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The combined use of biological investigations, bio chromatographic and in silico methods to solve the puzzle of badge and its derivative's toxicity (2024)
Journal Article
Neri, I., Piccolo, M., Russo, G., Ferraro, M. G., Marotta, V., Santamaria, R., & Grumetto, L. (2024). The combined use of biological investigations, bio chromatographic and in silico methods to solve the puzzle of badge and its derivative's toxicity. Chemosphere, 367, Article 143640. https://doi.org/10.1016/j.chemosphere.2024.143640

Bisphenol A diglycidyl ether (BADGE) is a pre-polymer of BPA widely used in manufacturing of epoxy resins and plastics; due to its high reactivity, unintended by-products, such as chlorinated and hydrolysed products, can reach the human body. This re... Read More about The combined use of biological investigations, bio chromatographic and in silico methods to solve the puzzle of badge and its derivative's toxicity.

Development of an immobilised artificial membrane liquid chromatography-mass spectrometry-based platform for high throughput and reliable assessments of the pulmonary permeability of drugs (2024)
Presentation / Conference Contribution
Dillon, A., Orzel, D., Russo, G., & Wiedmer, S. (2024, October). Development of an immobilised artificial membrane liquid chromatography-mass spectrometry-based platform for high throughput and reliable assessments of the pulmonary permeability of drugs. Poster presented at 34th International Symposium of Chromatography - ISC2024, Liverpool, UK

Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa (2024)
Journal Article
Orzel, D., Ravald, H., Dillon, A., Rantala, J., Wiedmer, S. K., & Russo, G. (2024). Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa. Journal of Chromatography A, 1734, Article 465286. https://doi.org/10.1016/j.chroma.2024.465286

This study pioneers a comparison of the application of biomimetic techniques, immobilised artificial membrane liquid chromatography (IAM LC) and liposome electrokinetic capillary chromatography (LEKC), for the prediction of pulmonary drug permeabilit... Read More about Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa.

Immobilized Artificial Membrane Liquid Chromatography vs Liposome Electrokinetic Chromatography: suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of drugs’ passage through the respiratory mucosa (2024)
Presentation / Conference Contribution
Russo, G., Orzel, D., Dillon, A., Ravald, H., Rantala, J., & Wiedmer, S. K. (2024, October). Immobilized Artificial Membrane Liquid Chromatography vs Liposome Electrokinetic Chromatography: suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of drugs’ passage through the respiratory mucosa. Paper presented at 34th International Symposium on Chromatography – ISC 2024, Liverpool

The effectiveness of immobilised artificial membrane and liposome electrokinetic chromatography in predicting the pulmonary delivery of drugs in humans (2024)
Presentation / Conference Contribution
Orzel, D., Dillon, A., Russo, G., & Wiedmer, S. (2024, October). The effectiveness of immobilised artificial membrane and liposome electrokinetic chromatography in predicting the pulmonary delivery of drugs in humans. Poster presented at 34th International Symposium of Chromatography - ISC2024, Liverpool

Bisphenol A and its analogues: from their occurrence in foodstuffs marketed in Europe to improved monitoring strategies—a review of published literature from 2018 to 2023 (2024)
Journal Article
Neri, I., Russo, G., & Grumetto, L. (2024). Bisphenol A and its analogues: from their occurrence in foodstuffs marketed in Europe to improved monitoring strategies—a review of published literature from 2018 to 2023. Archives of Toxicology, 98(8), 2441-2461. https://doi.org/10.1007/s00204-024-03793-4

In this review article, the research works covering the analytical determination of bisphenol A (BPA) and its structural analogues published from 2018 to present (February 2024) were examined. The review offers an overview of the concentration levels... Read More about Bisphenol A and its analogues: from their occurrence in foodstuffs marketed in Europe to improved monitoring strategies—a review of published literature from 2018 to 2023.

Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions (2024)
Journal Article
Neri, I., MacCallum, J., Di Lorenzo, R., Russo, G., Lynen, F., & Grumetto, L. (2024). Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions. Science of the Total Environment, 917, Article 170461. https://doi.org/10.1016/j.scitotenv.2024.170461

Five parabens (PBs) i.e., Methylparaben (MP), Ethylparaben (EP), Isopropylparaben (iPrP), Isobutylparaben (iBuP), Benzylparaben (BzP), and their parent compound i.e., para–hydroxy Benzoic Acid (pHBA), were studied both in vitro and in silico. Specifi... Read More about Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions.

From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring? (2023)
Presentation / Conference Contribution
Russo, G. (2023, September). From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?. Presented at 10th IAPC Meeting, Belgrade, Serbia

Biomimetic chromatography encompasses a range of analytical approaches aimed at mimicking the asset of biological membranes including – but not limited to – micellar liquid chromatography (MLC), immobilized artificial membranes (IAM) and immobilize... Read More about From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?.

High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC (2023)
Journal Article
Russo, G., Kajtazi, A., Vallaro, M., Surmont, P., Ermondi, G., Anderson, S., Grumetto, L., Caron, G., & Lynen, F. (2023). High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC. Journal of Pharmaceutical and Biomedical Analysis, 235, Article 115604. https://doi.org/10.1016/j.jpba.2023.115604

The charge state of a molecule is the single most prominent attribute ruling out its interactions with the surrounding environment. In a previous study, the retention of acids on the new Celeris™ Arginine (ARG) column was found to b... Read More about High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC.

Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction (2023)
Journal Article
Kajtazi, A., Russo, G., Wicht, K., Eghbali, H., & Lynen, F. (2023). Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction. Chemosphere, 337, Article 139361. https://doi.org/10.1016/j.chemosphere.2023.139361

Implementing effective environmental management strategies requires a comprehensive understanding of the chemical composition of environmental pollutants, particularly in complex mixtures. Utilizing innovative analytical techniques, such as high-reso... Read More about Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction.

The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption (2023)
Presentation / Conference Contribution
Dillon, A., Orzek, D., MacCallum, J., & Russo, G. (2023, June). The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption. Poster presented at HPLC 2023

Nowadays immobilized artificial membranes (IAM) are commonly used for modelling drug
transport through biological lipid layers. In most published studies a compound’s lipophilicity
measurements are performed in isocratic conditions where a low pe... Read More about The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption.

Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors (2022)
Journal Article
Russo, G., Piccolo, M., Neri, I., Ferraro, M. G., Santamaria, R., & Grumetto, L. (2023). Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors. Chemosphere, 313, Article 137569. https://doi.org/10.1016/j.chemosphere.2022.137569

Endocrine disruptors are chemicals widely used worldwide by industries in a variety of applications. Routinely exposure to these chemicals, even if at low doses, can cause damage effects on human health. In the present study, we evaluated toxic effec... Read More about Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors.

Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients (2022)
Journal Article
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., Panariello, I., Rocco, D., Pezzullo, L., & Vitale, M. (2023). Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients. Environmental Pollution, 316, Article 120478. https://doi.org/10.1016/j.envpol.2022.120478

Bisphenol A (BPA) is a widespread thyroid disruptor, but evidence about an association with thyroid cancer is weak. Excess body weight is a risk factor for thyroid cancer and affects activity of endocrine disruptors. Aim of the study was to investiga... Read More about Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients.

Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers (2022)
Journal Article
Di Lorenzo, R., Neri, I., Russo, G., Laneri, S., & Grumetto, L. (2022). Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers. Cosmetics, 9(5), Article 102. https://doi.org/10.3390/cosmetics9050102

A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also... Read More about Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers.

Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography (2022)
Journal Article
Neri, I., Laneri, S., Di Lorenzo, R., Dini, I., Russo, G., & Grumetto, L. (2022). Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography. Molecules, 27(13), Article 4263. https://doi.org/10.3390/molecules27134263

Parabens (PBs) are used as preservatives to extend the shelf life of various foodstuffs, and pharmaceutical and cosmetic preparations. In this work, the membrane barrier passage potential of a subset of seven parabens, i.e., methyl-, ethyl-, propyl-... Read More about Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography.

Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy (2022)
Journal Article
Russo, G., Laneri, S., Di Lorenzo, R., Neri, I., Dini, I., Ciampaglia, R., & Grumetto, L. (2022). Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy. Molecules, 27(13), Article 3990. https://doi.org/10.3390/molecules27133990

The concentration levels of thirteen organic pollutants and selected heavy metals were investigated in 40 plastics bottled and tap water samples. Some of the selected contaminants have an ascertained or suspected endocrine disrupting activity, such a... Read More about Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy.

De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater (2022)
Presentation / Conference Contribution
Kajtazi, G., Wicht, K., Russo, G., Eghbali, H., & Lynen, F. (2022, May). De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater. Poster presented at 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium

Micropollutants, such as pharmaceuticals, industrial chemicals, steroid hormones, etc. are defined as anthropogenic chemicals and can be found in water. It is seen as a serious threat, not just to aquatic life but also to humans, which requires the a... Read More about De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater.