Outputs (18)

Therapeutic potential of Tregs to treat rheumatoid arthritis (2011)
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there ar... Read More about Therapeutic potential of Tregs to treat rheumatoid arthritis.

Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies (2011)
Journal Article
Kinloch, A. J., Ng, K., & Wright, G. P. (2011). Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies. Recent patents on inflammation & allergy drug discovery, 5(2), 108-127. https://doi.org/10.2174/187221311795399246

Rheumatoid arthritis (RA), although widely considered to be the most commonly occurring autoimmune disease, has only truly been substantiated as a distinct autoimmune disease very recently. The lack of understanding of the specific autoimmune system/... Read More about Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies.

Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity (2011)
Journal Article
Wright, G. P., Ehrenstein, M. R., & Stauss, H. J. (2011). Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity. Expert Review of Clinical Immunology, 7(2), 213-225. https://doi.org/10.1586/eci.10.96

Tregs have shown considerable potential in treating preclinical models of autoimmunity. These studies have highlighted the importance of Treg antigen (Ag) specificity. Translation of these promising results to the clinic will require a robust method... Read More about Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity.

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells (2011)
Journal Article
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8), 4967-4972. https://doi.org/10.4049/jimmunol.1003021

The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in the removal of apoptotic cells, we investigated whether the immune modulator... Read More about Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells.

Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation (2010)
Book Chapter
Ghorashian, S., Wright, G., Thomas, S., Hart, D. P., King, J., Voisine, C., Pospori, C., Perro, M., Cesco-Gaspere, M., Holler, A., Gao, L., Xue, S.-A., Morris, E. C., Chakraverty, R., & Stuass, H. J. (2010). Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation. In Y. Reisner, & M. F. Martelli (Eds.), Bone Marrow Transplantation Across Major Genetic Barriers (373-395). World Scientific. https://doi.org/10.1142/9789814271271_0016

Allogeneic hematopoietic stem cell transplantation (HSCT) is carried out to correct genetic disorders of the hematopoietic system, as well as to treat hematopoietic malignancies. Adoptive Tcell therapy has great potential as an adjunct to this treatm... Read More about Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation.

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis (2009)
Journal Article
Wright, G. P., Notley, C. A., Xue, S. A., Bendle, G. M., Holler, A., Schumacher, T. N., Ehrenstein, M. R., & Stauss, H. J. (2009). Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences, 106(45), 19078-19083. https://doi.org/10.1073/pnas.0907396106

Regulatory T cells (Tregs) can suppress a wide range of immune cells, making them an ideal candidate for the treatment of autoimmunity. The potential clinical translation of targeted therapy with antigen-specific Tregs is hampered by the difficulties... Read More about Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis.

Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy (2007)
Journal Article
Stauss, H. J., Cesco-Gaspere, M., Thomas, S., Hart, D. P., Xue, S.-A., Holler, A., Wright, G., Perro, M., Little, A.-M., Pospori, C., King, J., & Morris, E. C. (2007). Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy. Molecular Therapy, 15(10), 1744-1750. https://doi.org/10.1038/sj.mt.6300216

Adoptive transfer of antigen-specific T lymphocytes is an effective form of immunotherapy for persistent virus infections and cancer. A major limitation of adoptive therapy is the inability to isolate antigen-specific T lymphocytes reproducibly. The... Read More about Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy.

WT1-specific T cell receptor gene therapy: Improving TCR function in transduced T cells (2007)
Journal Article
Stauss, H. J., Thomas, S., Cesco-Gaspere, M., Hart, D. P., Xue, S.-A., Holler, A., King, J., Wright, G., Perro, M., Pospori, C., & Morris, E. (2008). WT1-specific T cell receptor gene therapy: Improving TCR function in transduced T cells. Blood Cells, Molecules and Diseases, 40(1), 113-116. https://doi.org/10.1016/j.bcmd.2007.06.018

Adoptive transfer of antigen-specific T lymphocytes is an attractive form of immunotherapy for haematological malignancies and cancer. The difficulty of isolating antigen-specific T lymphocytes for individual patients limits the more widespread use o... Read More about WT1-specific T cell receptor gene therapy: Improving TCR function in transduced T cells.