Outputs (5)

Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer (2016)
Presentation / Conference Contribution
Mathur, S., Mincher, D., Turnbull, A., Stevens, C., & Poole, A. (2016). Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer. European Journal of Cancer, 61, S142. https://doi.org/10.1016/s0959-8049%2816%2961501-0

Background: In spite of major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection. Legumain is a potential cancer biomarker and a molecular target for imaging and drug targeting. Legumain is a... Read More about Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer.

Inflammatory Bowel Disease Drugs: A Focus on Autophagy (2016)
Journal Article
Hooper, K. M., Barlow, P. G., Stevens, C., & Henderson, P. (2017). Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis, 11(1), 118-127. https://doi.org/10.1093/ecco-jcc/jjw127

Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and biologic agents are used to induce and maintain remission; however, respon... Read More about Inflammatory Bowel Disease Drugs: A Focus on Autophagy.

Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections (2016)
Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016). Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036

Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antiviral, and immunomodulatory activities. They can contribute to the rapid clear... Read More about Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections.

Antiviral host defence peptides. (2016)
Book Chapter
Sousa, F. H., Casanova, V., Stevens, C., & Barlow, P. G. (2016). Antiviral host defence peptides. In R. M. Epand (Ed.), Host Defense Peptides and Their Potential as Therapeutic Agents (57-94). Springer. https://doi.org/10.1007/978-3-319-32949-9_3

The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The antiviral activity of cationic host defence peptides is of significant interest... Read More about Antiviral host defence peptides..

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (2016)
Journal Article
Baghdiguian, S., Bagniewska-Zadworna, A., Baek, S., Baehrecke, E. H., Bae, S. H., Bae, D., Bae, J., Backer, J. M., Azad, N., Bachetti, T., Awale, S., Avantaggiati, M. L., Avrahami, L., Avagliano, L., Autelli, R., Auburger, G., Aurelian, L., Auberger, P., Attardi, L. D., Atherton, S. S., …Stevens, C. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222. https://doi.org/10.1080/15548627.2015.1100356

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies... Read More about Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)..