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Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit (2001)
Journal Article
Forster, I. C., Harvey, R. J., Darlison, M. G., & Benson, J. A. (2001). Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit. European Journal of Pharmacology, 419(1), 1-7. https://doi.org/10.1016/S0014-2999%2801%2900964-5

The functional pharmacology of receptors composed of the chicken brain {GABAA} receptor γ4 subunit and the mammalian {GABAA} receptor α3 and β2 subunits was studied by heterologous expression in Xenopus laevis oocytes using the two electrode voltage-... Read More about Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit.

Host Attitudes towards Guests in the Homestay Sector (1999)
Journal Article
Lynch, P. A. (1999). Host Attitudes towards Guests in the Homestay Sector. Tourism and Hospitality Research, 1(2), 119-144. https://doi.org/10.1177/146735849900100203

This paper reports on an investigation into host attitudes towards guests in one segment of the homestay accommodation sector: host families. In addition to discussion of the main characteristics of hostfamilies, host attitudes to guests are examined... Read More about Host Attitudes towards Guests in the Homestay Sector.

In Situ Hybridization Localization of the GABAA Receptor β2S- and β2L-Subunit Transcripts Reveals Cell-Specific Splicing of Alternate Cassette Exons (1997)
Journal Article
Harvey, R., & Darlison, M. (1997). In Situ Hybridization Localization of the GABAA Receptor β2S- and β2L-Subunit Transcripts Reveals Cell-Specific Splicing of Alternate Cassette Exons. Neuroscience, 77(2), 361-369. https://doi.org/10.1016/S0306-4522%2896%2900467-8

We have recently described two variants of the chicken {GABAA} receptor β2 subunit which arise by alternative splicing of the corresponding primary gene transcript. The long form of the β2 subunit (β2L) differs from the short form (β2S) by the insert... Read More about In Situ Hybridization Localization of the GABAA Receptor β2S- and β2L-Subunit Transcripts Reveals Cell-Specific Splicing of Alternate Cassette Exons.

Provider‐related barriers and enablers to the provision of hepatitis C treatment by General Practitioners in Scotland: A behaviour change analysis (2020)
Journal Article
Whiteley, D., Speakman, E., Elliott, L., Davidson, K., Hamilton, E., Jarvis, H., Quinn, M., & Flowers, P. (2021). Provider‐related barriers and enablers to the provision of hepatitis C treatment by General Practitioners in Scotland: A behaviour change analysis. Journal of Viral Hepatitis, 28(3), 528-537. https://doi.org/10.1111/jvh.13443

The ease of Direct Acting Antiviral (DAA) medications for hepatitis C virus (HCV) has provided an opportunity to decentralise HCV treatment into community settings. However, the role of non-specialist clinicians in community-based pathways has recei... Read More about Provider‐related barriers and enablers to the provision of hepatitis C treatment by General Practitioners in Scotland: A behaviour change analysis.

Candidate gene study of eight GABAA receptor subunits in panic disorder (1997)
Journal Article
Darlison, M. G., Bailey, M., Johnson, K., Wang, Z., Crowe, R., Albrecht, B., Noyes, J. R., & Zoega, T. (1997). Candidate gene study of eight GABAA receptor subunits in panic disorder. American Journal of Psychiatry, 154(8), 1096-1100. https://doi.org/10.1176/ajp.154.8.1096

OBJECTIVE: gamma-Aminobutyric acid type A (GABAA) receptor subunit genes are candidate genes for panic disorder. Benzodiazepine agonists acting at this receptor can suppress panic attacks, and both inverse agonists and antagonists can precipitate th... Read More about Candidate gene study of eight GABAA receptor subunits in panic disorder.

Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes (1998)
Journal Article
Liu, S., Parent, L., Harvey, R. J., Darlison, M. G., & Eugene, J. M. B. (1998). Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes. European Journal of Pharmacology, 354(2-3), 253-259. https://doi.org/10.1016/S0014-2999%2898%2900453-1

Chicken {GABAA} receptor β4L and β4S subunits were expressed in Xenopus oocytes by cRNA injection. Oocytes expressing either β4 subunit alone or in combination with the chicken α1 subunit were studied using the two-electrode voltage-clamp technique.... Read More about Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes.

Reliable and accurate sequencing of lambda, cosmid and P1 DNAs using modified dye terminator reaction parameters (1998)
Journal Article
Harvey, R. J., Harder, S., & Darlison, M. G. (1998). Reliable and accurate sequencing of lambda, cosmid and P1 DNAs using modified dye terminator reaction parameters. Technical tips online, 3(1), 150-152. https://doi.org/10.1016/S1366-2120%2808%2970126-0

Many laboratories still find the direct sequencing of large DNA templates (i.e. lambda, cosmid and bacteriophage P1 clones) problematic. To date, only limited amounts of sequence information, which in many cases is of poor quality, can be generated f... Read More about Reliable and accurate sequencing of lambda, cosmid and P1 DNAs using modified dye terminator reaction parameters.

Multiple genes for neuropeptides and their receptors: co-evolution and physiology (1999)
Journal Article
Darlison, M. G., & Richter, D. (1999). Multiple genes for neuropeptides and their receptors: co-evolution and physiology. Trends in Neurosciences, 22(2), 81-88. https://doi.org/10.1016/S0166-2236%2898%2901333-2

It is now well established that neuropeptide receptors, which are present throughout the {CNS} and in peripheral tissues, frequently exist in a variety of different forms (called subtypes), each of which is encoded by a distinct gene. With the recent... Read More about Multiple genes for neuropeptides and their receptors: co-evolution and physiology.

Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3 (1999)
Journal Article
Bailey, M. E., Albrecht, B. E., Johnson, K. J., & Darlison, M. G. (1999). Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. BBA - Gene Structure and Expression, 1447(2-3), 307-312. https://doi.org/10.1016/s0167-4781%2899%2900167-0

{GABAC} receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: ρ1 (GABRR1), ρ2 (GABRR2) and ρ3 (GABRR3). We show that {GABRR1} and {G... Read More about Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3.

Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity (2007)
Journal Article
Fraser, J. A., & Hupp, T. R. (2007). Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity. Biochemistry, 46(10), 2655-2673. https://doi.org/10.1021/bi061562j

Dissection of signal transduction pathways has been advanced by classic genetic approaches including targeted gene deletion and siRNA-based inhibition of gene product synthesis. Chemical genetics is a biochemical approach to develop small peptide-mim... Read More about Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity.

Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish (2001)
Journal Article
Pohl, S., Darlison, M. G., Clarke, W., Lederis, K., & Richter, D. (2001). Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish. European Journal of Pharmacology, 430(2-3), 193-202. https://doi.org/10.1016/S0014-2999%2801%2901391-7

Although it is well established that fish possess corticotropin-releasing factor (CRF) and a CRF-like peptide, urotensin I, comparatively little is known about the pharmacology of their cognate receptors. Here we report the isolation and functional e... Read More about Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish.

The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus (2004)
Journal Article
Thode, C., Bock, J., Braun, K., & Darlison, M. (2005). The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus. Neuroscience, 130(3), 611-617. https://doi.org/10.1016/j.neuroscience.2004.10.015

The immediate-early gene zenk (an acronym for the avian orthologue of the mammalian genes zif-268, egr-1, ngfi-a and krox-24) has been extensively employed, in studies on oscine birds, as a marker of neuronal activity to reveal forebrain structures t... Read More about The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus.

Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick (2005)
Journal Article
Bock, J., Thode, C., Hannemann, O., Braun, K., & Darlison, M. (2005). Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick. Neuroscience, 133(3), 625-633. https://doi.org/10.1016/j.neuroscience.2005.02.048

We have cloned a full-length complementary {DNA} from the chicken (Gallus gallus domesticus), which encodes a polypeptide that exhibits ∼75% identity to the product of the mammalian gene Arc (activity-regulated cytoskeleton-associated protein), also... Read More about Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick.

Consequences of the Evolution of the GABAA Receptor Gene Family (2005)
Journal Article
Darlison, M. G., Pahal, I., & Thode, C. (2005). Consequences of the Evolution of the GABAA Receptor Gene Family. Cellular and Molecular Neurobiology, 25(3-4), 607-624. https://doi.org/10.1007/s10571-005-4004-4

1. This paper reviews the evolution of the family of genes present in mammals and other vertebrates that encode $γ$-aminobutyric acid (GABA) type A (GABAA) receptors, which are the major inhibitory neurotransmitter receptors in the central nervous sy... Read More about Consequences of the Evolution of the GABAA Receptor Gene Family.

Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit (2005)
Journal Article
Jones, A. K. M., Marshall, A., Darlison, M., Blake, A., Buckingham, S., Darlison, M., & Sattelle, D. (2005). Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit. Invertebrate Neuroscience, 5(3-4), 147-155. https://doi.org/10.1007/s10158-005-0007-6

The cloning, sequencing and functional expression of Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor (nAChR) subunit is described. This subunit shows 80% identity with the Drosophila melanogaster Dβ1 and 92% identi... Read More about Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit.

Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain (1986)
Book Chapter
Squire, M. D., Moss, S. J., Lai, F. A., Darlison, M. G., Cockcroft, V. B., Barnard, E. A., Beeson, D. M. W., Hicks, A. A., Darlison, M. G., & Ross, S. J. (1986). Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain. In A. Maelicke (Ed.), Nicotinic Acetylcholine Receptor (389-415). Springer. https://doi.org/10.1007/978-3-642-71649-2_30

While it has been completely established that the AChR** as isolated from the electroplaques of electric fish is composed of four different polypeptides, such that its subunit structure is α2βγδ (as reviewed in detail elsewhere in this Volume), the e... Read More about Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain.

Self-reported sports injuries and later-life health status in 3357 retired Olympians from 131 countries: a cross-sectional survey among those competing in the games between London 1948 and PyeongChang 2018 (2020)
Journal Article
Palmer, D., Cooper, D. J., Emery, C., Batt, M. E., Engebretsen, L., Scammell, B. E., Schamasch, P., Shroff, M., Soligard, T., Steffen, K., Whittaker, J. L., & Budgett, R. (2020). Self-reported sports injuries and later-life health status in 3357 retired Olympians from 131 countries: a cross-sectional survey among those competing in the games between London 1948 and PyeongChang 2018. British Journal of Sports Medicine, 55(1), 46-53. https://doi.org/10.1136/bjsports-2019-101772

Objective: Describe the self-reported prevalence and nature of Olympic-career injury and general health and current residual symptoms in a self-selected sample of retired Olympians. Methods: 3357 retired Olympians from 131 countries completed a cr... Read More about Self-reported sports injuries and later-life health status in 3357 retired Olympians from 131 countries: a cross-sectional survey among those competing in the games between London 1948 and PyeongChang 2018.