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ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2 (2008)
Journal Article
Stevens, C., Pettersson, S., Wawrzynow, B., Wallace, M., Ball, K., Zylicz, A., & Hupp, T. R. (2008). ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2. FEBS Journal, 275(19), 4875-4886. https://doi.org/10.1111/j.1742-4658.2008.06627.x

Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit... Read More about ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2.

Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence (2002)
Journal Article
Taylor, C. M., Beresford, M., Epton, H. A. S., Sigee, D. C., Shama, G., Andrew, P. W., & Roberts, I. S. (2002). Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence. Journal of Bacteriology, 184(3), 621-628. https://doi.org/10.1128/JB.184.3.621-628.2002

We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth after attachment to a model surface. Both mutants were unable to accumulate (p)... Read More about Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence.

Therapeutic potential of Tregs to treat rheumatoid arthritis (2011)
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there ar... Read More about Therapeutic potential of Tregs to treat rheumatoid arthritis.

The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men (2009)
Journal Article
Gray, S. R., Clifford, M., Lancaster, R., Leggate, M., Davies, M., & Nimmo, M. A. (2009). The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. Cytokine, 47(2), 98-102. https://doi.org/10.1016/j.cyto.2009.05.011

The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating l... Read More about The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men.

The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment (1990)
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1990). The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment. Acta tropica, 47(5-6), 323-330. https://doi.org/10.1016/0001-706x%2890%2990033-v

The biophysical properties of the surface lipid of a range of nematode species and their developmental stages were examined, using fluorescent lipid probes and fluorescence recovery after photobleaching (FRAP). These methods can be applied to living,... Read More about The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment.

Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells (2008)
Journal Article
Rae, M. T., Price, D., Harlow, C. R., Critchley, H. O. D., & Hillier, S. G. (2009). Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells. Fertility and Sterility, 92(2), 703-708. https://doi.org/10.1016/j.fertnstert.2008.06.040

Objective To obtain proof-of-concept that locally produced anti-inflammatory steroids suppress ovulation-associated extracellular matrix proteases in human ovarian surface epithelial (OSE) cells. Design Primary OSE cell cultures treated with int... Read More about Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells.

Metal cation uptake by yeast: a review (1995)
Journal Article
Blackwell, K. J., Singleton, I., & Tobin, J. M. (1995). Metal cation uptake by yeast: a review. Applied microbiology and biotechnology, 43(4), 579-584. https://doi.org/10.1007/s002530050454

This review addresses metal uptake specifically by yeast. Metal uptake may be passive, active or both, depending on the viability of the biomass, and is influenced by a number of environmental and experimental factors. Uptake is typically accompanied... Read More about Metal cation uptake by yeast: a review.

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease (2009)
Journal Article
Kerr, F., Augustin, H., Piper, M. D. W., Gandy, C., Allen, M. J., Lovestone, S., & Partridge, L. (2011). Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiology of Aging, 32(11), 1977-1989. https://doi.org/10.1016/j.neurobiolaging.2009.10.015

Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions,... Read More about Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease.

Examining Dementia Caregivers’ Experiences (2016)
Journal Article
Joy, J., Whitelaw, T., Oldfather, I., & Willis, D. (2016). Examining Dementia Caregivers’ Experiences. International Journal of Aging and Society, 7(2), 59-72. https://doi.org/10.18848/2160-1909/CGP/v07i02/59-72

There are 46.8 million people living with dementia in the world and this number is expected to rise (The World Alzheimer Report 2015). The burden on caregivers can be enormous, yet in the UK they save the NHS and Social care services millions of pou... Read More about Examining Dementia Caregivers’ Experiences.

Response of intertidal macrofauna to multiple disturbance types and intensities – An experimental approach (2009)
Journal Article
Whomersley, P., Huxham, M., Bolam, S., Schratzberger, M., Augley, J., & Ridland, D. (2010). Response of intertidal macrofauna to multiple disturbance types and intensities – An experimental approach. Marine Environmental Research, 69(5), 297-308. https://doi.org/10.1016/j.marenvres.2009.12.001

Two of the best-supported theories which describe the effects of disturbance within marine benthic habitats are the organic enrichment ‘Successional Model’ and the ‘Intermediate Disturbance Hypothesis’. Underlying these models, biological mechanisms... Read More about Response of intertidal macrofauna to multiple disturbance types and intensities – An experimental approach.

Was treating to national targets appropriate for all patients who participated in a secondary prevention program? (2012)
Journal Article
Neubeck, L., Lowres, N., Redfern, J., & Freedman, B. (2012). Was treating to national targets appropriate for all patients who participated in a secondary prevention program?. Heart, Lung and Circulation, 21(1), S316. https://doi.org/10.1016/j.hlc.2012.05.781

Abstract from the Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, 16-19 August 2012, Brisbane

Recent temporal changes in lipid management and serum cholesterol after acute coronary syndromes. (2011)
Journal Article
Neubeck, L., Redfern, J., Briffa, T., Bauman, A., & Freedman, S. (2011). Recent temporal changes in lipid management and serum cholesterol after acute coronary syndromes. Heart, Lung and Circulation, 20(2), S249. https://doi.org/10.1016/j.hlc.2011.05.611

Lipid lowering is of paramount importance in the prevention of recurrent cardiovascular events. Our original CHOICE (Choice of Health Options In prevention of Cardiovascular Events) trial demonstrated significant benefit in lowering total cholesterol... Read More about Recent temporal changes in lipid management and serum cholesterol after acute coronary syndromes..

Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report (2011)
Journal Article
Hutton, P., Morrison, A. P., & Taylor, H. (2012). Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report. Behavioural and Cognitive Psychotherapy, 40(1), 111-116

Background: Cognitive behavioural therapy (CBT) can be helpful for many people who experience psychosis; however most research trials have been conducted with people also taking antipsychotic medication. There is little evidence to know whether CBT... Read More about Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report.

Electronic prescribing and prescription design in ophthalmic practice (2011)
Journal Article
Connor, A. J., Hutton, P., Severn, P., & Masri, I. (2011). Electronic prescribing and prescription design in ophthalmic practice. European Journal of Ophthalmology, 21(5), 644-648. https://doi.org/10.5301/EJO.2011.6225

PURPOSE: Prescription and drug errors are common causes of adverse clinical events, posing a significant risk to safe patient care. Although there has been a movement to increase the use of electronic prescribing, concerns over feasibility suggest th... Read More about Electronic prescribing and prescription design in ophthalmic practice.