Outputs (3)

A New Role for E2F-1 in Checkpoint Control (2003)
Journal Article
Stevens, C., & Thangue, N. B. L. (2003). A New Role for E2F-1 in Checkpoint Control. Cell Cycle, 2(5), 434-436. https://doi.org/10.4161/cc.2.5.462

In response to DNA damage, E2F-1 is induced and phosphorylated. Phosphorylated E2F-1 can reside in discrete nuclear structures and induce apoptosis, suggesting a unique role for E2F-1 in DNA repair and checkpoint functions.

Chk2 activates E2F-1 in response to DNA damage (2003)
Journal Article
Stevens, C., Smith, L., & La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409. https://doi.org/10.1038/ncb974

The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. A Chk2 c... Read More about Chk2 activates E2F-1 in response to DNA damage.

E2F and cell cycle control: a double-edged sword (2003)
Journal Article
Stevens, C., & La Thangue, N. B. (2003). E2F and cell cycle control: a double-edged sword. Archives of Biochemistry and Biophysics, 412(2), 157-169. https://doi.org/10.1016/s0003-9861%2803%2900054-7

The E2F family of transcription factors plays a central role in regulating cellular proliferation by controlling the expression of both the genes required for cell cycle progression, particularly DNA synthesis, and the genes involved with apoptosis.... Read More about E2F and cell cycle control: a double-edged sword.