Dr Giacomo Russo G.Russo@napier.ac.uk
Lecturer
A Permeapad sample preparation workflow for the selective determination of anticonvulsants in human serum and urines by GC MS/MS.
People Involved
Amy Dillon A.Dillon@napier.ac.uk
Skills Enhancement Tutor
Project Description
The study will employ a Permeapad 96-well plate system, which mimics passive diffusion barriers found in the human body. Commercially available bovine serum and urine samples will be spiked with specific concentrations of the target anticonvulsants. The workflow will include enzymatic hydrolysis, Permeapad extraction, and GC-MS/MS analysis with a butylation derivatization. Experimental variables, including pH and solvent concentration, will be optimized. The method's performance will be validated through recovery studies and comparison with conventional techniques, such as SPE.
| Type of Project | P04 - Research Charities and Trusts |
|---|---|
| Status | Project Live |
| Funder(s) | Analytical Chemistry Trust Fund |
| Value | £3,520.00 |
| Project Dates | Jul 1, 2025 - Aug 31, 2025 |
| This project contributes to the following UN Sustainable Development Goals |
|
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