Dr Craig Stevens' Projects (6)

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease Oct 1, 2019 - Dec 31, 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the immune system to reduce inflammation and induce remi... Read More about Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease.

Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection Apr 1, 2019 - Mar 31, 2022
A significant challenge faced by modern society is the lack of therapeutics for a large number of infections, particularly those that are endemic or widely spread in developing countries. Dengue is one such infection which is endemic inIndonesia - it... Read More about Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection.

IBD drug effect on autophagy (IDEA) Oct 1, 2017 - Mar 31, 2018
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD

Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis Sep 1, 2018 - Apr 30, 2023
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately produces pain and the impairment of normal activities... Read More about Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis.

An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD Sep 1, 2014 - Aug 31, 2017
Recent genetic discoveries, principally identification of NOD2 and ATG16L1 as susceptibility loci, strongly implicate a dysregulated host response to enteric bacteria and the autophagy pathway in the pathogenesis of Crohn’s disease (CD). Several micr... Read More about An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD.

Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection May 1, 2015 - Jun 30, 2017
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a potential host defence mechanism. We propose to c... Read More about Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection.