A New Role for E2F-1 in Checkpoint Control

Stevens, Craig; Thangue, Nicholas B. La

Abstract

In response to DNA damage, E2F-1 is induced and phosphorylated. Phosphorylated E2F-1 can reside in discrete nuclear structures and induce apoptosis, suggesting a unique role for E2F-1 in DNA repair and checkpoint functions.

• Journal Article Type: Article
• Acceptance Date: Sep 12, 2003
• Online Publication Date: Jun 12, 2003
• Publication Date: Sep 12, 2003
• Deposit Date: Aug 5, 2016
• Journal: Cell Cycle
• Print ISSN: 1538-4101
• Electronic ISSN: 1551-4005
• Publisher: Taylor & Francis
• Peer Reviewed: Peer Reviewed
• Volume: 2
• Issue: 5
• Pages: 434-436
• DOI: https://doi.org/10.4161/cc.2.5.462
• Keywords: Developmental Biology; Cell Biology; Molecular Biology
• Public URL: http://researchrepository.napier.ac.uk/Output/327826