Research Repository
MRes
Master's Degree
Level Master's Degree Student Aziz Kiran Status Complete Part Time No Years 2021 - 2023 Project Title Design, synthesis and evaluation of hybrid intracellularly targeted anticancer and antimicrobial agents Awarding Institution Edinburgh Napier University Second Supervisor Agnes Turnbull Additional Supervisor Janis MacCallum
MRes
Master's Degree
Level Master's Degree Student Judith Ajaezu Status Complete Part Time No Years 2021 - 2023 Project Title Design of a new fluorogenic molecular probe of lipases that will be specific for monoacylglycerol lipase Awarding Institution Edinburgh Napier University Second Supervisor Agnes Turnbull Additional Supervisor Janis MacCallum
PhD
Doctorate
Level Doctorate Student Mohamad Kamel Status Complete Part Time No Years 2018 - 2023 Project Title Design, synthesis and cytotoxicity of bifunctional anticancer agents targeted to mitochondria Awarding Institution Edinburgh Napier University Second Supervisor Agnes Turnbull Additional Supervisor Janis MacCallum
MRes
Master's Degree
Level Master's Degree Student Deepthi Ravula Status Complete Part Time No Years 2018 - 2022 Project Title Synthesis and flourescence properties of a novel legumain substrate probe Awarding Institution Edinburgh Napier University Second Supervisor Agnes Turnbull
PhD
Doctorate
Level Doctorate Student Omar Mohammed Status Complete Part Time Yes Years 2014 - 2021 Project Title Design, synthesis and evaluation of novel and clinically used anti-cancer agents targeted intracellularly Project Description The majority of clinically used anticancer drugs suffer from poor selectivity for tumour cells over normal healthy cells, leading to poor efficacy and often severe dose-limiting side effects for patients. Chemotherapeutic drugs have a low therapeutic index due to exerting their anticancer effects at or near toxic doses and the development of drug resistance. In this project, new chemical approaches are being developed to improve the therapeutic index and concomitantly reduce significantly the side effects for the patient population.
A series of novel anticancer drugs is being synthesised, characterised and investigated for their selective tumour targeting ability and circumvention of major mechanisms of drug resistance. The novel strategy is exploiting subtle differences between the function of intracellular compartments in cancer cells compared to healthy cells; notably, mitochondria and lysosomes. The clinically used anticancer drug mitoxantrone and structurally related novel aminoanthraquinone derivatives are being linked with specific carriers including triphenylphosphonium bromide (TPP), to transport the drugs through the mitochondrial membrane of cancer cells, visualised by confocal microscopy. Selective accumulation causes tumour cell destruction whilst sparing healthy cells.Awarding Institution Edinburgh Napier University Second Supervisor Agnes Turnbull
About Edinburgh Napier Research Repository
Administrator e-mail: repository@napier.ac.uk
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Apache License Version 2.0 (http://www.apache.org/licenses/)
Apache License Version 2.0 (http://www.apache.org/licenses/)
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
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