicillin resistant and sensitive Staphylococcus aureus isolated from Tamilnadu, India using DNA fingerprints by pulsed-field gel electrophoresis (2014)
Journal Article
Rajaduraipandi, K., Morrison, D., Mani, M., Nambirajan, G., Panneerselvam, K., Shobana, S., Narendran, V., & Manikandan, P. (2014). Typing of methicillin resistant and sensitive Staphylococcus aureus isolated from Tamilnadu, India using DNA fingerprints by pulsed-field gel electrophoresis. Acta Biologica Szegediens, 58(2), 171-177

MRSA infection is alarming particularly in hospital set ups/community. We typed 43 isolates of Staphylococcus aureus (MRSA and MSSA) based on genomic DNA restriction fragment length polymorphisms (RFLPs). The genomic DNA of the test isolates was dige... Read More about Typing of methicillin resistant and sensitive Staphylococcus aureus isolated from Tamilnadu, India using DNA fingerprints by pulsed-field gel electrophoresis.

The Enterococci (2014)
Book Chapter
Heimer, S. R., Morrison, D., & Gilmore, M. S. (2014). The Enterococci. In Y.-W. Tang, M. Sussman, D. Liu, & I. Poxton (Eds.), Molecular Medical Microbiology (717-730). (2nd revised). Academic Press

No abstract available.

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in Poland: further evidence for the changing epidemiology of MRSA. (2008)
Journal Article
Bogut, A., Kozioł-Montewka, M., Baranowicz, I., Józ’wiak, L., Al-Doori, Z., Morrison, D., Kaczor, D., & Ksia˛z’ek, A. (2008). of MRSA. The new microbiologica, 31, 229-234

This study reports the isolation of CA-MRSA strain which was found to colonize the nasal mucosa of a patient undergoing haemodialysis treatment. The MRSA was subjected to molecular analysis by Pulsed Field Gel Electrophoresis (PFGE), multiplex PCR as... Read More about Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in Poland: further evidence for the changing epidemiology of MRSA..

Usefulness of mec-associated direct repeat unit (dru) typing in the epidemiological analysis of highly clonal methicillin-resistant Staphylococcus aureus in Scotland (2008)
Journal Article
Goering, R., Morrison, D., Al-Doori, Z., Edwards, G., & Gemmell, C. (2008). Usefulness of mec-associated direct repeat unit (dru) typing in the epidemiological analysis of highly clonal methicillin-resistant Staphylococcus aureus in Scotland. Clinical Microbiology and Infection, 14(10), 964-969. https://doi.org/10.1111/j.1469-0691.2008.02073.x

The incidence of the epidemic methicillin-resistant Staphylococcus aureus (EMRSA) strains EMRSA-15 and EMRSA-16 in Scotland has increased dramatically, now accounting for c. 70% and c. 20% of isolates, respectively. Epidemiological tracking of these... Read More about Usefulness of mec-associated direct repeat unit (dru) typing in the epidemiological analysis of highly clonal methicillin-resistant Staphylococcus aureus in Scotland.

A European laboratory network for sequence-based typing of methicillin-resistant Staphylococcus Aureus (MRSA) as a communication platform between human and veterinary medicine - an update on SeqNet.org (2008)
Journal Article
Friedrich, A. W., Witte, W., De Lencastre, H., Hryniewicz, W., Scheres, J., Westh, H., & SeqNet.Org participants. (2008). A European laboratory network for sequence-based typing of methicillin-resistant Staphylococcus Aureus (MRSA) as a communication platform between human and veterinary medicine - an update on SeqNet.org. Eurosurveillance, 13(4-6), https://doi.org/10.2807/ese.13.19.18862-en

No abstract available.

Detection of meticillin-resistant Staphylococcus aureus and Panton-Valentine leukocidin directly from clinical samples and the development of a multiplex assay using real-time polymerase chain reaction (2008)
Journal Article
Renwick, L., Hardie, A., Girvan, E. K., Smith, M., Leadbetter, G., Claas, E., Morrison, D., Gibb, A. P., Dave, J., & Templeton, K. E. (2008). Detection of meticillin-resistant Staphylococcus aureus and Panton-Valentine leukocidin directly from clinical samples and the development of a multiplex assay using real-time polymerase chain reaction. European Journal of Clinical Microbiology and Infectious Diseases, 27(9), 791-796. https://doi.org/10.1007/s10096-008-0503-9

Meticillin-resistant Staphylococcus aureus (MRSA) is a major pathogen responsible for significant numbers of healthcare-associated infections and isolates containing Panton-Valentine leukocidin (PVL) that cause severe skin infections are emerging as... Read More about Detection of meticillin-resistant Staphylococcus aureus and Panton-Valentine leukocidin directly from clinical samples and the development of a multiplex assay using real-time polymerase chain reaction.