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Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing

Dancer, Stephanie J.; Adams, Claire E.; Smith, Jennifer; Pichon, Bruno; Kearns, Angela; Morrison, Donald


Claire E. Adams

Jennifer Smith

Bruno Pichon

Angela Kearns


Background: Staphylococcus aureus remains an important bacterial pathogen worldwide. This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one ten-bed intensive care unit (ICU).

Methods: Selected hand-touch surfaces, staff hands and air were systematically screened ten times during ten months, with patients screened throughout the study. S. aureus isolates were subjected to spa typing and epidemiological analyses, followed by wholegenome sequencing (WGS) to provide single nucleotide polymorphism (SNP) data.

Results: Multiple transmission pathways between patients and reservoirs were investigated. There were 34 transmission events, of which 29 were highly related (

Journal Article Type Article
Acceptance Date Apr 22, 2019
Online Publication Date Apr 27, 2019
Publication Date 2019-09
Deposit Date May 1, 2019
Publicly Available Date Apr 28, 2020
Journal Journal of Hospital Infection
Print ISSN 0195-6701
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 103
Issue 1
Pages 13-20
Keywords Microbiology (medical); Infectious Diseases; General Medicine
Public URL
Contract Date Jul 8, 2019


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