Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3

Bailey, Mark E.S.; Albrecht, Barbara E.; Johnson, Keith J.; Darlison, Mark G.

Abstract

{GABAC} receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: ρ1 (GABRR1), ρ2 (GABRR2) and ρ3 (GABRR3). We show that {GABRR1} and {GABRR2} are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but that {GABRR3} maps to chromosome 3q11-q13.3. Our mapping data suggest that the ρ polypeptide genes, which are thought to share a common ancestor with {GABAA} receptor subunit genes, diverged at an early stage in the evolution of this gene family.

Citation

Bailey, M. E., Albrecht, B. E., Johnson, K. J., & Darlison, M. G. (1999). Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. BBA - Gene Structure and Expression, 1447(2-3), 307-312. https://doi.org/10.1016/s0167-4781%2899%2900167-0

• Journal Article Type: Article
• Acceptance Date: Aug 24, 1999
• Online Publication Date: Oct 25, 1999
• Publication Date: 1999-10
• Deposit Date: Jul 26, 2016
• Journal: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
• Print ISSN: 0167-4781
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 1447
• Issue: 2-3
• Pages: 307-312
• DOI: https://doi.org/10.1016/s0167-4781%2899%2900167-0
• Keywords: Biophysics; Genetics; Biochemistry; Structural Biology
• Public URL: http://researchrepository.napier.ac.uk/Output/316347