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Outputs (215)

Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit (2020)
Journal Article
Adams, C. E., & Dancer, S. J. (2020). Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit. International Journal of Environmental Research and Public Health, 17(6), Article 2109. https://doi.org/10.3390/ijerph17062109

Staphylococcus aureus is an important bacterial pathogen. This study utilized known staphylococcal epidemiology to track S. aureus between patients, surfaces, staff hands and air in a ten-bed intensive care unit (ICU). Methods: Patients, air and surf... Read More about Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit.

Can we do better? A guide to pandemics – some Dos and Don'ts for the next one (2021)
Journal Article
Tang, J. W., Kwok, K. O., Loh, T. P., Lee, C. K., Heraud, J., & Dancer, S. J. (2021). Can we do better? A guide to pandemics – some Dos and Don'ts for the next one. Journal of Infection, 83(1), 119-145. https://doi.org/10.1016/j.jinf.2021.04.017

Specific features of any rapidly spread pathogen needs early recognition and assessment for possible pandemic potential. These include: inter-person transmissibility and exponential spread, which results in significant morbidity, mortality. These a... Read More about Can we do better? A guide to pandemics – some Dos and Don'ts for the next one.

How dirty is your QWERTY? The risk of healthcare pathogen transmission from computer keyboards (2021)
Journal Article
Ledwoch, K., Dancer, S., Otter, J., Kerr, K., Roposte, D., & Maillard, J. (2021). How dirty is your QWERTY? The risk of healthcare pathogen transmission from computer keyboards. Journal of Hospital Infection, 112, 31-36. https://doi.org/10.1016/j.jhin.2021.02.021

Introduction Healthcare environmental surfaces may be contaminated with micro-organisms that cause healthcare-associated infections (HCAIs). Special attention is paid to near-patient surfaces but sites outside the patient zone receive less attention... Read More about How dirty is your QWERTY? The risk of healthcare pathogen transmission from computer keyboards.

A paradigm shift to combat indoor respiratory infection (2021)
Journal Article
Morawska, L., Allen, J., Bahnfleth, W., Bluyssen, P. M., Boerstra, A., Buonanno, G., …Yao, M. (2021). A paradigm shift to combat indoor respiratory infection. Science, 372(6543), 689-691. https://doi.org/10.1126/science.abg2025

There is great disparity in the way we think about and address different sources of environmental infection. Governments have for decades promulgated a large amount of legislation and invested heavily in food safety, sanitation, and drinking water fo... Read More about A paradigm shift to combat indoor respiratory infection.

Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion (2021)
Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., Wilson, K., Chianini, F., Silvia Rocchi, M., Wheelhouse, N., Entrican, G., & Longbottom, D. (2021). Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), Article 898. https://doi.org/10.3390/vaccines9080898

Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of... Read More about Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion.

Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer (2022)
Presentation / Conference Contribution
Bruce, I., Pang, L., Poole, A., & Fraser, J. (2022, November). Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer. Poster presented at Society for Endocrinology BES 2022, Harrogate

Neuroendocrine castrate resistant prostate cancer (NE-CRPC) is a lethal CRPC subtype that arises as prostate cancer cells transdifferentiate to neuroendocrine cells, evading the potent selective pressure of androgen deprivation therapies (ADT). Curre... Read More about Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer.

Meaningfully Embedding Industry-Relevant Life Science Skills in the Undergraduate Biosciences Curriculum (2023)
Presentation / Conference Contribution
Garden, C., Campbell Casey, S., & MacCallum, J. (2023, June). Meaningfully Embedding Industry-Relevant Life Science Skills in the Undergraduate Biosciences Curriculum. Presented at QAA Scotland's 5th International Enhancement Conference, Glasgow

For more than a decade I and colleagues have been working in partnership with the Scottish Lifesciences industry and other stakeholders to develop relevant, industry informed biosciences curricula at Edinburgh Napier University. This work has also be... Read More about Meaningfully Embedding Industry-Relevant Life Science Skills in the Undergraduate Biosciences Curriculum.

Chk2 activates E2F-1 in response to DNA damage (2003)
Journal Article
Stevens, C., Smith, L., & La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409. https://doi.org/10.1038/ncb974

The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. A Chk2 c... Read More about Chk2 activates E2F-1 in response to DNA damage.

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2 (2008)
Journal Article
Stevens, C., Pettersson, S., Wawrzynow, B., Wallace, M., Ball, K., Zylicz, A., & Hupp, T. R. (2008). ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2. FEBS Journal, 275(19), 4875-4886. https://doi.org/10.1111/j.1742-4658.2008.06627.x

Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit... Read More about ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2.

Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. (2003)
Journal Article
Dancer, S. J., Robb, A., Crawford, A., & Morrison, D. (2003). Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Antimicrobial Chemotherapy, 51, 731-735. https://doi.org/10.1093/jac/dkg143

Objectives: Chronic methicillin-resistant Staphylococcus aureus (MRSA) infections in debilitated patients are difficult to treat. We studied the clinical efficacy and safety of an oral streptogramin, pristinamycin, for these patients. Patients an... Read More about Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections..

Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence (2002)
Journal Article
Taylor, C. M., Beresford, M., Epton, H. A. S., Sigee, D. C., Shama, G., Andrew, P. W., & Roberts, I. S. (2002). Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence. Journal of Bacteriology, 184(3), 621-628. https://doi.org/10.1128/JB.184.3.621-628.2002

We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth after attachment to a model surface. Both mutants were unable to accumulate (p)... Read More about Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence.

The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment (1990)
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1990). The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment. Acta tropica, 47(5-6), 323-330. https://doi.org/10.1016/0001-706x%2890%2990033-v

The biophysical properties of the surface lipid of a range of nematode species and their developmental stages were examined, using fluorescent lipid probes and fluorescence recovery after photobleaching (FRAP). These methods can be applied to living,... Read More about The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment.

Pentachlorophenol transformation in soil: a toxicological assessment (2000)
Journal Article
McGrath, R., & Singleton, I. (2000). Pentachlorophenol transformation in soil: a toxicological assessment. Soil Biology and Biochemistry, 32(8-9), 1311-1314. https://doi.org/10.1016/s0038-0717%2800%2900015-8

Bioremediation is recognised as an economically viable method to treat contaminated soil and the use of microbial inoculants, in particular, white-rot fungi, has been proposed to enhance the remediation process. During bioremediation, a variety of po... Read More about Pentachlorophenol transformation in soil: a toxicological assessment.